INT77435

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2011
Negated 11
Speculated 10
Reported most in Abstract
Documents 343
Total Number 353
Disease Relevance 208.49
Pain Relevance 91.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 32
liver 17
neuronal 17
microglial cell 8
RAW 264 6
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3178 100.00 Very High Very High Very High
cytokine 2017 100.00 Very High Very High Very High
Paracetamol 353 100.00 Very High Very High Very High
Inflammatory response 346 100.00 Very High Very High Very High
Spinal cord 341 100.00 Very High Very High Very High
ischemia 238 100.00 Very High Very High Very High
Inflammatory mediators 175 100.00 Very High Very High Very High
COX2 119 100.00 Very High Very High Very High
electroacupuncture 6 100.00 Very High Very High Very High
IPN 97 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3762 100.00 Very High Very High Very High
Targeted Disruption 1804 100.00 Very High Very High Very High
Apoptosis 963 100.00 Very High Very High Very High
Injury 865 100.00 Very High Very High Very High
Cv Unclassified Under Development 202 100.00 Very High Very High Very High
Adenoma 16 100.00 Very High Very High Very High
Repression 29 99.92 Very High Very High Very High
Adhesions 460 99.90 Very High Very High Very High
Inflammatory Pain 100 99.90 Very High Very High Very High
Infection 3179 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, it suppressed induction of inducible nitric oxide synthase (iNOS) in the activated macrophages.
Positive_regulation (induction) of inducible nitric oxide synthase in macrophages
1) Confidence 0.70 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18164565 Disease Relevance 0.45 Pain Relevance 0.11
Additionally, it suppressed induction of inducible nitric oxide synthase (iNOS) in the activated macrophages.
Positive_regulation (induction) of iNOS in macrophages
2) Confidence 0.70 Published 2008 Journal J Ethnopharmacol Section Abstract Doc Link 18164565 Disease Relevance 0.45 Pain Relevance 0.11
Treatment of macrophages with SBT leaf extract also caused a significant inhibition of iNOS activation.
Positive_regulation (activation) of iNOS in leaf
3) Confidence 0.70 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16332512 Disease Relevance 0.42 Pain Relevance 0.29
We show in this study that AGEs increase nitric oxide production by induction of the inducible nitric oxide synthase (iNOS) on the mRNA and protein level in the murine microglial cell line N-11.
Positive_regulation (induction) of iNOS in microglial cell
4) Confidence 0.69 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860491 Disease Relevance 0.46 Pain Relevance 0.07
Anti-inflammatory activity of SC was evaluated using acetic acid-induced vascular permeability, carrageenan-induced air pouch formation and analyses of nitrite content and induced nitric oxide synthase (iNOS) level in the macrophage cells.
Positive_regulation (induced) of iNOS in macrophage
5) Confidence 0.69 Published 2008 Journal J Ethnopharmacol Section Body Doc Link 18790036 Disease Relevance 0.25 Pain Relevance 0
Although previous studies have suggested that nitric oxide (NO) plays a role in the neurotoxicity of MMA, the involvement of NO-induced nitrosative damage from inducible nitric oxide synthase (iNOS) in MMA-induced seizures are poorly understood.
Positive_regulation (inducible) of iNOS in MMA associated with convulsion and drug induced neurotoxicity
6) Confidence 0.68 Published 2009 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 19073247 Disease Relevance 0.48 Pain Relevance 0.13
Nitric oxide (NO) is a reactive nitrogen radical produced by activated Kupffer cells via the induction of inducible nitric oxide synthase (iNOS).
Positive_regulation (induction) of iNOS in Kupffer cells
7) Confidence 0.67 Published 2002 Journal Toxicology Section Abstract Doc Link 12049838 Disease Relevance 0.41 Pain Relevance 0.09
Nitric oxide (NO) is a reactive nitrogen radical produced by activated Kupffer cells via the induction of inducible nitric oxide synthase (iNOS).
Positive_regulation (inducible) of iNOS in Kupffer cells
8) Confidence 0.67 Published 2002 Journal Toxicology Section Abstract Doc Link 12049838 Disease Relevance 0.41 Pain Relevance 0.09
The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro.
