INT77583

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.23
Pain Relevance 3.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
DRN 4
spinal cord 2
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 7 100.00 Very High Very High Very High
Spinal cord 1 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
Inflammation 22 99.88 Very High Very High Very High
Eae 8 98.96 Very High Very High Very High
Hyperalgesia 10 98.86 Very High Very High Very High
Raphe 13 95.28 Very High Very High Very High
Pain 7 95.04 Very High Very High Very High
Central grey 5 92.28 High High
midbrain 1 91.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 13 99.88 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 99.64 Very High Very High Very High
Injury 7 98.96 Very High Very High Very High
Hyperalgesia 10 98.86 Very High Very High Very High
Pain 7 95.04 Very High Very High Very High
Stress 6 93.84 High High
Urological Neuroanatomy 7 92.48 High High
Nociception 2 91.68 High High
Anxiety Disorder 3 91.60 High High
Neuropathic Pain 3 85.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, in competition binding experiments at h alpha2A and h5-HT1A receptors expressed in CHO cells, several compounds, including the antagonists 1-(2-pyrimidinyl)piperazine (1-PP), (+/-)-idazoxan, benalfocin (SKF 86466), yohimbine and RX 821,002, displayed preference for h alpha2A versus h5-HT1A receptors of only 1.4-, 3.6-, 4-, 10- and 11-fold, respectively (based on differences in pKi values).
Positive_regulation (preference) of Gene_expression (expressed) of 5-HT1A associated with antagonist
1) Confidence 0.49 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.29
These results suggest that the synthesis of 5-HT1A receptors, including autoreceptors, is increased in the DRN and vlPAG during peripheral inflammation.
Positive_regulation (increased) of Gene_expression (synthesis) of 5-HT1A in DRN associated with inflammation
2) Confidence 0.49 Published 2000 Journal Neuroreport Section Abstract Doc Link 11059903 Disease Relevance 0.47 Pain Relevance 0.35
Following carrageenan inflammation, the expression of 5-HT1A receptor mRNA in the DRN and bilateral vlPAG neurons was significantly increased.
Positive_regulation (increased) of Gene_expression (expression) of 5-HT1A in DRN associated with inflammation
3) Confidence 0.49 Published 2000 Journal Neuroreport Section Abstract Doc Link 11059903 Disease Relevance 0.42 Pain Relevance 0.36
Here we showed that 1 or 4 h after a subcutaneous bee venom challenge, expression of 5-HT1A receptor mRNA in the ipsilateral lumbar spinal cord increased significantly by 80.94 or 37.86%, respectively.
Positive_regulation (increased) of Gene_expression (expression) of 5-HT1A in spinal cord associated with spinal cord
4) Confidence 0.49 Published 2003 Journal Pain Section Abstract Doc Link 14581120 Disease Relevance 0.95 Pain Relevance 0.94
Specifically, we detected increase in the expression of 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C and 5-HT4 receptors.
Positive_regulation (increase) of Gene_expression (expression) of 5-HT1A
5) Confidence 0.49 Published 2005 Journal Neuroscience Section Abstract Doc Link 15730869 Disease Relevance 1.34 Pain Relevance 0.51
Furthermore, as well as thermal and mechanical hyperalgesia, CCI caused serotonergic hyperactivity (as shown by the increase of basal activity of serotonergic neurones, extracellular serotonin levels and expression of 5-HT1A receptor gene).
Positive_regulation (increase) of Gene_expression (expression) of 5-HT1A associated with hyperalgesia, eae, attention deficit hyperactivity disorder and serotonin
6) Confidence 0.49 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 17040473 Disease Relevance 1.05 Pain Relevance 1.27

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