INT77325

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2007
Negated 1
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 1.62
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) plasma membrane (Npy1r) molecular_function (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
neurons 3
arcuate nucleus 2
brains 2
spinal cord 1
Npy1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 10 100.00 Very High Very High Very High
Neuropeptide 7 100.00 Very High Very High Very High
Sciatic nerve 4 100.00 Very High Very High Very High
Spinal cord 2 99.20 Very High Very High Very High
depression 7 98.60 Very High Very High Very High
Dynorphin 1 98.08 Very High Very High Very High
fluoxetine 6 96.80 Very High Very High Very High
allodynia 4 87.12 High High
chung model 2 85.12 High High
Dorsal horn 2 77.48 Quite High
Disease Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
Depression 7 98.60 Very High Very High Very High
Neuropathic Pain 4 87.12 High High
Injury 4 73.76 Quite High
Nervous System Injury 2 68.84 Quite High
Sprains And Strains 5 59.00 Quite High
Depressive Disorder 1 32.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of a graded single constriction of the rat sciatic nerve on pain behavior and expression of immunoreactive NPY and NPY Y1 receptor in DRG neurons and spinal cord.
Regulation (Effect) of Gene_expression (expression) of Y1 receptor in neurons associated with pain, sciatic nerve and spinal cord
1) Confidence 0.41 Published 2004 Journal Brain Res. Section Title Doc Link 15047027 Disease Relevance 0.50 Pain Relevance 0.77
Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment.
Regulation (Alterations) of Gene_expression (expression) of Y1 in brains associated with depression, neuropeptide and fluoxetine
2) Confidence 0.34 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9729278 Disease Relevance 0.39 Pain Relevance 0.59
Conversely, as expected, arcuate nucleus NPY mRNA expression was markedly upregulated by negative energy balance, but was unchanged by recent food consumption.
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of NPY mRNA in arcuate nucleus
3) Confidence 0.21 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16931647 Disease Relevance 0 Pain Relevance 0.45
Effect of a graded single constriction of the rat sciatic nerve on pain behavior and expression of immunoreactive NPY and NPY Y1 receptor in DRG neurons and spinal cord.
Regulation (Effect) of in spinal cord Gene_expression (expression) of Y1 receptor in neurons associated with pain, sciatic nerve and spinal cord
4) Confidence 0.14 Published 2004 Journal Brain Res. Section Title Doc Link 15047027 Disease Relevance 0.50 Pain Relevance 0.77
Previously, we observed specific alterations of neuropeptide Y (NPY) and Y1 receptor mRNA expression in discrete regions of the Flinders Sensitive Line rats (FSL), an animal model of depression.
Regulation (alterations) of Gene_expression (expression) of Y1 receptor mRNA associated with depression and neuropeptide
5) Confidence 0.08 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10327163 Disease Relevance 0.22 Pain Relevance 0.30

General Comments

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