INT77433

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2010
Negated 12
Speculated 9
Reported most in Body
Documents 49
Total Number 62
Disease Relevance 35.07
Pain Relevance 16.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 30
sciatic nerve 9
leukocyte 8
lung 6
muscle 4
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 29 100.00 Very High Very High Very High
Ultiva 14 100.00 Very High Very High Very High
tetrodotoxin 4 100.00 Very High Very High Very High
Spinal cord 393 99.98 Very High Very High Very High
Sciatic nerve 553 99.84 Very High Very High Very High
agonist 142 99.82 Very High Very High Very High
Neuropathic pain 175 99.52 Very High Very High Very High
dorsal root ganglion 45 99.32 Very High Very High Very High
Analgesic 42 99.32 Very High Very High Very High
Inflammation 645 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 948 100.00 Very High Very High Very High
Diabetes Mellitus 463 100.00 Very High Very High Very High
Injury 282 100.00 Very High Very High Very High
Sepsis 140 100.00 Very High Very High Very High
Alzheimer's Dementia 16 100.00 Very High Very High Very High
Nervous System Injury 306 99.98 Very High Very High Very High
Neuropathic Pain 414 99.52 Very High Very High Very High
Edema 8 99.52 Very High Very High Very High
Sciatic Neuropathy 7 99.40 Very High Very High Very High
Disease 159 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effects of lidocaine on NO production and the expression of inducible NO synthase (iNOS) protein and messenger RNA (mRNA) in activated macrophages.
Spec (examined) Regulation (effects) of Gene_expression (expression) of inducible NO synthase in macrophages associated with lidocaine
1) Confidence 0.62 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133614 Disease Relevance 0.48 Pain Relevance 0.30
Indeed, sciatic nerve ligation did not alter the NOS2 expression in the spinal cord of WT mice, but significantly increased their expression in NOS1-KO mice, when comparing sham-operated vs. sciatic nerve-injured animals (one way ANOVA, p<0.021).
Neg (not) Regulation (alter) of in sciatic nerve Gene_expression (expression) of NOS2 in spinal cord associated with targeted disruption, sciatic nerve and spinal cord
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.60 Pain Relevance 0.58
The possible alterations in NOS2 and NOS3 expression induced by neuropathic pain have been also evaluated in this study.
Spec (possible) Regulation (alterations) of Gene_expression (expression) of NOS2 associated with neuropathic pain
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.86 Pain Relevance 0.76
Clonidine exerts its action on iNOS expression through increasing enzyme induction instead of enzyme stability.


