INT77339

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.36
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RRM2) nucleoplasm (RRM2) small molecule metabolic process (RRM2)
oxidoreductase activity (RRM2) cytoplasm (RRM2)
Anatomy Link Frequency
neurons 2
RRM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 71 100.00 Very High Very High Very High
Pain 28 99.84 Very High Very High Very High
wide dynamic range 2 99.84 Very High Very High Very High
Dorsal horn 10 95.68 Very High Very High Very High
Face pain 2 88.04 High High
referred pain 2 87.00 High High
Pain score 7 81.96 Quite High
nociceptor 2 25.00 Low Low
Opioid 24 5.00 Very Low Very Low Very Low
Morphine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 11 94.92 High High
Pain 24 88.24 High High
Facial Pain 2 88.04 High High
Referred Pain 2 87.00 High High
Post Operative Pain 2 5.00 Very Low Very Low Very Low
Stomach Cancer 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Colon Cancer 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
R1 and R2 can be evoked by innocuous stimuli, but only the R2 also by painful heat, suggesting that the R2 is mediated by wide dynamic range neurons (WDR) of the spinal trigeminal nucleus.
Positive_regulation (mediated) of R2 in neurons associated with pain and wide dynamic range
1) Confidence 0.41 Published 1998 Journal Brain Res. Section Abstract Doc Link 9729360 Disease Relevance 0 Pain Relevance 0.28
These results provide further evidence that the R2 is mediated by medullary WDR neurons and the R1 by pontine LTM neurons.
Positive_regulation (mediated) of R2 in neurons
2) Confidence 0.41 Published 1998 Journal Brain Res. Section Abstract Doc Link 9729360 Disease Relevance 0 Pain Relevance 0.37
R1- and R2-components can be evoked by innocuous stimuli, but only the R2 is elicited by painful heat.
Positive_regulation (elicited) of R2 associated with pain
3) Confidence 0.31 Published 1998 Journal Neuroreport Section Abstract Doc Link 9831453 Disease Relevance 0.51 Pain Relevance 0.58
While R1 remained unchanged, the R2 was facilitated by about 30%.
Positive_regulation (facilitated) of R2
4) Confidence 0.31 Published 1998 Journal Neuroreport Section Abstract Doc Link 9831453 Disease Relevance 0.47 Pain Relevance 0.54
1250G/1032A haplotype and the increased frequency of rescue analgesic administration in all patient subjects (R2?
Positive_regulation (increased) of R2 associated with analgesic
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738941 Disease Relevance 0.38 Pain Relevance 1.12

General Comments

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