INT77407

Context Info Confidence 0.62 First Reported 1998 Last Reported 2010 Negated 5 Speculated 7 Reported most in Abstract Documents 51 Total Number 58 Disease Relevance 12.58 Pain Relevance 35.75

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1) signal transducer activity (OPRM1)

Anatomy Link Frequency LMOR 8 ganglia 8 mononuclear cell 6 immune cells 5 MCF-7 4 OPRM1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 369 100.00 Morphine 255 100.00 agonist 231 100.00 mu opioid receptor 218 100.00 Opioid 172 100.00 antagonist 152 100.00 narcan 116 100.00 opiate 57 100.00 Potency 31 100.00 Opioid receptor 1 29 100.00

Disease Link Frequency Relevance Heat Nervous System Injury 16 100.00 Stress 14 100.00 Infection 12 99.82 Injury 19 99.68 Immunodeficiency 3 99.50 Breast Cancer 3 99.44 Adenocarcinoma 3 99.26 Eczema 10 98.80 Pain 39 98.60 Death 11 98.34

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MOR expression is regulated at the transcriptional and post-transcriptional levels.

Regulation (regulated) of Gene_expression (expression) of MOR associated with mu opioid receptor

1) Confidence 0.62 Published 2010 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19438807 Disease Relevance 0 Pain Relevance 0.51

Tissue samples from 11 fatalities due to opiate overdose and five normal subjects with different causes of death were analysed in order to elucidate whether chronic opiate abuse is followed by a regulation of MOR1 expression.

Spec (whether) Regulation (regulation) of Gene_expression (expression) of MOR1 associated with opiate, death and overdose

2) Confidence 0.62 Published 2004 Journal Forensic Sci. Int. Section Abstract Doc Link 15013161 Disease Relevance 0.29 Pain Relevance 0.54

However, the molecular processes that regulate the expression of the mu opioid receptor gene in immune cells are not well understood.

Regulation (regulate) of Gene_expression (expression) of mu opioid receptor in immune cells associated with mu opioid receptor

3) Confidence 0.62 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15988758 Disease Relevance 0 Pain Relevance 0.43

However, the measured M. edulis pedal ganglia MOR expression demonstrated that ganglia significantly (0.77+/-0.05, p<0.001) down regulated their mu opiate receptor mRNA expression after 24h exposure to the cold water.

Regulation (regulated) of Gene_expression (expression) of mu opiate receptor mRNA in ganglia

4) Confidence 0.61 Published 2003 Journal Neuro Endocrinol. Lett. Section Body Doc Link 12743536 Disease Relevance 0.08 Pain Relevance 0

Temporal changes in mu opiate receptor expression were also examined over 24 hours.

Regulation (changes) of Gene_expression (expression) of mu opiate receptor

5) Confidence 0.61 Published 2003 Journal Neuro Endocrinol. Lett. Section Body Doc Link 12743536 Disease Relevance 0.10 Pain Relevance 0

We propose that the opioid-induced regulation of MOR mRNA expression is mediated by reduced binding of the transcription factors NFkappaB and AP-1 to the promoter region on the MOR gene.

Regulation (regulation) of Gene_expression (expression) of MOR mRNA associated with opioid

6) Confidence 0.60 Published 2008 Journal Biochem. Cell Biol. Section Abstract Doc Link 18523482 Disease Relevance 0.14 Pain Relevance 0.96

Opioid-induced regulation of mu-opioid receptor gene expression in the MCF-7 breast cancer cell line.

Regulation (regulation) of Gene_expression (expression) of mu-opioid receptor gene in MCF-7 associated with breast cancer, opioid receptor and opioid

7) Confidence 0.60 Published 2008 Journal Biochem. Cell Biol. Section Title Doc Link 18523482 Disease Relevance 0.19 Pain Relevance 0.96

Besides direct actions on the neurons themselves, opiates directly affect MOR-expressing astrocytes and microglia.

Regulation (affect) of Gene_expression (expressing) of MOR in astrocytes associated with mu opioid receptor and opiate

8) Confidence 0.60 Published 2005 Journal Neurotox Res Section Abstract Doc Link 16260386 Disease Relevance 1.20 Pain Relevance 1.14

To investigate whether the changes in MOR mRNA expression paralleled changes in MOR receptor function, intracellular cAMP accumulation in SHSY-5Y cells was measured.

Spec (whether) Regulation (changes) of Gene_expression (expression) of MOR mRNA associated with opioid receptor

9) Confidence 0.60 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12754318 Disease Relevance 0.48 Pain Relevance 1.35

The aim of the study was to investigate the presence of opioid receptor types in human breast adenocarcinoma MCF-7 cells and to characterize the changes in MOR expression induced by opioid agonist and antagonist treatment.

