INT77324

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.45
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) plasma membrane (Npy1r) molecular_function (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
blood vessels 2
dentate gyrus 2
Npy1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 1 99.92 Very High Very High Very High
Anterior cingulate 1 98.12 Very High Very High Very High
Nucleus accumbens 2 96.60 Very High Very High Very High
depression 4 85.04 High High
antidepressant 2 83.36 Quite High
fluoxetine 5 81.76 Quite High
Serotonin 1 80.64 Quite High
Neuropeptide 4 78.32 Quite High
Codeine 109 59.84 Quite High
Morphine 16 58.88 Quite High
Disease Link Frequency Relevance Heat
Depression 4 85.04 High High
Sprains And Strains 5 77.04 Quite High
Pulpitis 1 63.88 Quite High
INFLAMMATION 2 50.00 Quite Low
Depressive Disorder 1 25.00 Low Low
Pain 1 5.00 Very Low Very Low Very Low
Cough 1 5.00 Very Low Very Low Very Low
Diarrhoea 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Mental Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As pulpitis progressed, there was a significant decrease in number of blood vessels expressing Y1R in the odontoblast layer when compared to control rat pulp.
Negative_regulation (decrease) of Gene_expression (expressing) of Y1R in blood vessels
1) Confidence 0.42 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.06 Pain Relevance 0
Y1 receptor mRNA expression was decreased in different cortical regions (retrosplenial, anterior cingulate, and occipital) and in the hippocampal dentate gyrus.
Negative_regulation (decreased) of Gene_expression (expression) of Y1 in dentate gyrus associated with anterior cingulate
2) Confidence 0.32 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.38 Pain Relevance 0.67
Radiolabeled FC5 and FC45 RNA were prepared using the Ampliscribe T7 High Yield Transcription Kit with minor modifications to the manufacturer's instructions (3 mM each rATP, rCTP, rUTP, 150 ?
Negative_regulation (using) of Gene_expression (prepared) of FC5
3) Confidence 0.13 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.17

General Comments

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