INT77410

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Context Info
Confidence 0.55
First Reported 1998
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0.21
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB1) plasma membrane (ARRB1) nucleus (ARRB1)
transcription factor binding (ARRB1) cytoplasm (ARRB1)
Anatomy Link Frequency
embryonic kidney 4
ARRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 20 100.00 Very High Very High Very High
agonist 10 99.40 Very High Very High Very High
mu opioid receptor 10 98.82 Very High Very High Very High
Enkephalin 6 95.84 Very High Very High Very High
Opioid 2 88.68 High High
Delta opioid receptors 2 81.60 Quite High
Morphine 4 74.92 Quite High
Dismenorea 1 62.92 Quite High
Kappa opioid receptor 2 52.56 Quite High
tolerance 2 36.76 Quite Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 75.00 Quite High
Dysmenorrhea 1 62.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In parallel, kappa and delta receptor-mediated G protein activation was also remarkably attenuated by overexpression of beta-arr1, while the mu-agonist-stimulated response remained intact.
Positive_regulation (overexpression) of Gene_expression (overexpression) of beta-arr1 associated with agonist
1) Confidence 0.55 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9733719 Disease Relevance 0 Pain Relevance 0.71
In COS-7 cells, which express low levels of GRK2 and beta-arrestin, overexpression of GRK2 and beta-arrestin increased receptor phosphorylation, desensitization, and internalization to the high levels observed in human embryonic kidney 293 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of beta-arrestin in embryonic kidney
2) Confidence 0.44 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0.06 Pain Relevance 0.13
The role of beta-arrestin 1 (beta-arr1) in regulation of responsiveness of kappa, delta, and mu opioid receptors has been investigated in human embryonic kidney 293 cells cotransfected with opioid receptor and beta-arr1.
Spec (investigated) Positive_regulation (cotransfected) of Gene_expression (cotransfected) of beta-arr1 in embryonic kidney associated with mu opioid receptor and opioid receptor
3) Confidence 0.40 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9733719 Disease Relevance 0 Pain Relevance 0.51
While in functional experiments, we were not able to observe a major effect in non-sorted SK-N-BE cells expressing beta-arrestin1-GFP, the enrichment by 18-fold with FACS resulted in a robust increase of beta-arrestin1-GFP expression associated with strong hDOR desensitization.
Positive_regulation (increase) of Gene_expression (expression) of beta-arrestin1-GFP
4) Confidence 0.33 Published 2006 Journal Brain Res. Section Abstract Doc Link 16938287 Disease Relevance 0.07 Pain Relevance 0.31
While in functional experiments, we were not able to observe a major effect in non-sorted SK-N-BE cells expressing beta-arrestin1-GFP, the enrichment by 18-fold with FACS resulted in a robust increase of beta-arrestin1-GFP expression associated with strong hDOR desensitization.
Positive_regulation (increase) of Gene_expression (expression) of beta-arrestin1-GFP
5) Confidence 0.24 Published 2006 Journal Brain Res. Section Abstract Doc Link 16938287 Disease Relevance 0.07 Pain Relevance 0.31

General Comments

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