INT77314

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Context Info
Confidence 0.76
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 11
Disease Relevance 5.67
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Lxn)
Anatomy Link Frequency
chondrocytes 3
neurons 2
cartilage 1
osteoblast 1
lung 1
Lxn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 2 99.86 Very High Very High Very High
substance P 2 99.44 Very High Very High Very High
Calcitonin gene-related peptide 2 99.04 Very High Very High Very High
Inflammation 18 98.78 Very High Very High Very High
dorsal root ganglion 8 97.86 Very High Very High Very High
Pain 9 96.76 Very High Very High Very High
qutenza 4 89.12 High High
Spinal cord 2 81.92 Quite High
Osteoarthritis 99 80.24 Quite High
Sciatic nerve 2 77.60 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 216 99.40 Very High Very High Very High
Pancreatitis 9 99.24 Very High Very High Very High
Osteoporosis 27 99.20 Very High Very High Very High
INFLAMMATION 18 98.78 Very High Very High Very High
Ganglion Cysts 8 97.86 Very High Very High Very High
Nociception 11 97.80 Very High Very High Very High
Pulmonary Disease 9 97.80 Very High Very High Very High
Bone Fracture 9 96.92 Very High Very High Very High
Pain 9 96.76 Very High Very High Very High
Aging 27 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, LXN expression in the nucleus and cytoplasm of proliferating and prehypertrophic chondrocytes in the embryonic tibiae and callus during skeletogenesis and skeletal regeneration was described [9].
Gene_expression (expression) of LXN in chondrocytes
1) Confidence 0.76 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2904732 Disease Relevance 0.41 Pain Relevance 0
Immunohistochemical detection of LXN
Gene_expression (detection) of LXN
2) Confidence 0.76 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2904732 Disease Relevance 0.94 Pain Relevance 0.18
It has recently been reported that LXN is expressed in proliferating and prehypertrophic chondrocytes during skeletogenesis and bone fracture repair [9].
Gene_expression (expressed) of LXN in chondrocytes associated with bone fracture
3) Confidence 0.76 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2904732 Disease Relevance 0.31 Pain Relevance 0
Also, it has been suggested that LXN is involved in pain perception according to the location on nociceptive neurons in sensory ganglia [22], in inflammation for its expression on stimulated mouse macrophages [23] and LXN gene expression was identified in acute pancreatitis and inflammatory lung diseases [24].
Gene_expression (expression) of LXN gene in lung associated with nociception, pain, pulmonary disease, inflammation and pancreatitis
4) Confidence 0.76 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2904732 Disease Relevance 0.90 Pain Relevance 0.22
Most of the dorsal root ganglion (DRG) neurons containing either calcitonin gene-related peptide (CGRP), substance P (SP) or somatostatin (SST) coexpressed latexin.
Gene_expression (coexpressed) of latexin in neurons associated with ganglion cysts, dorsal root ganglion, somatostatin, substance p and calcitonin gene-related peptide
5) Confidence 0.75 Published 1998 Journal Brain Res. Section Abstract Doc Link 9729242 Disease Relevance 0.36 Pain Relevance 0.55
Most of the smaller diameter neurons of dorsal root and trigeminal ganglia in adult rats expressed latexin, which has the inhibitor activity of carboxypeptidase A.
Gene_expression (expressed) of latexin in neurons
6) Confidence 0.75 Published 1998 Journal Brain Res. Section Abstract Doc Link 9729242 Disease Relevance 0.31 Pain Relevance 0.42
It was also reported that bone morphogenetic protein-2 (BMP-2) signaling pathway regulates LXN expression during chondrocyte/osteoblast differentiation [9].
Gene_expression (expression) of LXN in osteoblast associated with osteoporosis
7) Confidence 0.67 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2904732 Disease Relevance 0.42 Pain Relevance 0
Further studies will be important to determine if there are statistically significant differences in expression levels of LXN in normal and osteoarthritic cartilage.
Gene_expression (expression) of LXN in cartilage associated with osteoarthritis
8) Confidence 0.67 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2904732 Disease Relevance 0.67 Pain Relevance 0.06
Interestingly, latexin (LXN) was found.
Gene_expression (found) of LXN
9) Confidence 0.59 Published 2010 Journal Proteome Sci Section Abstract Doc Link PMC2904732 Disease Relevance 0.50 Pain Relevance 0.12
To date, LXN expression and localization in mature bone has not yet been determined.
Gene_expression (expression) of LXN
10) Confidence 0.52 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2904732 Disease Relevance 0.43 Pain Relevance 0
It was also reported that bone morphogenetic protein-2 (BMP-2) signaling pathway regulates LXN expression during chondrocyte/osteoblast differentiation [9].
Gene_expression (expression) of LXN in chondrocyte associated with osteoporosis
11) Confidence 0.23 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2904732 Disease Relevance 0.42 Pain Relevance 0

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