INT77586

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Context Info
Confidence 0.46
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.54
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
motoneurons 2
central nervous system 2
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 5 99.78 Very High Very High Very High
Serotonin 21 99.56 Very High Very High Very High
Central nervous system 1 99.04 Very High Very High Very High
sSRI 34 95.08 Very High Very High Very High
Neurotransmitter 9 94.44 High High
Spinal cord 28 92.64 High High
Hippocampus 3 92.60 High High
Pain 3 90.12 High High
antagonist 10 80.84 Quite High
antidepressant 1 75.36 Quite High
Disease Link Frequency Relevance Heat
Prostate Cancer 12 99.60 Very High Very High Very High
Anxiety Disorder 210 95.20 Very High Very High Very High
Spinal Cord Injury 17 94.88 High High
Disease 4 94.44 High High
Aggression 2 91.12 High High
Pain 3 90.12 High High
Cancer 4 80.80 Quite High
Urological Neuroanatomy 4 78.92 Quite High
Obesity 2 78.32 Quite High
Death 1 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of G-protein coupled receptor associated with prostate cancer
1) Confidence 0.46 Published 2006 Journal Int. J. Cancer Section Title Doc Link 16206286 Disease Relevance 0.71 Pain Relevance 0.14
In Ts65Dn mice, fluoxetine treatment restored the expression of 5-HT1A receptors and BDNF.
Positive_regulation (restored) of Gene_expression (expression) of 5-HT1A associated with fluoxetine
2) Confidence 0.45 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592198 Disease Relevance 0.89 Pain Relevance 0.43
To investigate the potential roles of GPCRs in human normal prostate and prostate cancers, we identified and characterized a novel human G-protein coupled receptor, PSGR2, which is highly overexpressed in human prostate cancers.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of G-protein coupled receptor associated with prostate cancer
3) Confidence 0.29 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16206286 Disease Relevance 0.64 Pain Relevance 0.13
Four weeks after non-integrating-Ngn2-hENPs transplantation, sub-cellular localization of 5HT1A expression was entirely restored to intact pattern since 92.3% of alpha-motoneurons displayed 5HT1A expression at the membrane (Figure 3I, K and L).
Positive_regulation (restored) of Gene_expression (expression) of 5HT1A in motoneurons
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012721 Disease Relevance 0.35 Pain Relevance 0.22
For example, (+/-)-idazoxan was only 3.6-fold selective for h alpha2A versus h5-HT1A but 51-fold selective for r alpha2A versus r5-HT1A receptors.
Positive_regulation (selective) of Gene_expression (selective) of r5-HT1A
5) Confidence 0.06 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9750005 Disease Relevance 0 Pain Relevance 0.33
The 5-HT2C subtype of the serotonin receptor family is a G-protein coupled receptor (GPCR) that is broadly expressed in the brain and is proposed to mediate many of the central nervous system actions of serotonin, including those underlying the therapeutic benefit of SSRI treatment in OCD [15].
Positive_regulation (proposed) of Gene_expression (expressed) of G-protein coupled receptor in central nervous system associated with anxiety disorder, central nervous system, ssri and serotonin
6) Confidence 0.04 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.95 Pain Relevance 0.27

General Comments

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