Regulation (changes) of Gene_expression (expression) of MOR in MCF-7 associated with adenocarcinoma, mu agonist, antagonist and opioid receptor

10) Confidence 0.60 Published 2008 Journal Biochem. Cell Biol. Section Abstract Doc Link 18523482 Disease Relevance 0.17 Pain Relevance 0.65

To study the regulatory elements that control expression of the human MOR (hMOR) gene, 2325 bp of the 5'-regulatory sequence of the hMOR gene were cloned and sequenced.

Regulation (control) of Gene_expression (expression) of hMOR associated with mu opioid receptor

11) Confidence 0.59 Published 2001 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 11936871 Disease Relevance 0.06 Pain Relevance 0.57

The expression of opioid receptors can be up and down regulated, but little is known about molecular processes that regulate expression of the MOR gene.

Regulation (regulate) of Gene_expression (expression) of MOR associated with mu opioid receptor and opioid receptor

12) Confidence 0.59 Published 2001 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 11936871 Disease Relevance 0.05 Pain Relevance 0.57

Studies were performed to examine the effects of specific retinoid receptor activation on mu opioid receptor (MOR) production by phytohemagglutinin (PHA)-stimulated U937 cells, a mononuclear cell line.

Spec (examine) Regulation (effects) of Gene_expression (production) of mu opioid receptor in mononuclear cell associated with mu opioid receptor

13) Confidence 0.55 Published 2005 Journal J. Neurovirol. Section Abstract Doc Link 16036794 Disease Relevance 0.38 Pain Relevance 0.64

Effects of cold stress on morphine-induced nitric oxide production and mu-opiate receptor gene expression in Mytilus edulis pedal ganglia.

Regulation (Effects) of Gene_expression (expression) of opiate receptor in ganglia associated with stress, opiate and morphine

14) Confidence 0.53 Published 2003 Journal Neuro Endocrinol. Lett. Section Title Doc Link 12743536 Disease Relevance 0.10 Pain Relevance 0.58

Cytokines, mediators typically released from cells of the immune system, are potent regulators of mu-opioid receptor gene expression.

Regulation (regulators) of Gene_expression (expression) of mu-opioid receptor gene in immune system associated with opioid receptor and cytokine

15) Confidence 0.52 Published 2009 Journal Front Biosci (Schol Ed) Section Abstract Doc Link 19482692 Disease Relevance 0.23 Pain Relevance 0.72

Knowledge about the mechanisms controling the expression of the mu-opioid receptor gene in neuronal and immune cells is crucial to understand the dynamics and the activity of this receptor.

Regulation (controling) of Gene_expression (expression) of mu-opioid receptor gene in immune cells associated with opioid receptor

16) Confidence 0.52 Published 2009 Journal Front Biosci (Schol Ed) Section Abstract Doc Link 19482692 Disease Relevance 0.20 Pain Relevance 0.75

Therefore, in the present study we have investigated whether this mutation might affect the binding affinity, potency, and/or the agonist-induced desensitization, internalization and resensitization of the human mu-opioid receptor stably expressed in human embryonic kidney 293 cells.

Spec (might) Regulation (affect) of Gene_expression (expressed) of mu-opioid receptor in embryonic kidney associated with agonist, opioid receptor and potency

17) Confidence 0.50 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15086512 Disease Relevance 0.19 Pain Relevance 1.02

RESULTS: Mu opiate receptor gene expression was significantly down regulated in cells treated with SNAP at 30 min, and superoxide dismutase blocked the effect of SNAP.

Regulation (regulated) of Gene_expression (expression) of Mu opiate receptor

18) Confidence 0.47 Published 2001 Journal Med. Sci. Monit. Section Body Doc Link 11687719 Disease Relevance 0 Pain Relevance 0

Real-time RT-PCR measurement of the modulation of Mu opiate receptor expression by nitric oxide in human mononuclear cells.

Regulation (modulation) of Gene_expression (expression) of Mu opiate receptor in mononuclear cells associated with opioid receptor 1

19) Confidence 0.47 Published 2001 Journal Med. Sci. Monit. Section Title Doc Link 11687719 Disease Relevance 0 Pain Relevance 0.29

However, the specific molecular mechanism by which immunodeficiency virus infection impacts regulation of the MOR gene expression in lymphocytes is still unclear.

Regulation (regulation) of Gene_expression (expression) of MOR gene in lymphocytes associated with mu opioid receptor, infection and immunodeficiency

20) Confidence 0.46 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.61 Pain Relevance 0.34

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