INT77359

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Context Info
Confidence 0.56
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.33
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gstt1) cytoplasm (Gstt1)
Anatomy Link Frequency
stomach 1
Gstt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 18 99.68 Very High Very High Very High
aspirin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 75.00 Quite High
Cancer 6 68.16 Quite High
Gastrointestinal Neoplasms 2 33.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, enhancement of colonic GSTT1-1 levels seems to be a common working mechanism of NSAIDs.
Positive_regulation (enhancement) of GSTT1-1 associated with cinod
1) Confidence 0.56 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9729437 Disease Relevance 0.14 Pain Relevance 0.39
Colonic GSTT1-1 levels were elevated by all NSAIDs tested except for relafen (1.5-6.4x).
Positive_regulation (elevated) of GSTT1-1 associated with cinod
2) Confidence 0.56 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9729437 Disease Relevance 0.19 Pain Relevance 0.39
In conclusion, dietary anticarcinogens are capable of inducing rGSTT1-1 protein levels in the rat gastrointestinal tract, and are most pronounced in the stomach.
Positive_regulation (inducing) of rGSTT1-1 in stomach
3) Confidence 0.46 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9855024 Disease Relevance 0 Pain Relevance 0
Enhanced rGSTT1-1 protein levels might lead to an increase of enzyme activity and to a more efficient detoxification of carcinogens and thus could contribute to prevention of carcinogenesis.
Positive_regulation (Enhanced) of rGSTT1-1
4) Confidence 0.33 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9855024 Disease Relevance 0 Pain Relevance 0

General Comments

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