INT77310

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 89
Total Number 94
Disease Relevance 50.49
Pain Relevance 33.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) cytoplasm (Aif1)
Anatomy Link Frequency
macrophages 15
microglia 15
monocyte 6
CNS 3
striatum 2
Aif1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 696 100.00 Very High Very High Very High
cytokine 257 100.00 Very High Very High Very High
Neuritis 97 100.00 Very High Very High Very High
ischemia 732 99.96 Very High Very High Very High
Peripheral nervous system 51 99.88 Very High Very High Very High
dexamethasone 70 99.72 Very High Very High Very High
Central nervous system 281 99.68 Very High Very High Very High
Cannabinoid receptor 66 99.64 Very High Very High Very High
allodynia 206 99.36 Very High Very High Very High
Spinal cord 340 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 810 100.00 Very High Very High Very High
Multiple Sclerosis 70 100.00 Very High Very High Very High
Uveitis 64 100.00 Very High Very High Very High
Neuritis 40 100.00 Very High Very High Very High
Cv Unclassified Under Development 588 99.96 Very High Very High Very High
Hypersensitivity 252 99.74 Very High Very High Very High
Disease 396 99.72 Very High Very High Very High
Neuropathic Pain 467 99.36 Very High Very High Very High
Autoimmune Disease 20 98.48 Very High Very High Very High
Demyelinating Disease 20 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then investigated expression of AIF-1 in experimental autoimmune encephalomyelitis (EAE), neuritis (EAN), and uveitis (EAU).
Spec (investigated) Gene_expression (expression) of AIF-1 associated with multiple sclerosis, uveitis and neuritis
1) Confidence 0.78 Published 1998 Journal Glia Section Abstract Doc Link 9728770 Disease Relevance 0.87 Pain Relevance 0.30
Allograft-inflammatory factor-1 in rat experimental autoimmune encephalomyelitis, neuritis, and uveitis: expression by activated macrophages and microglial cells.
Gene_expression (expression) of Allograft-inflammatory factor-1 in microglial cells associated with multiple sclerosis, inflammation, uveitis, neuritis and cytokine
2) Confidence 0.78 Published 1998 Journal Glia Section Title Doc Link 9728770 Disease Relevance 0.88 Pain Relevance 0.36
In order to investigate the role of AIF-1 in autoimmune lesions of the rat nervous system, we have used a synthetic gene to express AIF-1 in E. coli and have produced monoclonal antibodies against AIF-1.
Gene_expression (express) of AIF-1 in nervous system
3) Confidence 0.78 Published 1998 Journal Glia Section Abstract Doc Link 9728770 Disease Relevance 0.77 Pain Relevance 0.27
Allograft inflammatory factor-1 (AIF-1) is a Ca2+ binding peptide expressed predominantly by activated monocytes.
Gene_expression (expressed) of AIF-1 in monocytes associated with inflammation
4) Confidence 0.78 Published 1998 Journal Glia Section Abstract Doc Link 9728770 Disease Relevance 0.71 Pain Relevance 0.25
In accordance with prevention of neurological signs, histological observations revealed that accumulation of activated monocytes expressing EMAP II and AIF-1 in the CNS or peripheral nervous system and the massive expression of these factors by parenchymal microglial cells is inhibited by high doses of autoantigen.
Gene_expression (expressing) of AIF-1 in microglial cells associated with peripheral nervous system and central nervous system
5) Confidence 0.77 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 1.23 Pain Relevance 0.67
Thus, expression of EMAP II and AIF-1 by infiltrating activated macrophages is a marker of disease activity and expression of these factors could be used to demonstrate 'silent' lesions in the CNS and prolonged microglial cell activation.
Gene_expression (expression) of AIF-1 in CNS associated with central nervous system and disease
6) Confidence 0.77 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 0.92 Pain Relevance 0.55
In these cases, a smoldering expression of EMAP II and AIF-1 persisting long after cessation of neurological signs was observed.
Gene_expression (expression) of AIF-1
7) Confidence 0.77 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 1.02 Pain Relevance 0.61
In particular, parenchymal microglial cells were now activated to express AIF-1 and EMAP II.
Gene_expression (express) of AIF-1 in microglial cells
8) Confidence 0.77 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 1.27 Pain Relevance 0.68
Only rather limited expression of EMAP II and AIF-1 is seen in the normal central nervous system (CNS).
Gene_expression (expression) of AIF-1 in CNS associated with central nervous system
9) Confidence 0.77 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 1.29 Pain Relevance 0.66
Dexamethasone prevented or abolished local expression of EMAP II and AIF-1 at days 10-16.
