INT77538

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Context Info
Confidence 0.55
First Reported 1998
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 2
Total Number 23
Disease Relevance 10.24
Pain Relevance 1.55

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protein binding, bridging (Cnn3)
Anatomy Link Frequency
vessels 4
mesangial cells 3
smooth muscle 2
kidney 2
myometrium 1
Cnn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 22 92.56 High High
fibrosis 132 88.92 High High
Dismenorea 1 70.96 Quite High
anesthesia 88 45.72 Quite Low
alcohol 22 23.20 Low Low
Disease Link Frequency Relevance Heat
Renal Disease 330 99.36 Very High Very High Very High
Chronic Renal Failure 44 98.96 Very High Very High Very High
Renal Cancer 44 98.24 Very High Very High Very High
Disease 22 97.28 Very High Very High Very High
Injury 88 97.04 Very High Very High Very High
Fibrosis 154 88.92 High High
Disease Progression 44 88.00 High High
Sclerosis 66 84.88 Quite High
Internal Fibrosis 22 80.52 Quite High
Keloid Scars 22 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myofibroblasts are usually immunostained using several specific markers, such as alpha-smooth muscle actin (ASMA), vimentin, and calponin in several tissues (Frangogiannis et al., 2000; Chen et al., 2009; Ferguson et al., 2009) However, to the authors' knowledge there has been no report of calponin expression in renal myofibroblasts, while calponin expression in the renal vessels, mesangial cells, and renal tumor cells has been reported (Islam et al., 2004a & b).
Gene_expression (expression) of calponin in mesangial cells associated with renal cancer
1) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.78 Pain Relevance 0.19
Our previous report detailed calponin expression in the myofibroblasts of human kidneys (Choi et al., 2008).
Gene_expression (expression) of calponin
2) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.53 Pain Relevance 0.04
These findings suggest that calponin may be expressed and play a role at the very final stage of glomerular damage.
Gene_expression (expressed) of calponin
3) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.57 Pain Relevance 0.08
Periglomerular expression of calponin
Gene_expression (expression) of calponin
4) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.16 Pain Relevance 0.04
Myofibroblasts are usually immunostained using several specific markers, such as alpha-smooth muscle actin (ASMA), vimentin, and calponin in several tissues (Frangogiannis et al., 2000; Chen et al., 2009; Ferguson et al., 2009) However, to the authors' knowledge there has been no report of calponin expression in renal myofibroblasts, while calponin expression in the renal vessels, mesangial cells, and renal tumor cells has been reported (Islam et al., 2004a & b).
Gene_expression (expression) of calponin in mesangial cells associated with renal cancer
5) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.77 Pain Relevance 0.19
To our knowledge, the present study is the first report of calponin expression in the myofibroblasts of animal kidneys.
Gene_expression (expression) of calponin
6) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.56 Pain Relevance 0.04
Therefore, we hypothesized that renal myofibroblasts may also express calponin, especially in the periglomerular region, at the very end stage of disease in an experimentally induced animal model of chronic renal failure.
Gene_expression (express) of calponin associated with chronic renal failure and disease
7) Confidence 0.55 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.55 Pain Relevance 0.05
To examine calponin expression and structural changes of periglomerular calponin-positive glomeruli, five serial tissue sections were stained with periodic acid-methenamine silver (PAMS), alpha-smooth muscle actin (ASMA) antiserum, calponin antiserum, vimentin antiserum, and the periodic acid-Schiff (PAS) method.
Spec (examine) Gene_expression (expression) of calponin in smooth muscle
8) Confidence 0.48 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0 Pain Relevance 0
Thus, in this study we aimed to examine calponin expression in two experimental models, puromycin aminonucleoside (PAN) nephropathy and subtotal nephrectomy (SNx), to investigate the role of calponin in chronic renal injury.


Spec (examine) Gene_expression (expression) of calponin associated with injury and renal disease
9) Confidence 0.48 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.59 Pain Relevance 0
Weak calponin-immunostaining was detected in some glomeruli (Fig. 3).


