INT77490

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Context Info
Confidence 0.68
First Reported 1998
Last Reported 2011
Negated 7
Speculated 3
Reported most in Body
Documents 85
Total Number 88
Disease Relevance 43.54
Pain Relevance 9.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
chest 5
muscles 4
blood 3
coronary artery 2
extracellular matrix 2
Tnnc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 411 100.00 Very High Very High Very High
anesthesia 26 100.00 Very High Very High Very High
chemokine 6 100.00 Very High Very High Very High
Pain 10 99.92 Very High Very High Very High
imagery 30 99.20 Very High Very High Very High
Ultiva 8 99.04 Very High Very High Very High
cva 25 98.74 Very High Very High Very High
Angina 189 98.68 Very High Very High Very High
Inflammatory response 84 97.52 Very High Very High Very High
cytokine 92 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 445 100.00 Very High Very High Very High
Myocardial Infarction 239 100.00 Very High Very High Very High
Coronary Artery Disease 56 99.96 Very High Very High Very High
Pain 12 99.92 Very High Very High Very High
Systemic Inflammatory Response Syndrome 884 99.90 Very High Very High Very High
Pyometra 884 99.90 Very High Very High Very High
Age-related Macular Degeneration 3 99.52 Very High Very High Very High
Renal Failure 1 99.28 Very High Very High Very High
Dyspnea 3 99.16 Very High Very High Very High
Multiple Myeloma 3 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been demonstrated that perioperative elevations of cTnI concentrations were associated with major cardiac complications up to 1 year after surgery [12].
Positive_regulation (elevations) of cTnI
1) Confidence 0.68 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 1.30 Pain Relevance 0.28
A possible cause for the increased cTnI concentrations could be the presence of endotoxins into the circulation.
Positive_regulation (increased) of cTnI
2) Confidence 0.68 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.63 Pain Relevance 0.06
However, we could not find an association between a diagnosis of SIRS and increased cTnI concentrations.
Positive_regulation (increased) of cTnI associated with systemic inflammatory response syndrome
3) Confidence 0.68 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 1.14 Pain Relevance 0.12
Chest pain after PTCA was accompanied with consecutive elevation of cTnI in 40%, while in absence of chest pain cTnI was elevated only in 8% of patients.
Positive_regulation (elevation) of cTnI in chest
4) Confidence 0.66 Published 2004 Journal Vnitr Lek Section Body Doc Link 15125370 Disease Relevance 0 Pain Relevance 0
Borderline increase of troponin I (cTnI) is associated with higher rates of cardiovascular events compared with normal levels in the setting of acute coronary syndrome (ACS), but the significance of borderline cTnI levels in patients without chest pain may differ.
Spec (may) Positive_regulation (increase) of cTnI in chest associated with acute coronary syndrome and angina
5) Confidence 0.63 Published 2008 Journal Am. J. Cardiol. Section Abstract Doc Link 18721503 Disease Relevance 0.57 Pain Relevance 0.09
Eighteen (39%) of the pyometra dogs had increased postoperative cTnI concentrations (range 0.3–6.4 ?
Positive_regulation (increased) of cTnI associated with pyometra
6) Confidence 0.59 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.59 Pain Relevance 0
Of the 46 dogs with pyometra, 13 (28%) had increased preoperative cTnI concentrations (range 0.3–13.2 ?
Positive_regulation (increased) of cTnI associated with pyometra
7) Confidence 0.59 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.63 Pain Relevance 0
Chest pain after PTCA was accompanied with consecutive elevation of cTnI in 40%, while in absence of chest pain cTnI was elevated only in 8% of patients.
Positive_regulation (elevated) of cTnI in chest
8) Confidence 0.57 Published 2004 Journal Vnitr Lek Section Body Doc Link 15125370 Disease Relevance 0 Pain Relevance 0
Although alternative causes for mildly increased cTnI concentrations are possible [21], it is likely that the degree of increase of cTnI concentration in serum provides an estimate of the extent of myocardial damage in our dogs.
Positive_regulation (increased) of cTnI
9) Confidence 0.49 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.28 Pain Relevance 0
However, in 5 of the dogs with increased cTnI-concentrations the preoperative creatinine concentration was not known.
Positive_regulation (increased) of cTnI
10) Confidence 0.49 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.27 Pain Relevance 0
Further studies are needed to investigate whether increased concentrations of cTnI are associated with a higher risk of perioperative complications.


Spec (whether) Positive_regulation (concentrations) of cTnI
11) Confidence 0.49 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.46 Pain Relevance 0.07
Although alternative causes for mildly increased cTnI concentrations are possible [21], it is likely that the degree of increase of cTnI concentration in serum provides an estimate of the extent of myocardial damage in our dogs.
Positive_regulation (increase) of cTnI
12) Confidence 0.49 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.29 Pain Relevance 0
Two of the healthy control dogs in our study (which all had undetectable concentrations of cTnI preoperatively) had increased concentrations of cTnI after surgery.
Positive_regulation (concentrations) of cTnI
13) Confidence 0.49 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.71 Pain Relevance 0.11
Of the 13 dogs with increased preoperative cTnI concentrations, 8 had lower, 4 had increased, and one had unchanged cTnI concentrations after surgery.
Positive_regulation (increased) of cTnI
14) Confidence 0.49 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.53 Pain Relevance 0
g/l) before surgery and 18 (39%) had increased cTnI-concentrations the day after surgery.
Positive_regulation (increased) of cTnI
15) Confidence 0.49 Published 2008 Journal Acta Vet Scand Section Abstract Doc Link PMC2546406 Disease Relevance 0.88 Pain Relevance 0.14
In total, 20 out of 46 dogs (43%) with pyometra had increased concentrations of cTnI at some time during the study, which indicates that increased cTnI concentrations are common during the perioperative period in dogs with pyometra.
Positive_regulation (increased) of cTnI associated with pyometra
16) Confidence 0.45 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.77 Pain Relevance 0
Ongoing myocyte damage because of SIRS or inflammation induced by systemically released endotoxin could also contribute to elevated concentrations of cTnI postsurgically.
Positive_regulation (elevated) of cTnI in myocyte associated with inflammation and systemic inflammatory response syndrome
17) Confidence 0.45 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.73 Pain Relevance 0.09
Thirteen (28%) of the dogs had increased cTnI concentrations (> 0.2 ?
Positive_regulation (increased) of cTnI
18) Confidence 0.45 Published 2008 Journal Acta Vet Scand Section Abstract Doc Link PMC2546406 Disease Relevance 1.01 Pain Relevance 0.17
None of the studied clinical variables (including SIRS) were found to reliably predict increased preoperative cTnI concentrations.
Positive_regulation (increased) of cTnI associated with systemic inflammatory response syndrome
19) Confidence 0.45 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.65 Pain Relevance 0.09
Mild to moderate increases in cTnI appears to be common in dogs with pyometra before and after surgery, but the clinical importance of this finding is uncertain.
Positive_regulation (increases) of cTnI associated with pyometra
20) Confidence 0.45 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.84 Pain Relevance 0.12

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