INT77407
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
MOR expression is regulated at the transcriptional and post-transcriptional levels. | |||||||||||||||
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Tissue samples from 11 fatalities due to opiate overdose and five normal subjects with different causes of death were analysed in order to elucidate whether chronic opiate abuse is followed by a regulation of MOR1 expression. | |||||||||||||||
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However, the molecular processes that regulate the expression of the mu opioid receptor gene in immune cells are not well understood. | |||||||||||||||
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However, the measured M. edulis pedal ganglia MOR expression demonstrated that ganglia significantly (0.77+/-0.05, p<0.001) down regulated their mu opiate receptor mRNA expression after 24h exposure to the cold water. | |||||||||||||||
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Temporal changes in mu opiate receptor expression were also examined over 24 hours. | |||||||||||||||
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We propose that the opioid-induced regulation of MOR mRNA expression is mediated by reduced binding of the transcription factors NFkappaB and AP-1 to the promoter region on the MOR gene. | |||||||||||||||
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Opioid-induced regulation of mu-opioid receptor gene expression in the MCF-7 breast cancer cell line. | |||||||||||||||
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Besides direct actions on the neurons themselves, opiates directly affect MOR-expressing astrocytes and microglia. | |||||||||||||||
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To investigate whether the changes in MOR mRNA expression paralleled changes in MOR receptor function, intracellular cAMP accumulation in SHSY-5Y cells was measured. | |||||||||||||||
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The aim of the study was to investigate the presence of opioid receptor types in human breast adenocarcinoma MCF-7 cells and to characterize the changes in MOR expression induced by opioid agonist and antagonist treatment. | |||||||||||||||
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To study the regulatory elements that control expression of the human MOR (hMOR) gene, 2325 bp of the 5'-regulatory sequence of the hMOR gene were cloned and sequenced. | |||||||||||||||
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The expression of opioid receptors can be up and down regulated, but little is known about molecular processes that regulate expression of the MOR gene. | |||||||||||||||
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Studies were performed to examine the effects of specific retinoid receptor activation on mu opioid receptor (MOR) production by phytohemagglutinin (PHA)-stimulated U937 cells, a mononuclear cell line. | |||||||||||||||
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Effects of cold stress on morphine-induced nitric oxide production and mu-opiate receptor gene expression in Mytilus edulis pedal ganglia. | |||||||||||||||
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Cytokines, mediators typically released from cells of the immune system, are potent regulators of mu-opioid receptor gene expression. | |||||||||||||||
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Knowledge about the mechanisms controling the expression of the mu-opioid receptor gene in neuronal and immune cells is crucial to understand the dynamics and the activity of this receptor. | |||||||||||||||
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Therefore, in the present study we have investigated whether this mutation might affect the binding affinity, potency, and/or the agonist-induced desensitization, internalization and resensitization of the human mu-opioid receptor stably expressed in human embryonic kidney 293 cells. | |||||||||||||||
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RESULTS: Mu opiate receptor gene expression was significantly down regulated in cells treated with SNAP at 30 min, and superoxide dismutase blocked the effect of SNAP. | |||||||||||||||
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Real-time RT-PCR measurement of the modulation of Mu opiate receptor expression by nitric oxide in human mononuclear cells. | |||||||||||||||
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However, the specific molecular mechanism by which immunodeficiency virus infection impacts regulation of the MOR gene expression in lymphocytes is still unclear. | |||||||||||||||
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