INT77434

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2011
Negated 11
Speculated 1
Reported most in Body
Documents 151
Total Number 154
Disease Relevance 96.76
Pain Relevance 38.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 28
brain 18
muscle 15
lung 14
liver 11
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1689 100.00 Very High Very High Very High
cytokine 1182 100.00 Very High Very High Very High
Spinal cord 392 100.00 Very High Very High Very High
agonist 263 100.00 Very High Very High Very High
chemokine 154 100.00 Very High Very High Very High
Inflammatory mediators 142 100.00 Very High Very High Very High
Clonidine 24 99.98 Very High Very High Very High
Neuropathic pain 255 99.84 Very High Very High Very High
Inflammatory response 188 99.76 Very High Very High Very High
Sciatic nerve 267 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2061 100.00 Very High Very High Very High
Targeted Disruption 833 100.00 Very High Very High Very High
Sepsis 275 100.00 Very High Very High Very High
Adhesions 247 100.00 Very High Very High Very High
Urological Neuroanatomy 89 100.00 Very High Very High Very High
Diabetes Mellitus 251 99.98 Very High Very High Very High
Nervous System Injury 390 99.88 Very High Very High Very High
Neuropathic Pain 462 99.84 Very High Very High Very High
Drug Induced Neurotoxicity 43 99.84 Very High Very High Very High
Influenza Virus Infection 140 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhanced iNOS expression and NO production lead to enhanced antioxidant gene expression in oxidative myofibers, providing protection against oxidative stress (Fig. 6).
Neg (NO) Positive_regulation (Enhanced) of Gene_expression (expression) of iNOS associated with stress
1) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0.61 Pain Relevance 0
The virus inoculation induced NOS2 expression in the lumbar dorsal horn of mice with herpetic allodynia, but not postherpetic allodynia.
Positive_regulation (induced) of Gene_expression (expression) of NOS2 in dorsal horn associated with allodynia, dorsal horn and herpes simplex virus infection
2) Confidence 0.68 Published 2007 Journal Neuroscience Section Abstract Doc Link 17997045 Disease Relevance 1.30 Pain Relevance 0.75
CONCLUSIONS: NF-kappaB is involved in the clonidine-induced enhancement of iNOS expression in endotoxin-activated macrophages.
Positive_regulation (enhancement) of Gene_expression (expression) of iNOS in macrophages
3) Confidence 0.67 Published 2008 Journal J. Surg. Res. Section Body Doc Link 18262561 Disease Relevance 0 Pain Relevance 0
We sought to elucidate which of these enzymes is involved in the clonidine-induced enhancement of iNOS expression.
Positive_regulation (enhancement) of Gene_expression (expression) of iNOS associated with clonidine
4) Confidence 0.67 Published 2008 Journal J. Surg. Res. Section Abstract Doc Link 18262561 Disease Relevance 0.37 Pain Relevance 0.44
Clonidine-induced enhancement of iNOS expression involves NF-kappaB.
Positive_regulation (induced) of Gene_expression (expression) of iNOS associated with clonidine
5) Confidence 0.67 Published 2008 Journal J. Surg. Res. Section Title Doc Link 18262561 Disease Relevance 0.46 Pain Relevance 0.49
Compared with sham group, iNOS protein expression, white blood cell count in BALF, ALT and AST activity, MPO activity, IL-6 and IL-10 levels were markedly increased in CLP group.
Positive_regulation (increased) of Gene_expression (expression) of iNOS protein in white blood cell associated with urological neuroanatomy
6) Confidence 0.66 Published 2010 Journal Mol. Biol. Rep. Section Abstract Doc Link 19757155 Disease Relevance 0.62 Pain Relevance 0.59
APAP injection markedly augmented intrahepatic gene expression of inducible nitric oxide synthase (iNOS) and heme oxygenase (HO)-1.
Positive_regulation (augmented) of Gene_expression (expression) of iNOS associated with paracetamol
7) Confidence 0.65 Published 2006 Journal Eur. J. Immunol. Section Abstract Doc Link 16552707 Disease Relevance 0.56 Pain Relevance 0.76
The possible alterations in NOS2 and NOS3 expression induced by neuropathic pain have been also evaluated in this study.
Positive_regulation (induced) of Gene_expression (expression) of NOS2 associated with neuropathic pain
8) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.86 Pain Relevance 0.76
Human clinical studies have associated increased iNOS expression with poor prognosis in breast cancer patients (Loibl et al. 2005), and the use of non-steroidal anti-inflammatory drugs (NSAIDs) with a 22–39% reduction in the risk of breast cancer (Harris et al. 2005; Khuder and Mutgi 2001).
Positive_regulation (increased) of Gene_expression (expression) of iNOS associated with inflammation, breast cancer and cinod
9) Confidence 0.61 Published 2007 Journal Transgenic Res Section Body Doc Link PMC1829418 Disease Relevance 0.94 Pain Relevance 0.22
(R+)-alpha-lipoic acid) and Gingko biloba extract EGb 761, but not phosphodiesterase inhibitors such as propentophylline, prevent the up-regulation of AGE-induced iNOS expression and NO production.
Neg (NO) Positive_regulation (induced) of Gene_expression (expression) of iNOS
10) Confidence 0.61 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860491 Disease Relevance 0.47 Pain Relevance 0.19
(R+)-alpha-lipoic acid) and Gingko biloba extract EGb 761, but not phosphodiesterase inhibitors such as propentophylline, prevent the up-regulation of AGE-induced iNOS expression and NO production.
Positive_regulation (up-regulation) of Gene_expression (expression) of iNOS
11) Confidence 0.61 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860491 Disease Relevance 0.47 Pain Relevance 0.19
It is worth noticing that NO donor was sufficient both in vitro and in vivo to induce iNOS expression (Fig. 4C and 4D and Fig. 5C and 5D), suggesting that both culture muscle cells and skeletal muscles have intact machineries to induce iNOS expression; the difference may be that oxidative muscle, but not glycolytic muscle, has the ability to trigger the initial increase in NO production.
Positive_regulation (induce) of Gene_expression (expression) of iNOS in muscle
12) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0.20 Pain Relevance 0.03
Endotoxin induces greater NO production and iNOS expression in mouse oxidative soleus muscle than in glycolytic white vastus lateralis muscle
Positive_regulation (induces) of Gene_expression (expression) of iNOS in muscle
13) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0.51 Pain Relevance 0.03
Clonidine, a widely used anti-hypertension agent and an effective adjunct to anesthesia/sedation and pain management, has been shown to enhance iNOS expression, but the mechanisms underlying its action remain unstudied.
Positive_regulation (enhance) of Gene_expression (expression) of iNOS associated with anesthesia, hypertension, pain management and sleep disorders
14) Confidence 0.59 Published 2008 Journal J. Surg. Res. Section Abstract Doc Link 18262561 Disease Relevance 0.48 Pain Relevance 0.47
RESULTS: Clonidine significantly enhanced LPS-induced iNOS expression.
Positive_regulation (-) of Gene_expression (expression) of iNOS
15) Confidence 0.59 Published 2008 Journal J. Surg. Res. Section Body Doc Link 18262561 Disease Relevance 0 Pain Relevance 0
RESULTS: Clonidine significantly enhanced LPS-induced iNOS expression.
Positive_regulation (enhanced) of Gene_expression (expression) of iNOS
16) Confidence 0.59 Published 2008 Journal J. Surg. Res. Section Body Doc Link 18262561 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Analgesic effects of TFR may be related to promoting the release of NO and increasing expression the of iNOS as well as inhibiting the production of PGE2.