Gene_expression (detected) of calponin
10) Confidence 0.48 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.15 Pain Relevance 0
In conjunction with our previous report, this data represents the first documentation of the expression of calponin in renal myofibroblasts.
Gene_expression (expression) of calponin
11) Confidence 0.43 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998789 Disease Relevance 0.34 Pain Relevance 0
In the present study we examined calponin expression in two chronic nephropathy models, puromycin aminonucleoside (PAN) nephropathy and subtotal nephrectomy (SNx), to investigate the role of calponin in chronic renal injury.
Spec (examined) Gene_expression (expression) of calponin associated with injury and renal disease
12) Confidence 0.43 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998789 Disease Relevance 0.46 Pain Relevance 0
To examine calponin expression and structural changes of periglomerular calponin-positive glomeruli, five serial tissue sections were stained with periodic acid-methenamine silver (PAMS), alpha-smooth muscle actin (ASMA) antiserum, calponin antiserum, vimentin antiserum, and the periodic acid-Schiff (PAS) method.
Spec (examine) Gene_expression (expression) of calponin-positive in smooth muscle
13) Confidence 0.42 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0 Pain Relevance 0
There were no periglomerular calponin-positive cells in the sham, PAN 1 and 2 week, and SNx 1, 2, and 4 week groups (data not shown), despite the presence of calponin-positivity in the renal vessels of the same groups (Fig. 3C).
Gene_expression (presence) of calponin in vessels
14) Confidence 0.42 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.14 Pain Relevance 0.03
There are some reports of calponin-positive and calponin-negative myofibroblasts; however, they only describe that some myofibroblasts within lesions were focally immunostained for calponin suggesting a functional heterogeneity of myofibroblasts (Lazard et al., 1993; Prasad et al., 1999; Barbareschi et al., 2001).
Gene_expression (immunostained) of calponin
15) Confidence 0.42 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.36 Pain Relevance 0.03
H1-calponin is the predominant isoform specifically expressed in differentiated smooth muscle cells as well as other cell types including myofibroblasts in the context of diverse pathological situations (for review, Rozenblum & Gimona, 2008).
Gene_expression (expressed) of calponin in smooth muscle cells
16) Confidence 0.37 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.31 Pain Relevance 0
Expression of calponin in periglomerular myofibroblasts of rat kidney with experimental chronic injuries

Our previous research demonstrated that calponin-immunoreactivity was localized in myofibroblasts of the periglomerular region of human kidney specimens obtained at the time of transplantation from organ recipients.

Gene_expression (Expression) of calponin in kidney associated with injury
17) Confidence 0.37 Published 2010 Journal Anatomy & Cell Biology Section Title Doc Link PMC2998789 Disease Relevance 0.42 Pain Relevance 0
In the present study we tested the hypothesis that renal myofibroblasts in the periglomerular region may express calponin at the very end stage of chronic renal failure in the experimental animal kidney.
Neg (failure) Gene_expression (express) of calponin in kidney associated with chronic renal failure
18) Confidence 0.37 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.25 Pain Relevance 0
Myofibroblasts are usually immunostained using several specific markers, such as alpha-smooth muscle actin (ASMA), vimentin, and calponin in several tissues (Frangogiannis et al., 2000; Chen et al., 2009; Ferguson et al., 2009) However, to the authors' knowledge there has been no report of calponin expression in renal myofibroblasts, while calponin expression in the renal vessels, mesangial cells, and renal tumor cells has been reported (Islam et al., 2004a & b).
Gene_expression (expression) of calponin in vessels associated with renal cancer
19) Confidence 0.19 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.77 Pain Relevance 0.19
Myofibroblasts are usually immunostained using several specific markers, such as alpha-smooth muscle actin (ASMA), vimentin, and calponin in several tissues (Frangogiannis et al., 2000; Chen et al., 2009; Ferguson et al., 2009) However, to the authors' knowledge there has been no report of calponin expression in renal myofibroblasts, while calponin expression in the renal vessels, mesangial cells, and renal tumor cells has been reported (Islam et al., 2004a & b).
Gene_expression (expression) of calponin in vessels associated with renal cancer
20) Confidence 0.19 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.78 Pain Relevance 0.19

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