Positive_regulation (inducible) of iNOS associated with analgesic, cinod and cox1
9) Confidence 0.67 Published 1999 Journal Inflamm. Res. Section Title Doc Link 10450786 Disease Relevance 0.10 Pain Relevance 0.44
From the immune system, macrophages play a central role in managing many different immunopathological phenomena such as the overproduction of pro-inflammatory cytokines and inflammatory mediators (reactive oxygen species (ROS), nitric oxide (NO) and prostaglandin E2) generated by activated inducible nitric oxide synthase (iNOS) and cyclooxygenase [15].
Positive_regulation (activated) of inducible nitric oxide synthase in immune system associated with inflammatory mediators, inflammation and cytokine
10) Confidence 0.67 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127228 Disease Relevance 0.71 Pain Relevance 0.36
In previous studies using N-methyl-D-aspartate (NMDA)-mediated excitotoxicity, a model for hypoxic-ischemic injury to the postnatal brain [14,15], we have shown an upregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) [16] and increased levels of the oxidative marker nitrotyrosine [17].
Positive_regulation (upregulation) of inducible nitric oxide synthase in brain associated with hypoxia and injury
11) Confidence 0.67 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1462999 Disease Relevance 0.98 Pain Relevance 0.04
BACKGROUND: Up-regulation of inducible nitric oxide synthase (iNOS) plays a crucial role in initiating systemic inflammatory response during sepsis.
Positive_regulation (inducible) of iNOS associated with inflammatory response, sepsis and clonidine
12) Confidence 0.67 Published 2008 Journal J. Surg. Res. Section Abstract Doc Link 18262561 Disease Relevance 0.46 Pain Relevance 0.40
In a dose-dependent manner, lidocaine significantly attenuated the LPS-induced upregulation of iNOS and CAT-2.
Positive_regulation (upregulation) of iNOS associated with lidocaine
13) Confidence 0.66 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717319 Disease Relevance 0 Pain Relevance 1.15
In accordance to our findings, DeAlba et al. [4] also demonstrated that the spinal cord protein levels of NOS2 did not change at 26 days after total sciatic nerve ligation, although an increase in the protein levels of NOS2 has been also demonstrated in the spinal cord of WT mice at 7 or 14 days after nerve injury [8].
Positive_regulation (increase) of NOS2 in nerve associated with nervous system injury, sciatic nerve and spinal cord
14) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.97 Pain Relevance 0.76
These observations suggest that the inhibition of net NO production by SBT leaf extract may be due to its scavenging activity and/or its inhibitory effects on iNOS activation.
Positive_regulation (activation) of iNOS in leaf
15) Confidence 0.61 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16332512 Disease Relevance 0.38 Pain Relevance 0.28
In the lung, however, endotoxin-induced iNOS is derived largely from infiltrating leukocytes [30].
Positive_regulation (induced) of iNOS in leukocytes
16) Confidence 0.61 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 1.09 Pain Relevance 0.08
Activation of the cytokine-inducible nitric oxide synthase isoform (iNOS), with consequent over-production of NO, has been well documented in both animal models of sepsis and in septic patients, and leads to vasodilation and pressor refractoriness [3-6].
Positive_regulation (Activation) of iNOS associated with increased venous pressure under development, sepsis and cytokine
17) Confidence 0.61 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 1.58 Pain Relevance 0.28
Activation of the cytokine-inducible nitric oxide synthase isoform (iNOS), with consequent over-production of NO, has been well documented in both animal models of sepsis and in septic patients, and leads to vasodilation and pressor refractoriness [3-6].
Positive_regulation (Activation) of cytokine-inducible nitric oxide synthase isoform associated with increased venous pressure under development, sepsis and cytokine
18) Confidence 0.61 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 1.57 Pain Relevance 0.28
Nonetheless, the consistency of the findings with two different methods of attenuating iNOS production bolsters the evidence for the relevance of iNOS induction to vascular leakage.
Positive_regulation (induction) of iNOS
19) Confidence 0.61 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 0.68 Pain Relevance 0.08
We show in this study that AGEs increase nitric oxide production by induction of the inducible nitric oxide synthase (iNOS) on the mRNA and protein level in the murine microglial cell line N-11.
Positive_regulation (induction) of inducible nitric oxide synthase in microglial cell
20) Confidence 0.61 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860491 Disease Relevance 0.46 Pain Relevance 0.07

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