INT77515

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 3.67
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC3) transport (ASIC3) plasma membrane (ASIC3)
cytoplasm (ASIC3)
Anatomy Link Frequency
intestine 2
sensory neuron 1
pore 1
ASIC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 43 100.00 Very High Very High Very High
Inflammation 38 100.00 Very High Very High Very High
Calcitonin gene-related peptide 5 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
Kinase C 8 99.76 Very High Very High Very High
Pain 103 99.26 Very High Very High Very High
ischemia 3 99.12 Very High Very High Very High
bradykinin 6 98.40 Very High Very High Very High
addiction 2 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 3 99.12 Very High Very High Very High
Pain 133 98.08 Very High Very High Very High
Ganglion Cysts 16 94.80 High High
Acidosis 14 94.20 High High
Lactic Acidosis 1 94.04 High High
INFLAMMATION 44 93.60 High High
Neuropathic Pain 20 93.36 High High
Injury 14 92.96 High High
Nociception 12 92.52 High High
Hyperalgesia 11 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased acid-sensing ion channel ASIC-3 in inflamed human intestine.
Positive_regulation (Increased) of ASIC-3 in intestine associated with inflammation and asic
1) Confidence 0.67 Published 2001 Journal Eur J Gastroenterol Hepatol Section Title Doc Link 11507351 Disease Relevance 0.38 Pain Relevance 0.43
We report that H(+) opens ASIC3 by speeding release of Ca(2+) from a high-affinity binding site (K(Ca) = 150 nM) on the extracellular side of the pore.
Positive_regulation (opens) of ASIC3 in pore
2) Confidence 0.50 Published 2003 Journal Neuron Section Abstract Doc Link 12526774 Disease Relevance 0.29 Pain Relevance 0.34
While rASIC3 (rDRASIC) requires very acidic pH (pH < 4.5) for activation of the sustained current, the non-inactivating hASIC3 current starts to be activated when the pH decreases to below pH 6. hASIC3 is an acid sensor and might play an important role in the detection of lasting pH changes in human.
Positive_regulation (activated) of hASIC3
3) Confidence 0.50 Published 1998 Journal FEBS Lett. Section Abstract Doc Link 9744806 Disease Relevance 0.15 Pain Relevance 0.11
RESULTS: In the Western blot, there was a significant three-fold increase in the mean relative optical density of the ASIC-3 55-kDa band (but not ASIC-1 or ASIC-2) in full-thickness inflamed intestine, as well as in separated muscle and mucosal layers.
Positive_regulation (increase) of ASIC-3 in intestine
4) Confidence 0.45 Published 2001 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 11507351 Disease Relevance 0.17 Pain Relevance 0
Perhaps more importantly, we show that the plateau current of ASIC3 can be dramatically increased (10-30-fold) by association with NHERF-1, leading to a significant sustained current at pH 6.6.
Positive_regulation (increased) of ASIC3
5) Confidence 0.38 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16234233 Disease Relevance 0.26 Pain Relevance 0.42
Co-expression of CIPP and ASIC3 in COS cells increases the maximal ASIC3 peak current density by a factor of 5 and slightly shifts the pH(0.5) for activation from pH 6.2 to pH 6.4.
Positive_regulation (increases) of ASIC3
6) Confidence 0.28 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11872753 Disease Relevance 0.48 Pain Relevance 0.31
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Positive_regulation (sensing) of ASIC3 associated with pain
7) Confidence 0.25 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 19339181 Disease Relevance 0 Pain Relevance 0.19
This interaction requires the C-terminal region of ASIC3 and the fourth PDZ domain of CIPP.
Positive_regulation (requires) of ASIC3
8) Confidence 0.23 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11872753 Disease Relevance 0.48 Pain Relevance 0.33
The increase of ASIC3/ASIC2b current is accompanied by a shift in its pH dependence toward more physiological pH values and may lead to an increase of sensory neuron excitability.
Positive_regulation (increase) of ASIC3 in sensory neuron associated with addiction
9) Confidence 0.15 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14976185 Disease Relevance 0.24 Pain Relevance 0.56
Thus, NGF acts via TrkA and p75 to activate a number of other kinase pathways, for example, that of p38 kinase, leading to altered gene transcription and increased synthesis of sensory neuropeptides (substance P, CGRP), ion channels (TRPV1, NaV1.8, ASIC3) [141-143], membrane receptors such as bradykinin and P2X3 [144,145], and structural molecules, including neurofilament and channel anchoring proteins such as the annexin light chain p11 [121].
Positive_regulation (increased) of ASIC3 associated with nerve growth factor, neuropeptide, bradykinin, calcitonin gene-related peptide and substance p
10) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.02 Pain Relevance 1.00
While PSD-95 decreased surface ASIC3 and ASIC3-mediated currents, Lin-7b increased surface ASIC3 and ASIC3-mediated current.
Positive_regulation (increased) of ASIC3
11) Confidence 0.12 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.11
While PSD-95 decreased surface ASIC3 and ASIC3-mediated currents, Lin-7b increased surface ASIC3 and ASIC3-mediated current.
Positive_regulation (increased) of ASIC3-mediated
12) Confidence 0.12 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.11
This paper shows that Zn(2+) potentiates the acid activation of homomeric and heteromeric ASIC2a-containing channels (i.e.
Positive_regulation (activation) of ASIC3
13) Confidence 0.09 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11457851 Disease Relevance 0.18 Pain Relevance 0.27

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