Positive_regulation (increasing) of Gene_expression (expression) of iNOS
17) Confidence 0.58 Published 2007 Journal Zhong Yao Cai Section Body Doc Link 17571769 Disease Relevance 0 Pain Relevance 0
The aqueous extract of Harpagophytum procumbens was shown to suppress PGE(2) synthesis and nitric oxide production by inhibiting lipopolysaccharide-stimulated enhancement of the cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) mRNAs expressions in L929 cells.
Positive_regulation (enhancement) of Gene_expression (expressions) of iNOS in L929
18) Confidence 0.58 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646256 Disease Relevance 0.24 Pain Relevance 0.30
However, an increase of iNOS gene expression was found in spinal cords of eNOS and nNOS deficient mice.
Positive_regulation (increase) of Gene_expression (expression) of iNOS in spinal cords
19) Confidence 0.58 Published 2007 Journal Eur J Pain Section Abstract Doc Link 17395508 Disease Relevance 0.80 Pain Relevance 0.71
Our study has demonstrated that the NWS virus can induce NOS-2 expression in the infected mouse brain, especially in the olfactory bulb and hippocampus.
Positive_regulation (induce) of Gene_expression (expression) of NOS-2 in olfactory bulb associated with hippocampus
20) Confidence 0.57 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 0.85 Pain Relevance 0.11

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