INT77427

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Context Info
Confidence 0.26
First Reported 1998
Last Reported 2010
Negated 1
Speculated 6
Reported most in Body
Documents 17
Total Number 22
Disease Relevance 10.03
Pain Relevance 6.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
plasma 6
platelet 4
macrophages 3
cartilage 2
monocytes 1
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 168 100.00 Very High Very High Very High
COX-2 inhibitor 81 100.00 Very High Very High Very High
Inflammatory response 12 100.00 Very High Very High Very High
Inflammation 134 98.76 Very High Very High Very High
COX2 5 98.68 Very High Very High Very High
Osteoarthritis 127 98.24 Very High Very High Very High
Analgesic 9 95.52 Very High Very High Very High
acular 2 92.56 High High
aspirin 25 92.24 High High
Pain 30 91.44 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 184 100.00 Very High Very High Very High
Leg Ulcer 3 99.92 Very High Very High Very High
Disease 78 99.84 Very High Very High Very High
Breast Cancer 12 99.84 Very High Very High Very High
Creutzfeldt Jakob Disease 3 99.56 Very High Very High Very High
Skin Ulcer 6 99.16 Very High Very High Very High
Atherosclerosis 37 98.40 Very High Very High Very High
Osteoarthritis 128 98.24 Very High Very High Very High
Pre-eclampsia 33 97.96 Very High Very High Very High
Disorder Of Lipid Metabolism 8 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COX-2 selective inhibitors could therefore be effective in the treatment of chronic venous ulcers.
Regulation (effective) of Negative_regulation (inhibitors) of COX associated with skin ulcer
1) Confidence 0.26 Published 2001 Journal J. Pathol. Section Abstract Doc Link 11745699 Disease Relevance 1.11 Pain Relevance 0.29
Since the discovery of a second isoenzyme of cyclooxygenase (COX)-2, it has been hypothesized that the antiinflammatory effects of non-steroidal antiinflammatory drugs (NSAIDs) are dependent on their inhibition of COX-2, whereas inhibition of constitutive COX-1 is responsible for their gastric and renal side effects as well as for inhibition of platelet activation.
Regulation (responsible) of Negative_regulation (inhibition) of COX in platelet associated with inflammation and cinod
2) Confidence 0.19 Published 1999 Journal Drugs Today Section Abstract Doc Link 12973430 Disease Relevance 0.20 Pain Relevance 0.18
revealed that a dual inhibitor against LOX/COX is more effective than a
Regulation (effective) of Negative_regulation (inhibitor) of COX
3) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2652614 Disease Relevance 0.99 Pain Relevance 0.16
Therefore, we assessed the effects of meloxicam, a selective inhibitor of COX-2, and indomethacin, an unselective inhibitor of COX-1 and COX-2, on furosemide stimulated plasma renin activity (PRA).
Regulation (effects) of Negative_regulation (inhibitor) of COX in plasma
4) Confidence 0.15 Published 1998 Journal J. Investig. Med. Section Abstract Doc Link 9737091 Disease Relevance 0.09 Pain Relevance 0.19
Therefore, we assessed the effects of meloxicam, a selective inhibitor of COX-2, and indomethacin, an unselective inhibitor of COX-1 and COX-2, on furosemide stimulated plasma renin activity (PRA).
Regulation (effects) of Negative_regulation (inhibitor) of COX in plasma
5) Confidence 0.15 Published 1998 Journal J. Investig. Med. Section Abstract Doc Link 9737091 Disease Relevance 0.09 Pain Relevance 0.19
Therefore, we assessed the effects of meloxicam, a selective inhibitor of COX-2, and indomethacin, an unselective inhibitor of COX-1 and COX-2, on furosemide stimulated plasma renin activity (PRA).
Regulation (effects) of Negative_regulation (inhibitor) of COX in plasma
6) Confidence 0.15 Published 1998 Journal J. Investig. Med. Section Abstract Doc Link 9737091 Disease Relevance 0.09 Pain Relevance 0.19
Since the discovery of a second isoenzyme of cyclooxygenase (COX)-2, it has been hypothesized that the antiinflammatory effects of non-steroidal antiinflammatory drugs (NSAIDs) are dependent on their inhibition of COX-2, whereas inhibition of constitutive COX-1 is responsible for their gastric and renal side effects as well as for inhibition of platelet activation.
Regulation (dependent) of Negative_regulation (inhibition) of COX in platelet associated with inflammation and cinod
7) Confidence 0.14 Published 1999 Journal Drugs Today Section Abstract Doc Link 12973430 Disease Relevance 0.20 Pain Relevance 0.18
Several studies have shown that COX inhibitors have an effect on cartilage metabolism.
Regulation (effect) of Negative_regulation (inhibitors) of COX in cartilage
8) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246251 Disease Relevance 0.29 Pain Relevance 0.19
However, LOX inhibitors have a more potent effect on cell growth in vitro than COX inhibitors on constitutively
Regulation (effect) of Negative_regulation (inhibitors) of COX
9) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2652614 Disease Relevance 0.64 Pain Relevance 0.24
These results suggest that the effect of COX inhibitors on aromatase occurs at the transcriptional level.
Regulation (effect) of Negative_regulation (inhibitors) of COX
10) Confidence 0.13 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.39 Pain Relevance 0.31
Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention.
Spec (possible) Regulation (role) of Negative_regulation (inhibitors) of COX associated with breast cancer, cox2 and cox-2 inhibitor
11) Confidence 0.12 Published 2002 Journal Ann. Oncol. Section Title Doc Link 12075734 Disease Relevance 0.70 Pain Relevance 0.46
Reduction in ABCA1 combined with reduction in 27-hydroxylase as a result of COX inhibition could create a microenvironment within the vessel wall where cholesterol efflux is compromised.
Regulation (result) of Negative_regulation (inhibition) of COX
12) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.30 Pain Relevance 0.13
We therefore investigated the effect of COX inhibition on cholesterol transport proteins in human monocytes/macrophages.
Spec (investigated) Regulation (effect) of Spec (investigated) Negative_regulation (inhibition) of COX in macrophages
13) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.38 Pain Relevance 0.19
We assessed COX-1/COX-2 IC50 values of several COX inhibitors.
Regulation (values) of Negative_regulation (inhibitors) of COX
14) Confidence 0.09 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.09 Pain Relevance 0.16
We therefore examined the effect of non-selective and selective COX-1 inhibitors on 27-hydroxylase and ABCA1 expression.


