INT77408

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.31
Pain Relevance 6.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB1) plasma membrane (ARRB1) nucleus (ARRB1)
transcription factor binding (ARRB1) cytoplasm (ARRB1)
Anatomy Link Frequency
plasma 2
I3L 2
pits 1
ARRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 81 100.00 Very High Very High Very High
substance P 20 99.74 Very High Very High Very High
Delta opioid receptors 5 99.36 Very High Very High Very High
agonist 14 98.24 Very High Very High Very High
Kappa opioid receptor 1 92.84 High High
Morphine 6 92.32 High High
Enkephalin 7 88.64 High High
tolerance 7 84.80 Quite High
addiction 5 83.68 Quite High
mu opioid receptor 8 83.44 Quite High
Disease Link Frequency Relevance Heat
Dysmenorrhea 2 76.20 Quite High
Nociception 4 65.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that ERK/MAP kinase activity prevents opioid receptor desensitization and sequestration by blocking arrestin 2 interaction with activated DORs.
arrestin 2 Binding (interaction) of associated with delta opioid receptors and opioid receptor
1) Confidence 0.36 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 0.72
Herkinorin (HERK), unlike DAMGO, does not recruit beta-arrestin and promote mu-receptor internalization, even in cells that over express beta-arrestin.
beta-arrestin Neg (not) Binding (recruit) of
2) Confidence 0.32 Published 2007 Journal Synapse Section Abstract Doc Link 17152090 Disease Relevance 0 Pain Relevance 0.47
By contrast, beta-arrestin/OTR interactions initiated only at 10 sec, reached plateau levels at 120 sec, but remained stable with little decrease thereafter.
beta-arrestin Binding (interactions) of
3) Confidence 0.31 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0.08 Pain Relevance 0.16
These results suggest that receptor carboxyl terminus and its phosphorylation play an important role in the interaction of beta-arr1 and opioid receptors.
beta-arr1 Binding (interaction) of associated with opioid receptor
4) Confidence 0.30 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9733719 Disease Relevance 0 Pain Relevance 0.52
In vitro data from glutathione-S-transferase pull-down assay showed that the carboxyl terminus (CT) and the third intracellular loop (I3L) of DOR are both capable of and either domain is sufficient for binding to beta-arrestin 1 and 2.
beta-arrestin Binding (binding) of in I3L associated with opioid receptor
5) Confidence 0.25 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11259507 Disease Relevance 0 Pain Relevance 0.64
Surface plasmon resonance determination further revealed that binding of CT and I3L of DOR to beta-arrestin is additive, suggesting these two domains bind at distinctly different sites on beta-arrestin without considerable spatial hindrance.
beta-arrestin Binding (bind) of in I3L associated with opioid receptor
6) Confidence 0.25 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11259507 Disease Relevance 0 Pain Relevance 0.61
These data characterize the temporal and causal relationship of GRK-2/OTR and beta-arrestin/OTR interactions and establish GRK/OTR interaction as a prerequisite for beta-arrestin-mediated OTR desensitization.
beta-arrestin Binding (interactions) of
7) Confidence 0.24 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0 Pain Relevance 0.03
Interestingly, in cells coexpressing MOR1 and NK1 both DAMGO and SP induced the recruitment of beta-arrestin to the plasma membrane and cointernalization of NK1-MOR1 heterodimers with beta-arrestin into the same endosomal compartment.
beta-arrestin Binding (cointernalization) of in plasma associated with opioid receptor and substance p
8) Confidence 0.01 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14532289 Disease Relevance 0.05 Pain Relevance 0.77
Interestingly, in cells coexpressing MOR1 and NK1 both DAMGO and SP induced the recruitment of beta-arrestin to the plasma membrane and cointernalization of NK1-MOR1 heterodimers with beta-arrestin into the same endosomal compartment.
beta-arrestin Binding (recruitment) of in plasma associated with opioid receptor and substance p
9) Confidence 0.01 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14532289 Disease Relevance 0.05 Pain Relevance 0.85
In cells expressing NK1 alone, beta-arrestin internalizes with the receptor into endosomes.
beta-arrestin Binding (internalizes) of
10) Confidence 0.01 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14532289 Disease Relevance 0.06 Pain Relevance 0.86
In cells expressing MOR1 alone, beta-arrestin directs the receptors to clathrin-coated pits, but does not internalize with the receptor.
beta-arrestin Neg (not) Binding (internalize) of in pits associated with opioid receptor
11) Confidence 0.01 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 14532289 Disease Relevance 0.07 Pain Relevance 0.88

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