INT77411

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.61
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARRB1) plasma membrane (ARRB1) nucleus (ARRB1)
transcription factor binding (ARRB1) cytoplasm (ARRB1)
ARRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 4 100.00 Very High Very High Very High
agonist 9 98.80 Very High Very High Very High
Enkephalin 3 97.48 Very High Very High Very High
Immobilon 3 95.84 Very High Very High Very High
opioid receptor 4 90.76 High High
Kappa opioid receptor 5 75.00 Quite High
narcan 2 73.20 Quite High
antagonist 1 72.84 Quite High
Delta opioid receptors 1 64.00 Quite High
Opioid 1 40.24 Quite Low
Disease Link Frequency Relevance Heat
Infection 84 100.00 Very High Very High Very High
Bordatella Infection 1 77.92 Quite High
Targeted Disruption 4 62.16 Quite High
Dengue 11 50.00 Quite Low
Dengue Hemorrhagic Fever 9 5.00 Very Low Very Low Very Low
Fever 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Viral Meningitis 3 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Myalgia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, coexpression of beta-arr1 with mu opioid receptor did not affect the concentration-effect relationship of mu-agonist [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin.
Neg (not) Regulation (affect) of Gene_expression (coexpression) of beta-arr1 associated with agonist, mu opioid receptor and enkephalin
1) Confidence 0.36 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9733719 Disease Relevance 0 Pain Relevance 0.69
To further validate the findings obtained from the initial screen, we have selected these genes (CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 & ARPC1B) for re-confirming their inhibitory effects on DENV infection.
Regulation (effects) of Gene_expression (infection) of ARRB1 associated with infection
2) Confidence 0.35 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.53 Pain Relevance 0
Co-expression of dominant negative mutants of beta-arrestin or dynamin I, which greatly reduced U50,488H-induced internalization, did not affect MAP kinase activation by the agonist.
Neg (not) Regulation (affect) of Gene_expression (Co-expression) of beta-arrestin associated with agonist
3) Confidence 0.11 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10207034 Disease Relevance 0.08 Pain Relevance 0.43

General Comments

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