Spec (examined) Regulation (effect) of Spec (examined) Negative_regulation (inhibitors) of COX
15) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0
In contrast with the changes associated with NO, COX inhibitors do not affect fetal vessel basal perfusion pressure nor potentiate the effects of the thromboxane mimetic.
Neg (nor) Regulation (affect) of Negative_regulation (inhibitors) of COX
16) Confidence 0.06 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.10 Pain Relevance 0
Since microglial COX-2 expression and PGE(2) synthesis are increased in human and experimental prion diseases, we investigated the effects of the NSAIDs indomethacin and BF389, an experimental COX-2 selective inhibitor, on the PrP105-132-induced microglial IL-6 and TNF-alpha synthesis in vitro.
Spec (investigated) Regulation (effects) of Negative_regulation (inhibitor) of COX associated with creutzfeldt jakob disease and cinod
17) Confidence 0.05 Published 2002 Journal Brain Res. Section Abstract Doc Link 11792368 Disease Relevance 0.45 Pain Relevance 0.53
In order to determine if some of the anti-proliferative effects of piroxicam were due to its role as COX inhibitor, COX-2 protein levels in MSTO and NCI cells were assessed by western blot.
Regulation (role) of Negative_regulation (inhibitor) of COX
18) Confidence 0.04 Published 2008 Journal J Transl Med Section Body Doc Link PMC2412853 Disease Relevance 0.33 Pain Relevance 0
We therefore investigated the effect of COX inhibition on cholesterol transport proteins in human monocytes/macrophages.
Spec (investigated) Regulation (effect) of in monocytes Spec (investigated) Negative_regulation (inhibition) of COX in macrophages
19) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.38 Pain Relevance 0.19
involved in the inflammatory response, the ability of NSAIDs to inhibit COX-2
Regulation (involved) of Negative_regulation (inhibit) of COX associated with inflammatory response and cinod
20) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 1.57 Pain Relevance 0.96

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