INT77404

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 21
Disease Relevance 1.53
Pain Relevance 7.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB1) plasma membrane (ARRB1) nucleus (ARRB1)
transcription factor binding (ARRB1) cytoplasm (ARRB1)
Anatomy Link Frequency
embryonic kidney 3
AtT20 2
neuronal 1
ARRB1 (Homo sapiens)
ARRB1 - K220R (1)
Pain Link Frequency Relevance Heat
opioid receptor 58 100.00 Very High Very High Very High
mu opioid receptor 23 99.76 Very High Very High Very High
Opioid 14 99.62 Very High Very High Very High
agonist 41 99.40 Very High Very High Very High
Enkephalin 12 97.48 Very High Very High Very High
tolerance 12 91.76 High High
addiction 3 90.64 High High
Immobilon 16 89.04 High High
narcan 7 87.60 High High
antagonist 3 87.24 High High
Disease Link Frequency Relevance Heat
Infection 84 100.00 Very High Very High Very High
Bordatella Infection 3 92.32 High High
Neuroblastoma 16 88.80 High High
Dysmenorrhea 2 64.76 Quite High
Targeted Disruption 4 62.16 Quite High
Dengue 11 50.00 Quite Low
Dengue Hemorrhagic Fever 9 5.00 Very Low Very Low Very Low
Pituitary Cancer 3 5.00 Very Low Very Low Very Low
Fever 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In parallel, kappa and delta receptor-mediated G protein activation was also remarkably attenuated by overexpression of beta-arr1, while the mu-agonist-stimulated response remained intact.
Gene_expression (overexpression) of beta-arr1 associated with agonist
1) Confidence 0.62 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9733719 Disease Relevance 0 Pain Relevance 0.71
In contrast, coexpression of beta-arr1 with mu opioid receptor did not affect the concentration-effect relationship of mu-agonist [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin.
Gene_expression (coexpression) of beta-arr1 associated with agonist, mu opioid receptor and enkephalin
2) Confidence 0.62 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9733719 Disease Relevance 0 Pain Relevance 0.68
The role of beta-arrestin 1 (beta-arr1) in regulation of responsiveness of kappa, delta, and mu opioid receptors has been investigated in human embryonic kidney 293 cells cotransfected with opioid receptor and beta-arr1.
Gene_expression (cotransfected) of beta-arr1 in embryonic kidney associated with mu opioid receptor and opioid receptor
3) Confidence 0.62 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9733719 Disease Relevance 0 Pain Relevance 0.51
Herkinorin (HERK), unlike DAMGO, does not recruit beta-arrestin and promote mu-receptor internalization, even in cells that over express beta-arrestin.
Gene_expression (express) of beta-arrestin
4) Confidence 0.57 Published 2007 Journal Synapse Section Abstract Doc Link 17152090 Disease Relevance 0 Pain Relevance 0.51
To further validate the findings obtained from the initial screen, we have selected these genes (CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 & ARPC1B) for re-confirming their inhibitory effects on DENV infection.
Gene_expression (infection) of ARRB1 associated with infection
5) Confidence 0.52 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.53 Pain Relevance 0
In COS-7 cells, which express low levels of GRK2 and beta-arrestin, overexpression of GRK2 and beta-arrestin increased receptor phosphorylation, desensitization, and internalization to the high levels observed in human embryonic kidney 293 cells.
Gene_expression (express) of beta-arrestin in embryonic kidney
6) Confidence 0.49 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0.06 Pain Relevance 0.14
In COS-7 cells, which express low levels of GRK2 and beta-arrestin, overexpression of GRK2 and beta-arrestin increased receptor phosphorylation, desensitization, and internalization to the high levels observed in human embryonic kidney 293 cells.
Gene_expression (overexpression) of beta-arrestin in embryonic kidney
7) Confidence 0.49 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0.06 Pain Relevance 0.13
Expression of human beta-arr1 attenuated kappa and delta opioid receptor subtype-mediated inhibition of cAMP production and resulted in a 100-fold increase of EC50 values for kappa-agonist U69593 and delta-agonist [D-Pen2, D-Pen5]enkephalin and 30-40% reduction of their maximal responses.
Gene_expression (Expression) of beta-arr1 associated with agonist, enkephalin and opioid receptor
8) Confidence 0.48 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9733719 Disease Relevance 0 Pain Relevance 0.54
Moreover, this method also allows to counteract the phenotypic drift and to maintain a high-purity selection of SK-N-BE cells expressing beta-arrestin1-GFP.