Gene_expression (expression) of AIF-1 associated with dexamethasone
10) Confidence 0.77 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 1.08 Pain Relevance 0.66
Regarding glial reactivity, we found an early microglial response, with the highest increase of isolectin B4 (IB4) and Iba1 expression at 3 days, and a slower and progressive response of astrocytes, shown by increasing expression of glial fibrillary acidic protein (GFAP) during the 28 days studied.
Gene_expression (expression) of Iba1 in IB4
11) Confidence 0.75 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19331524 Disease Relevance 0 Pain Relevance 0
However, it has been reported that AIF-1 is also expressed in macrophages and microglial cells in autoimmune diseases such as experimental autoimmune encephalomyelitis, neuritis and uveitis models, suggesting that AIF-1 may play a pivotal role in autoimmunity.
Gene_expression (expressed) of AIF-1 in microglial cells associated with multiple sclerosis, autoimmune disease, uveitis and neuritis
12) Confidence 0.70 Published 2007 Journal Autoimmunity Section Abstract Doc Link 17453710 Disease Relevance 0.72 Pain Relevance 0.26
The expression of AIF-1 was mostly limited to the monocyte/macrophage lineage, and augmented by cytokines such as IFN-gamma.
Gene_expression (expression) of AIF-1 in macrophage associated with cytokine
13) Confidence 0.70 Published 2007 Journal Autoimmunity Section Abstract Doc Link 17453710 Disease Relevance 0.58 Pain Relevance 0.24
The levels of the microglial markers OX-42 and IBA-1 and of the astrocytic marker GFAP were analysed using immunohistochemistry and Western blots.
Spec (analysed) Gene_expression (levels) of IBA-1
14) Confidence 0.68 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17158026 Disease Relevance 0.79 Pain Relevance 0.55
In accordance with prevention of neurological signs, histological observations revealed that accumulation of activated monocytes expressing EMAP II and AIF-1 in the CNS or peripheral nervous system and the massive expression of these factors by parenchymal microglial cells is inhibited by high doses of autoantigen.
Gene_expression (expressing) of AIF-1 in microglial cells associated with peripheral nervous system and central nervous system
15) Confidence 0.67 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 1.23 Pain Relevance 0.67
Thus, expression of EMAP II and AIF-1 by infiltrating activated macrophages is a marker of disease activity and expression of these factors could be used to demonstrate 'silent' lesions in the CNS and prolonged microglial cell activation.
Gene_expression (expression) of AIF-1 in CNS associated with central nervous system and disease
16) Confidence 0.67 Published 1999 Journal Acta Neuropathol. Section Abstract Doc Link 9928822 Disease Relevance 0.92 Pain Relevance 0.55
Effects of autoantigen and dexamethasone treatment on expression of endothelial-monocyte activating polypeptide II and allograft-inflammatory factor-1 by activated macrophages and microglial cells in lesions of experimental autoimmune encephalomyelitis, neuritis and uveitis.
Gene_expression (expression) of allograft-inflammatory factor-1 in microglial cells associated with multiple sclerosis, inflammation, uveitis, neuritis, dexamethasone and cytokine
17) Confidence 0.67 Published 1999 Journal Acta Neuropathol. Section Title Doc Link 9928822 Disease Relevance 1.19 Pain Relevance 0.58
Augmented expression of daintain/allograft inflammatory factor-1 is associated with clinical disease: dynamics of daintain/allograft inflammatory factor-1 expression in spleen, peripheral nerves and sera during experimental autoimmune neuritis.
Gene_expression (expression) of daintain/allograft inflammatory factor-1 in spleen associated with inflammation, experimental autoimmune neuritis, disease and neuritis
18) Confidence 0.65 Published 2000 Journal Scand. J. Immunol. Section Title Doc Link 10931378 Disease Relevance 1.46 Pain Relevance 1.04
Augmented expression of daintain/allograft inflammatory factor-1 is associated with clinical disease: dynamics of daintain/allograft inflammatory factor-1 expression in spleen, peripheral nerves and sera during experimental autoimmune neuritis.
Gene_expression (expression) of daintain/allograft inflammatory factor-1 in spleen associated with inflammation, experimental autoimmune neuritis, disease and neuritis
19) Confidence 0.65 Published 2000 Journal Scand. J. Immunol. Section Title Doc Link 10931378 Disease Relevance 1.40 Pain Relevance 0.94
Daintain/allograft inflammatory factor-1 (daintain/AIF-1) is a novel interferon-gamma-inducible protein expressed by macrophages during organ specific autoimmune diseases.
Gene_expression (expressed) of Daintain/allograft inflammatory factor-1 in macrophages associated with autoimmune disease and inflammation
20) Confidence 0.64 Published 2000 Journal Scand. J. Immunol. Section Abstract Doc Link 10931378 Disease Relevance 1.40 Pain Relevance 0.97

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