INT77309

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.72
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr2c) plasma membrane (Htr2c) nucleus (Htr2c)
cytoplasm (Htr2c) signal transducer activity (Htr2c)
Htr2c (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 13 99.86 Very High Very High Very High
sSRI 14 95.68 Very High Very High Very High
Serotonin 36 95.48 Very High Very High Very High
depression 7 95.20 Very High Very High Very High
agonist 5 72.08 Quite High
Central nervous system 4 70.88 Quite High
Glutamate 20 51.60 Quite High
adenocard 22 5.00 Very Low Very Low Very Low
ischemia 10 5.00 Very Low Very Low Very Low
Action potential 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mental Disorders 4 98.84 Very High Very High Very High
Appetite Loss 11 95.32 Very High Very High Very High
Depression 7 95.20 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 91.56 High High
Stress 4 87.64 High High
Schizophrenia 10 84.96 Quite High
Premature Ejaculation 2 83.48 Quite High
Sprains And Strains 6 80.80 Quite High
Suicidal Behaviour 2 73.36 Quite High
Disease 8 72.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It appeared that the discriminatory stimulus of fluvoxamine is primarily mediated via 5-hydroxytryptamine (HT)1A receptors, whilst that of fluoxetine is primarily mediated via 5-HT2C receptors.
Positive_regulation (mediated) of 5-HT2C associated with fluoxetine
1) Confidence 0.49 Published 1998 Journal Int Clin Psychopharmacol Section Abstract Doc Link 9728669 Disease Relevance 0.45 Pain Relevance 0.76
We conclude that 5-HT1A receptors are involved in the stimulus properties of both fluvoxamine and fluoxetine, that 5-HT2C receptors are involved in fluvoxamine and especially fluoxetine, and, based primarily on the cross-comparison tests, that the two SSRIs have somewhat different stimulus properties.
Positive_regulation (involved) of 5-HT2C associated with ssri and fluoxetine
2) Confidence 0.49 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9888626 Disease Relevance 0.60 Pain Relevance 0.87
Interestingly, two separate studies by Niswender et al, and Iwamoto and Kato report increased RNA editing efficacy at the A-site of 5-HT2CR mRNA in depressed patients.
Positive_regulation (increased) of 5-HT2CR
3) Confidence 0.49 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.64 Pain Relevance 0.22
A-to-I editing of 5-HT2CR mRNA mediated by ADARs may be involved in mental disorders, and the increased understanding of the editing mechanism and target spectrum can explain some of the phenotypic features that result from RNA editing deficiency or hyperactivity.
Positive_regulation (mediated) of 5-HT2CR associated with mental disorders and attention deficit hyperactivity disorder
4) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 1.02 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox