INT77416

Context Info Confidence 0.79 First Reported 1998 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.79 Pain Relevance 0.36

nucleus (ZGLP1)

Anatomy Link Frequency ileum 2 saliva 1 gut 1 ZGLP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Endocannabinoid 10 80.36 agonist 10 76.96 antagonist 2 68.20 Neurotransmitter 4 54.40 Inflammation 320 50.00 Paracetamol 3 45.68 Dopamine 4 39.20 nud 3 32.88 dopamine receptor 2 29.44 addiction 2 21.44

Disease Link Frequency Relevance Heat Monsters 1 96.88 Disease 11 95.96 Obesity 233 89.60 Weight Gain 5 88.00 Appetite Loss 16 84.88 Diabetes Mellitus 111 80.48 Overnutrition 15 78.80 INFLAMMATION 360 50.00 Insulin Resistance 24 46.88 Dyspepsia 3 32.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The gut peptide glucagon-like peptide 1(7-36) amide (GLP-1) is released into the circulation after food intake.

Localization (released) of GLP-1 in gut

1) Confidence 0.79 Published 1998 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 9734726 Disease Relevance 0.22 Pain Relevance 0

Exendin-4 (EX-4), an incretin-mimetic peptide hormone (containing 39 aminoacid residues) having GLP-1 like action[34], is secreted in the saliva (oral secretions)[3–6] and concentrated in the tail[3] of Gila monster lizard (Heloderma suspectum).

Localization (secreted) of GLP-1 in saliva associated with monsters

2) Confidence 0.20 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 0.85 Pain Relevance 0.06

Unlike other gastric bypass methods, this surgery also increases the release of gut hormones such as PYY and GLP-1 from the L-cells in the ileum, to give a profound degree of satiety [91].

Localization (release) of GLP-1 in ileum

3) Confidence 0.06 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2952901 Disease Relevance 0.61 Pain Relevance 0.17

As mentioned earlier, much of the success of gastric bypass surgery is related to the increase in satiety hormones (PYY and GLP-1) released from the ileum.

Localization (released) of GLP-1 in ileum

4) Confidence 0.05 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2952901 Disease Relevance 0.12 Pain Relevance 0.13

General Comments

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