INT77555

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Context Info
Confidence 0.05
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.82
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cell 3
joint 1
muscle 1
platelet 1
thd (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 69 99.64 Very High Very High Very High
psoriasis 63 99.12 Very High Very High Very High
Arthritis 50 98.76 Very High Very High Very High
cytokine 37 96.16 Very High Very High Very High
Demyelination 6 95.44 Very High Very High Very High
Central nervous system 22 91.68 High High
rheumatoid arthritis 27 90.00 High High
Spinal cord 2 89.36 High High
Multiple sclerosis 14 52.08 Quite High
methotrexate 1 50.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 85 99.64 Very High Very High Very High
Arthritis 56 99.60 Very High Very High Very High
Multiple Sclerosis 60 99.56 Very High Very High Very High
Psoriasis 106 99.12 Very High Very High Very High
Muscular Atrophy 16 98.48 Very High Very High Very High
Syndrome 6 97.36 Very High Very High Very High
Demyelinating Disease 6 95.44 Very High Very High Very High
Disease 73 95.36 Very High Very High Very High
Infection 5 94.12 High High
Congenital Anomalies 11 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with different clinical conditions associated with muscle atrophy exhibit similar increases in mRNAs encoding components of the UPS (e.g. an increase in mRNAs encoding Ub and proteasome subunits) [11, 29–31].
Positive_regulation (increase) of Ub in muscle associated with muscular atrophy
1) Confidence 0.05 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.97 Pain Relevance 0
There are at least a thousand E3 enzymes (Ub ligase), and each can recognize a specific protein substrate and catalyze the transfer of an activated Ub from the E2 carrier protein to the substrate protein [10, 15].
Positive_regulation (activated) of Ub
2) Confidence 0.05 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0 Pain Relevance 0
Functions of Ub not associated with proteolysis Ub can also be conjugated to proteins as a monomer (rather than as the typical Ub chain).
Positive_regulation (conjugated) of Ub
3) Confidence 0.03 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.60 Pain Relevance 0
Specifically, the tagged protein will be recognized by the 26S proteasome, a very large multicatalytic protease complex that not only recognizes Ub-conjugated proteins but also removes Ub, unwinds the protein, and injects it into the central core of the 26S proteasome.
Positive_regulation (removes) of Ub
4) Confidence 0.03 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.28 Pain Relevance 0
In contrast, platelet-derived growth factor (PDGF, 20 ng/ml) increased [3H]Thd incorporation similarly in chicks, pullets, and hens.
Positive_regulation (increased) of Thd in platelet
5) Confidence 0.01 Published 1998 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 9748410 Disease Relevance 0.08 Pain Relevance 0
Since previous studies demonstrated that autoreactive T cells, especially TH1 and TH17, are essential to induce EAE, we further analyzed TH cells in EAE-induced mice.
Positive_regulation (essential) of TH17 in T cells associated with multiple sclerosis
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 1.59 Pain Relevance 0.22
Psoriasis is a chronic inflammation characterized by increased Th-1 and Th-17 T cell activity [128].
Positive_regulation (increased) of Th-17 in T cell associated with psoriasis and inflammation
7) Confidence 0.00 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.78 Pain Relevance 0.28
First, it contributes to the accumulation of Th1 and Th17 cells in arthritic joints, and second, it plays an inhibitory role by limiting total numbers of these pathogenic T cell subsets in peripheral lymphoid organs.


Positive_regulation (accumulation) of Th17 in T cell associated with arthritis
8) Confidence 0.00 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 1.11 Pain Relevance 0.23
However, it is also possible that the increased Th1/Th17 responses in the periphery versus the joint after anti-TNF?
Spec (possible) Positive_regulation (increased) of Th17 in joint
9) Confidence 0.00 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 1.33 Pain Relevance 0.33

General Comments

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