INT7743

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Context Info
Confidence 0.47
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 7.75
Pain Relevance 7.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hrh2) signal transducer activity (Hrh2)
Anatomy Link Frequency
liver 1
muscle 1
parietal cell 1
Hrh2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 56 100.00 Very High Very High Very High
alcohol 28 100.00 Very High Very High Very High
cINOD 9 100.00 Very High Very High Very High
Antihistamine 2 100.00 Very High Very High Very High
antidepressant 1 100.00 Very High Very High Very High
Central nervous system 5 99.12 Very High Very High Very High
Clonidine 3 98.30 Very High Very High Very High
Pain 1 98.24 Very High Very High Very High
antiarrhythmic agent 2 97.56 Very High Very High Very High
lidocaine 5 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 100.00 Very High Very High Very High
Adverse Drug Reaction 2 99.90 Very High Very High Very High
Anaemia 6 99.76 Very High Very High Very High
Pressure And Volume Under Development 2 98.44 Very High Very High Very High
Pain 1 98.24 Very High Very High Very High
Dizziness 1 98.00 Very High Very High Very High
Syndrome 1 96.88 Very High Very High Very High
Duodenal Ulcer 6 96.76 Very High Very High Very High
Vomiting 3 96.76 Very High Very High Very High
Gastrointestinal Disease 2 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
H2 receptor antagonist-hepatotoxicant interactions were evaluated in male Fischer-344 rats.
H2 receptor Binding (interactions) of associated with antagonist
1) Confidence 0.47 Published 1984 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6147001 Disease Relevance 0.13 Pain Relevance 0.22
Cimetidine, a commonly used H2-receptor antagonist, was found to interact adversely with many drugs, including class I antiarrhythmics such as lidocaine and quinidine.
H2-receptor Binding (interact) of associated with antagonist and lidocaine
2) Confidence 0.43 Published 1985 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 4006366 Disease Relevance 0 Pain Relevance 0.41
Cimetidine and ranitidine are commonly used H2-receptor antagonists, which interact adversely with many drugs, e.g. inhibition of the metabolism of Class I antiarrhythmics such as lidocaine and quinidine by cimetidine.
H2-receptor Binding (interact) of associated with antagonist and lidocaine
3) Confidence 0.43 Published 1989 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 2737230 Disease Relevance 0 Pain Relevance 0.37
Published pharmacokinetic studies investigating possible interaction between H2-receptor antagonists (n = 22) or prostaglandin analogues (n = 6) and nonsteroidal anti-inflammatory drugs (NSAIDs) have been reviewed.
H2-receptor Binding (interaction) of associated with inflammation, antagonist and cinod
4) Confidence 0.42 Published 1991 Journal Rheumatol. Int. Section Abstract Doc Link 1678204 Disease Relevance 0.25 Pain Relevance 0.49
Numerous classes of prescription medications can interact with alcohol, including antibiotics, antidepressants, antihistamines, barbiturates, benzodiazepines, histamine H2 receptor antagonists, muscle relaxants, nonnarcotic pain medications and anti-inflammatory agents, opioids, and warfarin.
histamine H2 receptor Binding (interact) of in muscle associated with pain, antidepressant, inflammation, antagonist, antihistamine, opioid and alcohol
5) Confidence 0.37 Published 1999 Journal Alcohol Res Health Section Abstract Doc Link 10890797 Disease Relevance 0.29 Pain Relevance 0.81
Adverse reactions and interactions with H2-receptor antagonists.
H2-receptor Binding (interactions) of associated with adverse drug reaction and antagonist
6) Confidence 0.35 Published 1986 Journal Med Toxicol Section Title Doc Link 2878343 Disease Relevance 0.52 Pain Relevance 0.33
The only role for pirenzepine presently is as a second drug with the H2 receptor antagonists in the treatment of acid hypersecretion in the Zollinger-Ellison syndrome.
H2 receptor Binding (drug) of associated with syndrome and antagonist
7) Confidence 0.34 Published 1985 Journal Surg Annu Section Abstract Doc Link 3883541 Disease Relevance 1.16 Pain Relevance 0.23
Cimetidine, a commonly used H2 receptor antagonist, was found to adversely interact with many drugs metabolized by the liver, including class I antiarrhythmic agents, lidocaine and quinidine.
