INT77429

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Context Info
Confidence 0.34
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.09
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
blood 2
spinal 2
colon 2
kidney 2
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 103 100.00 Very High Very High Very High
COX-2 inhibitor 25 100.00 Very High Very High Very High
Hyperalgesia 13 100.00 Very High Very High Very High
cINOD 84 99.96 Very High Very High Very High
analgesia 14 99.20 Very High Very High Very High
Pain 106 97.48 Very High Very High Very High
cytokine 15 96.08 Very High Very High Very High
Peripheral nerve injury 3 95.56 Very High Very High Very High
Spinal cord 9 91.32 High High
Glutamate 7 91.12 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 142 100.00 Very High Very High Very High
Hyperalgesia 15 100.00 Very High Very High Very High
Hyperplasia 2 99.96 Very High Very High Very High
Toxicity 23 99.44 Very High Very High Very High
Hemorrhage 10 99.24 Very High Very High Very High
Apoptosis 14 99.08 Very High Very High Very High
Pain 139 97.48 Very High Very High Very High
Pancreatic Cancer 1 97.36 Very High Very High Very High
Nervous System Injury 13 95.56 Very High Very High Very High
Disease 77 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NSAIDs produce both analgesia and toxic adverse effects primarily by inhibiting cyclooxygenase (COX), thereby decreasing the production of prostaglandins that signal inflammation and pain as well as mediate physiologic functions such as platelet aggregation, gastric protection, and electrolyte balance in the kidney.
Negative_regulation (decreasing) of Negative_regulation (inhibiting) of COX in kidney associated with pain, inflammation, cinod and analgesia
1) Confidence 0.34 Published 2005 Journal J. Vet. Intern. Med. Section Abstract Doc Link 16231707 Disease Relevance 0.58 Pain Relevance 0.95
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity, thereby suppressing the synthesis of proinflammatory prostaglandins.
Negative_regulation (suppressing) of Negative_regulation (inhibit) of COX associated with inflammation and cinod
2) Confidence 0.21 Published 1999 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 10093892 Disease Relevance 0.42 Pain Relevance 0.66
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) can block renin release via inhibition of cyclooxygenase (COX).
Negative_regulation (block) of Negative_regulation (inhibition) of COX associated with inflammation and cinod
3) Confidence 0.15 Published 1998 Journal J. Investig. Med. Section Abstract Doc Link 9737091 Disease Relevance 0.10 Pain Relevance 0.20
In vitro experimental studies find that COX-2 inhibitors decrease cellular proliferation, increase apoptosis, and modulate genes involved in cell cycle regulation.
Negative_regulation (decrease) of Negative_regulation (inhibitors) of COX associated with cox-2 inhibitor, apoptosis and hyperplasia
4) Confidence 0.14 Published 2003 Journal Clin Prostate Cancer Section Abstract Doc Link 15040874 Disease Relevance 1.12 Pain Relevance 0.34
combination of LOX and COX specific inhibitors has been described in colon and
Negative_regulation (combination) of Negative_regulation (inhibitors) of COX in colon
5) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2652614 Disease Relevance 0.64 Pain Relevance 0.03
Biochemical biomarkers of COX inhibition
Negative_regulation (biomarkers) of Negative_regulation (inhibition) of COX
6) Confidence 0.12 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.18 Pain Relevance 0.20
The bleeding risk of NSAIDs lessens following the reduced inhibition of COX-1.
Negative_regulation (reduced) of Negative_regulation (inhibition) of COX associated with cinod and hemorrhage
7) Confidence 0.10 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.42 Pain Relevance 0.32
In keeping with this, several non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce inflammatory hyperalgesia via inhibition of spinal COX activity [58].
Negative_regulation (reduce) of Negative_regulation (inhibition) of COX in spinal associated with hyperalgesia, inflammation and cinod
8) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 0.83 Pain Relevance 1.45
However, these drugs exhibit gastrointestinal toxicity mainly because of a marked decrease in COX-1 activity [4] and renal and blood pressure toxicities mainly because of a decrease in COX-2 activity.
Negative_regulation (decrease) of Negative_regulation (decrease) of COX in blood associated with toxicity
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879362 Disease Relevance 0.80 Pain Relevance 0.49

General Comments

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