INT77523

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Context Info
Confidence 0.63
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 13.81
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ADC) mitochondrion (ADC) small molecule metabolic process (ADC)
lyase activity (ADC) cellular nitrogen compound metabolic process (ADC)
Anatomy Link Frequency
blood 2
macrophages 1
neocortex 1
brain 1
cortex 1
ADC (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 215 99.60 Very High Very High Very High
amygdala 29 98.96 Very High Very High Very High
Hippocampus 28 92.88 High High
Clonidine 4 92.12 High High
imagery 251 92.00 High High
ischemia 52 89.88 High High
Inflammation 49 83.92 Quite High
tolerance 15 81.80 Quite High
intrathecal 40 74.48 Quite High
Inflammatory stimuli 4 70.96 Quite High
Disease Link Frequency Relevance Heat
Infection 177 100.00 Very High Very High Very High
Viral Meningitis 69 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 465 99.54 Very High Very High Very High
Opportunistic Infections 35 99.44 Very High Very High Very High
Ketoacidosis 242 99.40 Very High Very High Very High
Uterine Fibroids 12 98.64 Very High Very High Very High
Sarcoma 5 98.24 Very High Very High Very High
Pressure And Volume Under Development 152 96.96 Very High Very High Very High
Stroke 40 96.12 Very High Very High Very High
Neurologic Manifestations 20 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Isoproterenol, yohimbine and theophylline, which activate AdC, caused the conformational changes of HSA similar to basic transitions.
Positive_regulation (activate) of AdC
1) Confidence 0.63 Published 1998 Journal J. Biomol. Struct. Dyn. Section Abstract Doc Link 9745899 Disease Relevance 0 Pain Relevance 0.16
Isoproterenol, yohimbine diphenhydramine, chlorpromazine and atropine, which activate AdC and hinder Ca-PPI, cause conformational changes of HSA similar to basic transitions.
Positive_regulation (activate) of AdC
2) Confidence 0.61 Published 1998 Journal Spectrochim Acta A Mol Biomol Spectrosc Section Abstract Doc Link 9807240 Disease Relevance 0 Pain Relevance 0.15
The mean ADC (in × 10?
Positive_regulation (mean) of ADC
3) Confidence 0.32 Published 2008 Journal Eur Radiol Section Body Doc Link PMC2516183 Disease Relevance 1.80 Pain Relevance 0.05
One speculation is that to some extent neopterin is produced in the meningeal and perivascular spaces in relation to local infection, but that in ADC and its underlying substrate, HIVE, the character of infection and its capacity to produce neopterin changes as infected and uninfected macrophages and microglia are activated.
Positive_regulation (activated) of ADC in macrophages associated with viral meningitis and infection
4) Confidence 0.21 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 1.29 Pain Relevance 0.12
The changes in blood neopterin (Figure 2B) showed a similar increase with falling CD4+ T cells, and overall correlated with the CSF neopterin (p < 0.0001, Spearman r = 0.567), though the levels were lower in the blood, particularly in the ADC groups.
Positive_regulation (lower) of ADC in blood
5) Confidence 0.21 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.70 Pain Relevance 0.07
While CSF neopterin has been known to be elevated in HIV infection and further increased in ADC/HIVE and CNS opportunistic infections for more than two decades [4,5], most studies characterizing the concentrations of this pteridine have focused on small groups or compared only restricted subject groups.


Positive_regulation (increased) of ADC associated with opportunistic infections, acquired immune deficiency syndrome or hiv infection, central nervous system, viral meningitis and infection
6) Confidence 0.19 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 1.11 Pain Relevance 0.18
However, the effects measured in the amygdala are consistent and in contrast with the trends for increased ADC values found in the remaining brain tissue.
Positive_regulation (increased) of ADC in brain associated with amygdala
7) Confidence 0.16 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1702559 Disease Relevance 0.65 Pain Relevance 0.21
The advent of antiretroviral therapy (HAART) in western countries has led to significant reduction in the incidence of ADC.[15]
Positive_regulation (incidence) of ADC
8) Confidence 0.15 Published 2005 Journal J Int AIDS Soc Section Body Doc Link PMC2740789 Disease Relevance 2.32 Pain Relevance 0.06
A previous study also observed a gradual increase in ADC toward baseline in the first 2 hours after HI (9).
Positive_regulation (increase) of ADC
9) Confidence 0.07 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.26 Pain Relevance 0.17
One speculation is that to some extent neopterin is produced in the meningeal and perivascular spaces in relation to local infection, but that in ADC and its underlying substrate, HIVE, the character of infection and its capacity to produce neopterin changes as infected and uninfected macrophages and microglia are activated.
Positive_regulation (activated) of ADC in microglia associated with viral meningitis and infection
10) Confidence 0.07 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 1.29 Pain Relevance 0.12
This was correlated with a significant increase in ADC and T2w signal values and Gd-DOTA extravasation at D30 after exposure.
Positive_regulation (increase) of ADC
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815784 Disease Relevance 0.37 Pain Relevance 0.04
These changes were correlated with a significant increase in ADC and T2w values (Fig. 2H–I).
Positive_regulation (increase) of ADC
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815784 Disease Relevance 0 Pain Relevance 0
Gd-DOTA extravasation and increased ADC and T2W shown by MRI suggested an increase in blood brain barrier (BBB) permeability.
Positive_regulation (increased) of ADC in blood
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815784 Disease Relevance 0.07 Pain Relevance 0
Cortical ADC values in the parecoxib group were markedly less increased on Day 8 (p < 0.01).
Positive_regulation (increased) of ADC
14) Confidence 0.03 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1764728 Disease Relevance 0.21 Pain Relevance 0.15
The post-ischemic ADC increase in the neocortex due to "pseudonormalization" was consistently and significantly lower in parecoxib-treated than in the saline-treated animals.
Positive_regulation (increase) of ADC in neocortex
15) Confidence 0.03 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764728 Disease Relevance 0.59 Pain Relevance 0.16
The present finding that bumetanide increases cerebral ADC values in the DKA rats is consistent with the hypothesis that in DKA, cell swelling is diminished by inhibition of Na-K-Cl cotransport.
Positive_regulation (increases) of ADC associated with pressure and volume under development and ketoacidosis
16) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2551666 Disease Relevance 1.56 Pain Relevance 0.18
When bumetanide was added to saline/insulin infusion, greater increases in CBF were observed in the striatum and there was a trend toward greater ADC increase in the cortex.
Positive_regulation (increase) of ADC in cortex
17) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2551666 Disease Relevance 1.57 Pain Relevance 0

General Comments

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