INT77356

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Context Info
Confidence 0.63
First Reported 1998
Last Reported 1999
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Gnai1) GTPase activity (Gnai1) cytoplasm (Gnai1)
signal transducer activity (Gnai1) signal transduction (Gnai1) nucleus (Gnai1)
Anatomy Link Frequency
striatum 1
Gnai1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 3 89.44 High High
Potency 3 89.32 High High
Analgesic 2 89.00 High High
Morphine 2 88.52 High High
fortral 3 88.40 High High
analgesia 1 88.24 High High
MU agonist 1 75.00 Quite High
Enkephalin 1 70.48 Quite High
Intracerebroventricular 1 57.80 Quite High
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Bordatella Infection 1 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, no changes in Gialpha2 mRNA in mouse striatum were noted at any time after antisense treatment.
Neg (no) Positive_regulation (changes) of Gialpha2 in striatum
1) Confidence 0.63 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729412 Disease Relevance 0 Pain Relevance 0.95
These findings suggest that metabotropic sigma receptors are selectively coupled to Gi1 protein.
Positive_regulation (coupled) of Gi1
2) Confidence 0.04 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10400084 Disease Relevance 0.09 Pain Relevance 0.17

General Comments

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