INT77311

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.21
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) cytoplasm (Aif1)
Anatomy Link Frequency
microglia 5
macrophages 1
lymphoid tissue 1
oligodendroglia 1
Aif1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 99.16 Very High Very High Very High
conotoxin 2 94.96 High High
Spinal cord 74 92.64 High High
Dorsal horn 22 91.88 High High
antagonist 45 91.16 High High
Trigeminal ganglion neurons 30 90.64 High High
Inflammation 65 90.16 High High
Neuritis 2 83.36 Quite High
B1 receptor 97 81.16 Quite High
allodynia 64 79.28 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 69 97.80 Very High Very High Very High
Infection 66 95.64 Very High Very High Very High
Disease 46 94.92 High High
Nervous System Injury 100 94.40 High High
INFLAMMATION 76 90.16 High High
Multiple Sclerosis 3 87.28 High High
Hyperglycemia 8 85.76 High High
Neuritis 2 83.36 Quite High
Uveitis 2 81.76 Quite High
Ocular Hypertension 188 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIF-1 was localized to monocytes/macrophages with rather selective staining of a minor rat monocyte subpopulation of lymphoid tissue.
Localization (localized) of AIF-1 in lymphoid tissue
1) Confidence 0.75 Published 1998 Journal Glia Section Abstract Doc Link 9728770 Disease Relevance 0.80 Pain Relevance 0.28
Our data show that concomitantly with the up-regulation of the microglia associated transcripts (CD68 and AIF-1), the released "On" signals matrix-metalloproteinase-3 (MMP-3) and CXCL10 are up-regulated in the acute phase (1 day after infection) of the disease, whereas the released "Off" signal CX3CL1 is down-regulated.
Localization (released) of AIF-1 in microglia associated with metalloproteinase, disease and infection
2) Confidence 0.39 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.46 Pain Relevance 0.12
Effect of microglia inhibitors on Iba-1 microglial immunoreactivity
Localization (immunoreactivity) of Iba-1 in microglia
3) Confidence 0.38 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.45 Pain Relevance 0.38
Remarkably, almost all BrdU positive cells were colocalized with Iba1, a microglial marker (Fig. 3B-D).
Localization (colocalized) of Iba1
4) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.34 Pain Relevance 0.45
Microglia were stained with a rabbit polyclonal antibody directed against Iba-1 (1?
Localization (directed) of Iba-1 in Microglia
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.09
The iba-1 protein is specifically localized in microglia and is not found in neurons, astrocytes, or oligodendroglia [31, 32].
Localization (localized) of iba-1 protein in oligodendroglia
6) Confidence 0.24 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 0.28 Pain Relevance 0
In LBP-fed rats, the microglia displayed increased iba-1 immunoreactivity in both the soma and processes.
Localization (immunoreactivity) of iba-1 in microglia
7) Confidence 0.19 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 0.47 Pain Relevance 0
M) were used to examine possible contribution of each Ca2+ channel to the zolmitriptan-sensitive IBa, respectively.
Spec (possible) Localization (contribution) of IBa
8) Confidence 0.14 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0.06 Pain Relevance 0.12
Three different labels were used for microglia and macrophages: an antibody against rat CD11b/c, which is also called complement receptor 3 (OX-42; mouse monoclonal, AbD Serotec, Oxford, UK), an antibody against 'ionized calcium-binding adapter-1' (Iba-1; rabbit polyclonal, Wako, Osaka, Japan), or tomato lectin (as above).
Localization (called) of Iba-1 in macrophages
9) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.18 Pain Relevance 0.03
And peak currents of IBa were significantly decreased to 81±5.3, 56±13, 41±5.4, 6±0.6, and 2±2% of the control at 1, 5, 10, 20, and 30 mM putrescine, respectively (n=9, 5, 5, 5, and 5, respectively; p<0.05; IC50=8 mM; Fig. 6E).


Localization (decreased) of IBa
10) Confidence 0.05 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693568 Disease Relevance 0 Pain Relevance 0
Three different labels were used for microglia and macrophages: an antibody against rat CD11b/c, which is also called complement receptor 3 (OX-42; mouse monoclonal, AbD Serotec, Oxford, UK), an antibody against 'ionized calcium-binding adapter-1' (Iba-1; rabbit polyclonal, Wako, Osaka, Japan), or tomato lectin (as above).
Localization (called) of Iba-1 in microglia
11) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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