INT77396

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.04
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB1) plasma membrane (ARRB1) nucleus (ARRB1)
transcription factor binding (ARRB1) cytoplasm (ARRB1)
Anatomy Link Frequency
sciatic nerve 1
N18 1
ARRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 4 99.58 Very High Very High Very High
opioid receptor 6 99.32 Very High Very High Very High
allodynia 4 98.24 Very High Very High Very High
Sciatic nerve 1 97.74 Very High Very High Very High
tolerance 4 97.38 Very High Very High Very High
Morphine 5 97.18 Very High Very High Very High
Neuropathic pain 3 96.00 Very High Very High Very High
Delta opioid receptors 1 94.08 High High
gABA 2 86.60 High High
Kappa opioid receptor 1 86.16 High High
Disease Link Frequency Relevance Heat
Infection 252 99.08 Very High Very High Very High
Neuropathic Pain 7 98.24 Very High Very High Very High
Nervous System Injury 2 97.88 Very High Very High Very High
Targeted Disruption 12 96.96 Very High Very High Very High
Neuroblastoma 6 56.12 Quite High
Pituitary Cancer 2 55.36 Quite High
Dengue 33 50.00 Quite Low
Dengue Hemorrhagic Fever 27 5.00 Very Low Very Low Very Low
Fever 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, the siRNA knockdown of ACTR2, ARPC1B, ARPC3 (different subunits of the actin related 2/3 protein complex), ARRB1, DIAPH1, PIP5K1A and WASF2 genes that are important in actin polymerization have resulted in reduction of DENV infection.
Regulation (important) of ARRB1 associated with infection
1) Confidence 0.35 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.10 Pain Relevance 0
The development of morphine tolerance and sciatic nerve injury-induced allodynia after functional knockdown of spinal opioid receptors using antisense oligonucleotides targeting beta-arrestin was investigated.
Regulation (targeting) of beta-arrestin in sciatic nerve associated with nervous system injury, allodynia, tolerance, opioid receptor, sciatic nerve and morphine
2) Confidence 0.26 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12044633 Disease Relevance 0.61 Pain Relevance 1.16
Furthermore, mu opioid receptor became sensitive to beta-arr1 regulation following replacement of its carboxyl terminus with the corresponding portion of the delta receptor.
Regulation (regulation) of beta-arr1 associated with mu opioid receptor
3) Confidence 0.25 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9733719 Disease Relevance 0 Pain Relevance 0.68
The knock-down of ATP6V0A1 and CLTC (at concentration of 50 nM) produced the strongest inhibition of DENV infection. siRNA smart pool-based deconvolution assays targeting CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 and ARPC1B were also performed to ensure that inhibitory effects on DENV infection observed in the primary screen was specific and not due to off-target gene effects of the siRNA primary screen. 30 nM of each specific individual siRNA of the smart pool (4 specific siRNAs) directed against each of the respective genes were reverse transfected into RD cells and subsequently subjected to DENV infection.
Regulation (targeting) of ARRB1 associated with targeted disruption and infection
4) Confidence 0.21 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.72 Pain Relevance 0
Reverse-transfection of Huh 7 cells with siRNAs targeting CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 and ARPC1B showed dosage dependent reductions in the levels of the respective proteins when compared to the levels in the mock-transfected cells (Figure 3).
Regulation (targeting) of ARRB1
5) Confidence 0.21 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.50 Pain Relevance 0
N18 cells' GPCRs are also presumably tightly regulated based on the assortment of GRK, RGS and beta-arrestin mRNAs detected (figures 5 and 6).
Regulation (regulated) of beta-arrestin in N18
6) Confidence 0.14 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.06 Pain Relevance 0.30
Figures 5 and 6 show the mRNA levels of various types of GPCR signaling-related gene products such as the G proteins and a number of their targets and downstream effectors as well as proteins that regulate GPCR signaling, the GRK, beta-arrestin (ARRB) and RGS proteins.
Regulation (regulate) of beta-arrestin
7) Confidence 0.14 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.06 Pain Relevance 0.07

General Comments

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