H2 receptor Binding (interact) of in liver associated with antiarrhythmic agent, antagonist and lidocaine
8) Confidence 0.33 Published 1985 Journal Am. Heart J. Section Abstract Doc Link 3890504 Disease Relevance 0.29 Pain Relevance 0.55
Interactions between non-steroidal anti-inflammatory drugs and H2-receptor antagonists or prostaglandin analogues.
H2-receptor Binding (Interactions) of associated with inflammation, antagonist and cinod
9) Confidence 0.32 Published 1991 Journal Rheumatol. Int. Section Title Doc Link 1678204 Disease Relevance 0.28 Pain Relevance 0.54
Treatment and prevention consists of slowing the infusion rate, steroids, and type 1 and 2 histamine receptor antagonists.
2 histamine receptor Binding (slowing) of associated with antagonist
10) Confidence 0.31 Published 2008 Journal Curr Allergy Asthma Rep Section Abstract Doc Link 18377776 Disease Relevance 1.91 Pain Relevance 0.19
Animals were pretreated with saline, a combination of the H1 and H2 receptor antagonists diphenhydramine (20 mg/kg) and cimetidine (80 mg/kg), or individual doses of diphenhydramine or cimetidine.
H2 receptor Binding (combination) of associated with antagonist
11) Confidence 0.28 Published 1985 Journal Circ. Shock Section Abstract Doc Link 2414028 Disease Relevance 0.22 Pain Relevance 0.27
Iron protein succynilate in the treatment of iron deficiency: potential interaction with H2-receptor antagonists.
H2-receptor Binding (interaction) of associated with anaemia and antagonist
12) Confidence 0.27 Published 1993 Journal Int J Clin Pharmacol Ther Toxicol Section Title Doc Link 8100220 Disease Relevance 0.73 Pain Relevance 0.15
These include competitive antagonists that interact with stimulatory receptors (e.g., histamine H2-receptor antagonists) as well as noncompetitive inhibitors of H+K(+)-ATPase (e.g., omeprazole).
H2-receptor Binding (interact) of associated with antagonist
13) Confidence 0.20 Published 1992 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 1355465 Disease Relevance 0.24 Pain Relevance 0.37
H2-receptor antagonists bind competitively to receptors on the basal parietal cell membrane.
H2-receptor Binding (bind) of in parietal cell associated with antagonist
14) Confidence 0.16 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2688149 Disease Relevance 0.31 Pain Relevance 0.09
Because the H2-receptor antagonists elevate gastric pH, bind to and inhibit the hepatic cytochrome P-450 enzyme system, and undergo renal tubular secretion, competition with other drugs sharing these pathways has resulted in a number of drug interactions, most of which are not clinically significant.
H2-receptor Binding (bind) of associated with antagonist
15) Confidence 0.09 Published 1987 Journal Pharmacotherapy Section Abstract Doc Link 2895455 Disease Relevance 0.36 Pain Relevance 0.36
Clinically important adverse effects and drug interactions with H2-receptor antagonists: an update.
H2-receptor Binding (interactions) of associated with antagonist
16) Confidence 0.09 Published 1987 Journal Pharmacotherapy Section Title Doc Link 2895455 Disease Relevance 0.35 Pain Relevance 0.35
The present results seem to indicate that the antagonistic effect of metiamide against either guanfacine or clonidine is probably due to its alpha-adrenoceptor blocking action rather than its histamine H2-receptor blocking action, suggesting that these interactions might be of central origin.
H2-receptor Binding (action) of associated with clonidine
17) Confidence 0.07 Published 1985 Journal Jpn Heart J Section Abstract Doc Link 2865383 Disease Relevance 0.16 Pain Relevance 0.52
The role of gastric alcohol dehydrogenase in the first-pass metabolism of alcohol is reviewed in this article and the arguments for and against any potential interaction between alcohol and H2 receptor antagonists are also discussed.
H2 receptor Binding (interaction) of associated with antagonist and alcohol
18) Confidence 0.02 Published 1997 Journal Clin Pharmacokinet Section Abstract Doc Link 9260032 Disease Relevance 0.12 Pain Relevance 0.72
A premedication with histamine H1 and H2 receptor antagonists was developed which in five controlled clinical trials blocked histamine-release responses of all grades of severity.
H2 receptor Binding (premedication) of associated with antagonist
19) Confidence 0.02 Published 1985 Journal N Engl Reg Allergy Proc Section Abstract Doc Link 2442588 Disease Relevance 0.44 Pain Relevance 0.12

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