Gene_expression (expressing) of beta-arrestin1-GFP
9) Confidence 0.42 Published 2006 Journal Brain Res. Section Abstract Doc Link 16938287 Disease Relevance 0.07 Pain Relevance 0.30
In this work, we describe a method, based on fluorescence-activated cell sorting (FACS), to select and maintain a high proportion of transfected SK-N-BE cells (a neuronal cell line endogenously expressing human Delta-Opioid Receptor (hDOR)), expressing the beta-arrestin1 fused to green fluorescent protein (GFP).
Gene_expression (expressing) of beta-arrestin1 in neuronal associated with opioid
10) Confidence 0.42 Published 2006 Journal Brain Res. Section Abstract Doc Link 16938287 Disease Relevance 0.07 Pain Relevance 0.39
While in functional experiments, we were not able to observe a major effect in non-sorted SK-N-BE cells expressing beta-arrestin1-GFP, the enrichment by 18-fold with FACS resulted in a robust increase of beta-arrestin1-GFP expression associated with strong hDOR desensitization.
Gene_expression (expressing) of beta-arrestin1-GFP
11) Confidence 0.42 Published 2006 Journal Brain Res. Section Abstract Doc Link 16938287 Disease Relevance 0.07 Pain Relevance 0.35
While in functional experiments, we were not able to observe a major effect in non-sorted SK-N-BE cells expressing beta-arrestin1-GFP, the enrichment by 18-fold with FACS resulted in a robust increase of beta-arrestin1-GFP expression associated with strong hDOR desensitization.
Gene_expression (expression) of beta-arrestin1-GFP
12) Confidence 0.37 Published 2006 Journal Brain Res. Section Abstract Doc Link 16938287 Disease Relevance 0.07 Pain Relevance 0.31
While in functional experiments, we were not able to observe a major effect in non-sorted SK-N-BE cells expressing beta-arrestin1-GFP, the enrichment by 18-fold with FACS resulted in a robust increase of beta-arrestin1-GFP expression associated with strong hDOR desensitization.
Gene_expression (expressing) of beta-arrestin1-GFP
13) Confidence 0.37 Published 2006 Journal Brain Res. Section Abstract Doc Link 16938287 Disease Relevance 0.07 Pain Relevance 0.35
Moreover, this method also allows to counteract the phenotypic drift and to maintain a high-purity selection of SK-N-BE cells expressing beta-arrestin1-GFP.
Gene_expression (expressing) of beta-arrestin1-GFP
14) Confidence 0.37 Published 2006 Journal Brain Res. Section Abstract Doc Link 16938287 Disease Relevance 0.07 Pain Relevance 0.30
AtT20 cells were the only ones to not have significant levels of beta-arrestin1 (Arrb1) or GRK3-5.
Gene_expression (levels) of Arrb1 in AtT20
15) Confidence 0.35 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0 Pain Relevance 0.04
AtT20 cells were the only ones to not have significant levels of beta-arrestin1 (Arrb1) or GRK3-5.
Gene_expression (levels) of beta-arrestin1 in AtT20
16) Confidence 0.35 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0 Pain Relevance 0.04
While in functional experiments, we were not able to observe a major effect in non-sorted SK-N-BE cells expressing beta-arrestin1-GFP, the enrichment by 18-fold with FACS resulted in a robust increase of beta-arrestin1-GFP expression associated with strong hDOR desensitization.
Gene_expression (expression) of beta-arrestin1-GFP
17) Confidence 0.32 Published 2006 Journal Brain Res. Section Abstract Doc Link 16938287 Disease Relevance 0.07 Pain Relevance 0.31
Their beta-arrestin, RGS protein, and GRK levels suggest the capacity to highly regulate GPCR signaling as well.
Gene_expression (levels) of beta-arrestin
18) Confidence 0.31 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.09 Pain Relevance 0.29
Co-expression of dominant negative mutants of beta-arrestin or dynamin I, which greatly reduced U50,488H-induced internalization, did not affect MAP kinase activation by the agonist.
Gene_expression (Co-expression) of beta-arrestin associated with agonist
19) Confidence 0.18 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10207034 Disease Relevance 0.08 Pain Relevance 0.42
While co-expression of the wild type GRK2, beta-arrestin, or dynamin I had no effect on kappa receptor internalization, co-expression of the dominant negative mutants GRK2-K220R, beta-arrestin (319-418), or dynamin I-K44A significantly inhibited receptor internalization.
Gene_expression (co-expression) of beta-arrestin (K220R)
20) Confidence 0.18 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10207034 Disease Relevance 0.09 Pain Relevance 0.47

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