Regulation (action) of Gene_expression (expression) of iNOS
4) Confidence 0.52 Published 2008 Journal J. Surg. Res. Section Body Doc Link 18262561 Disease Relevance 0 Pain Relevance 0
Although CHOP (an apoptosis-associated gene correlated with the UPR) expression is elevated in response to erstressin treatment in A172 cells, the effects on iNOS expression levels or activity are not a consequence of reduced viability or programmed cell death induced by the compound.
Regulation (effects) of Gene_expression (expression) of iNOS in A172 associated with apoptosis
5) Confidence 0.51 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.30 Pain Relevance 0
Suppressive effects of TEE on the production of NO and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated macrophages were also assessed.
Regulation (effects) of Gene_expression (production) of iNOS in macrophages
6) Confidence 0.46 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 17949929 Disease Relevance 0.30 Pain Relevance 0.08
We examined the effects of lidocaine on NO production and the expression of inducible NO synthase (iNOS) protein and messenger RNA (mRNA) in activated macrophages.
Spec (examined) Regulation (effects) of Gene_expression (expression) of iNOS in macrophages associated with lidocaine
7) Confidence 0.45 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11133614 Disease Relevance 0.48 Pain Relevance 0.30
The aqueous extract of corni fructus exerts anti-inflammatory and analgesic effects by suppressing COX-2 and iNOS expression through the down-regulation of NF-kappaB binding activity.
Regulation (regulation) of Gene_expression (expression) of iNOS associated with inflammation and analgesic
8) Confidence 0.43 Published 2009 Journal J Med Food Section Abstract Doc Link 19735178 Disease Relevance 0.29 Pain Relevance 0.52
The effects of TTX on iNOS, CAT-2, and GTPCH expression were comparable to those of lidocaine.
Regulation (effects) of Gene_expression (expression) of iNOS associated with tetrodotoxin and lidocaine
9) Confidence 0.43 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717319 Disease Relevance 0 Pain Relevance 1.17
This study is to explore the effect of remifentanil on inducible nitric oxide synthase (iNOS) expression, IL-6 and IL-10 levels, myeloperoxidase (MPO) activity, white blood cell count in bronchoalveolar (BALF), ALT and AST activity in septic mice.
Regulation (effect) of Gene_expression (expression) of iNOS in white blood cell associated with urological neuroanatomy and ultiva
10) Confidence 0.43 Published 2010 Journal Mol. Biol. Rep. Section Abstract Doc Link 19757155 Disease Relevance 0.16 Pain Relevance 0.33
Our results demonstrate that in contrast to WT mice, the spinal cord expression of NOS1 in NOS2-KO animals was not altered by sciatic nerve injury.
Neg (not) Regulation (altered) of Gene_expression (expression) of NOS2 in sciatic nerve associated with targeted disruption, nervous system injury, sciatic nerve and spinal cord
11) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.39 Pain Relevance 0.90
Our results also show, for first time, that the expression of NOS2 is up-regulated in the spinal cord of NOS1-KO mice during chronic sciatic nerve injury-induced neuropathic pain.
Regulation (regulated) of Gene_expression (expression) of NOS2 in spinal cord associated with targeted disruption, nervous system injury, neuropathic pain, sciatic nerve and spinal cord
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.61 Pain Relevance 1.00
Our results did not show significant changes in the expression of NOS2 and NOS3, mRNA and protein, on day 21th after sciatic nerve injury.
Neg (not) Regulation (changes) of Gene_expression (expression) of NOS2 in sciatic nerve associated with nervous system injury and sciatic nerve
13) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.86 Pain Relevance 0.75
Effect of GW0742 treatment on NO formation and iNOS expression
Regulation (Effect) of Gene_expression (expression) of iNOS
14) Confidence 0.41 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.51 Pain Relevance 0.08
In addition, the expression of inducible nitric oxide synthase (iNOS) was measured in activated SCs by flow cytometry.
Regulation (measured) of Gene_expression (expression) of inducible nitric oxide synthase in SCs
15) Confidence 0.41 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20035831 Disease Relevance 1.02 Pain Relevance 0.89
In addition, the expression of inducible nitric oxide synthase (iNOS) was measured in activated SCs by flow cytometry.
Regulation (measured) of Gene_expression (expression) of iNOS in SCs
16) Confidence 0.41 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20035831 Disease Relevance 1.02 Pain Relevance 0.89
It is the early phase of tumor formation that is most affected in the absence of iNOS, consistent with recent data linking iNOS expression with transcriptional upregulation of signal transducers and activators of transcription 3 (STAT3) by nuclear epidermal growth factor receptor (EGFR) (Lo et al. 2005).
Regulation (linking) of Gene_expression (expression) of iNOS associated with cancer
17) Confidence 0.39 Published 2007 Journal Transgenic Res Section Body Doc Link PMC1829418 Disease Relevance 0.83 Pain Relevance 0
Selective iNOS inhibition with 1400W and induction of sepsis in iNOS-deficient mice both showed reduced vascular permeability without decreasing leukocyte adhesion. 1400W produced less attenuation of vascular leakage, probably because iNOS production was not entirely abrogated, although nonspecific effects of this inhibitor cannot be excluded.
Regulation (Selective) of Gene_expression (inhibition) of iNOS in leukocyte associated with adhesions and sepsis
18) Confidence 0.39 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 0.83 Pain Relevance 0.03
Selective iNOS inhibition with 1400W and induction of sepsis in iNOS-deficient mice both showed reduced vascular permeability without decreasing leukocyte adhesion. 1400W produced less attenuation of vascular leakage, probably because iNOS production was not entirely abrogated, although nonspecific effects of this inhibitor cannot be excluded.
Regulation (Selective) of Gene_expression (inhibition) of iNOS in leukocyte associated with adhesions and sepsis
19) Confidence 0.39 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 0.78 Pain Relevance 0
On day 7, the iNOS expression was assessed by Western blot and localized by immuno-histochemistry in cryostat sections.
Regulation (assessed) of Gene_expression (expression) of iNOS
20) Confidence 0.39 Published 1998 Journal Int. J. Radiat. Biol. Section Body Doc Link 9737539 Disease Relevance 0.08 Pain Relevance 0

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