INT77333

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Context Info
Confidence 0.32
First Reported 1998
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.39
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hbegf) extracellular region (Hbegf) plasma membrane (Hbegf)
Anatomy Link Frequency
fibroblast 1
Hbegf (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 11 99.28 Very High Very High Very High
Opioid 6 99.20 Very High Very High Very High
lidocaine 14 98.64 Very High Very High Very High
Morphine 4 93.44 High High
Enkephalin 1 92.64 High High
agonist 2 91.52 High High
opiate 2 86.08 High High
Endogenous opioid 1 85.64 High High
Intracerebroventricular 6 82.32 Quite High
Angina 1 81.76 Quite High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 33 99.24 Very High Very High Very High
Cancer 6 98.96 Very High Very High Very High
Heart Disease 1 93.96 High High
Stroke 18 93.92 High High
Cv General 3 Under Development 3 81.76 Quite High
Depression 1 79.92 Quite High
Death 7 74.16 Quite High
INFLAMMATION 1 73.44 Quite High
Cv Unclassified Under Development 14 72.56 Quite High
Injury 6 66.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF) from the cell surface plays an important role in invasion by HT1080 cells.
heparin-binding epidermal growth factor-like growth factor Binding (heparin-binding) of
1) Confidence 0.32 Published 2002 Journal J. Cell. Physiol. Section Abstract Doc Link 12124780 Disease Relevance 0.29 Pain Relevance 0.49
Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF).
heparin-binding epidermal growth factor-like growth factor Binding (heparin-binding) of associated with cancer and lidocaine
2) Confidence 0.32 Published 2002 Journal J. Cell. Physiol. Section Title Doc Link 12124780 Disease Relevance 0.31 Pain Relevance 0.56
We investigated whether a decreased DTS is associated with increased mortality in a prospective cohort of 5,636 asymptomatic women.
DTS Binding (associated) of
3) Confidence 0.30 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 16054460 Disease Relevance 0.50 Pain Relevance 0.12
One recent study has demonstrated that intranasal fibroblast growth factor-2 (FGF-2) or heparin-binding epidermal growth factor-like growth factor (HB-EGF) increase neurogenesis in the normal adult mouse brain [7], but the effect of intranasal neurotrophic factors on neurogenesis in animals after stroke has not been investigated.
epidermal growth factor-like growth factor Binding (binding) of in fibroblast associated with stroke and neurodegenerative disease
4) Confidence 0.22 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2637876 Disease Relevance 1.13 Pain Relevance 0.33
We examined whether, heparin binding-epidermal growth factor-like growth factor (HB-EGF), a recently described member of the epidermal growth factor (EGF) family, might compete with an inhibitory opioid signal.
heparin binding-epidermal growth factor Spec (might) Binding (compete) of associated with opioid
5) Confidence 0.21 Published 1998 Journal Brain Res. Section Abstract Doc Link 9729296 Disease Relevance 0.15 Pain Relevance 1.07
Blockade of the internalization of DTS by the dominant-negative mutant dynamin, dynamin K44E, did not affect AC desensitization.
DTS Binding (internalization) of
6) Confidence 0.18 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17565992 Disease Relevance 0 Pain Relevance 0.50

General Comments

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