INT77601

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Context Info
Confidence 0.58
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 2.07
Pain Relevance 6.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OR51B4) signal transducer activity (OR51B4)
Anatomy Link Frequency
CHO 4
chondrocyte 1
sensory neurons 1
SFL 1
arms 1
OR51B4 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 16 100.00 Very High Very High Very High
Neuropeptide 6 99.70 Very High Very High Very High
neuralgia 2 99.70 Very High Very High Very High
cytokine 14 99.62 Very High Very High Very High
metalloproteinase 11 99.04 Very High Very High Very High
Mexiletine 32 98.44 Very High Very High Very High
lidocaine 12 98.36 Very High Very High Very High
adenocard 28 97.92 Very High Very High Very High
addiction 2 97.40 Very High Very High Very High
Pain 2 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 9 100.00 Very High Very High Very High
Pain 2 97.08 Very High Very High Very High
Injury 6 95.00 High High
INFLAMMATION 10 91.76 High High
Skin Cancer 2 89.76 High High
Knee Osteoarthritis 36 81.84 Quite High
Nociception 2 72.56 Quite High
Pseudarthrosis 1 66.52 Quite High
Necrosis 2 65.72 Quite High
Tendinopathy 1 64.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using specific antibodies for immunohistochemistry, we have now detected sodium channel beta1 and beta2 subunits in sensory cell bodies within control human postmortem sensory ganglia (78% of small/medium (< or = 50 microm) and 68% of large (> or = 50 microm) cells); their changes in cervical sensory ganglia after avulsion injury paralleled those described for SNS/PN3 alpha-subunits.
Gene_expression (detected) of beta1 in ganglia associated with injury and sodium channel
1) Confidence 0.58 Published 2001 Journal Neuroreport Section Abstract Doc Link 11234750 Disease Relevance 0.28 Pain Relevance 0.34
Sodium channel beta1 and beta2 subunits parallel SNS/PN3 alpha-subunit changes in injured human sensory neurons.
Gene_expression (parallel) of beta1 in sensory neurons associated with sodium channel
2) Confidence 0.58 Published 2001 Journal Neuroreport Section Title Doc Link 11234750 Disease Relevance 0.24 Pain Relevance 0.58
Lidocaine (10 and 100 microM and 1 mM) tend to reduce basal cAMP level on CHO cells stably expressing cloned human beta1-adrenoceptors, whereas the drug did not reduce the isoprenaline-induced cAMP accumulation on CHO cells stably expressing cloned human beta1-, beta2-, and beta3-adrenoceptors.
Gene_expression (expressing) of beta1 in CHO associated with lidocaine
3) Confidence 0.55 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.73
Mexiletine (5, 50, and 500 microM) reduces basal adenosine 3',5'-cyclic monophosphate (cAMP) level and isoprenaline-induced cAMP accumulation on CHO cells stably expressing cloned human beta1- and beta2-adrenoceptors.
Gene_expression (expressing) of beta1 in CHO associated with adenocard and mexiletine
4) Confidence 0.37 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.68
Lidocaine (10 and 100 microM and 1 mM) tend to reduce basal cAMP level on CHO cells stably expressing cloned human beta1-adrenoceptors, whereas the drug did not reduce the isoprenaline-induced cAMP accumulation on CHO cells stably expressing cloned human beta1-, beta2-, and beta3-adrenoceptors.
Gene_expression (expressing) of beta1 in CHO associated with lidocaine
5) Confidence 0.37 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.73
We characterized the beta-adrenoceptor-blocking property of mexiletine, a class Ib antiarrhythmic drug, on Chinese hamster ovary (CHO) cells stably expressing cloned human beta1-, beta2-, and beta3-adrenoceptors.
Gene_expression (expressing) of beta1 in CHO associated with mexiletine
6) Confidence 0.37 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.27
Excitable cells express multiple alpha subtypes, designated Na(v)1.1-Na(v)1.9, and three beta subunits, designated beta1, beta2 and beta3.
Gene_expression (express) of beta1
7) Confidence 0.23 Published 2002 Journal Neuroscience Section Abstract Doc Link 12220575 Disease Relevance 0 Pain Relevance 0.25
Coexpression of beta1 or beta3 did not affect inactivation time course or the voltage dependence of activation, but shifted the inactivation curve approximately 10 mV negative, and slowed the repriming rate ca. three-fold. beta2 did not affect channel properties, either by itself or in combination with beta1 or beta3.
Gene_expression (Coexpression) of beta1 associated with addiction
8) Confidence 0.16 Published 2002 Journal Neuroscience Section Abstract Doc Link 12220575 Disease Relevance 0.07 Pain Relevance 0.31
To investigate beta1 and beta3 containing integrin-mediated adhesion and subsequent MMP-2/-9 protein and gene expression in human blood-derived monocytes, biofunctional peptides immobilized onto flexible polyethylene glycol (PEG) arms were grafted onto a gelatin-based interpenetrating network (IPN).
Gene_expression (expression) of beta1 in arms associated with ipn and adhesions
9) Confidence 0.07 Published 2007 Journal Biomaterials Section Abstract Doc Link 16979234 Disease Relevance 0.17 Pain Relevance 0.26
Moreover, there was an increase of 44% in bromodeoxyuridine (BrdU)-labeled cells in cultures of SCC-1 that were transfected with siRNAs to karyopherin beta1 or Ran compared with cells transfected with scrambled siRNA.
Gene_expression (karyopherin) of beta1
10) Confidence 0.05 Published 2010 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 20705629 Disease Relevance 0.18 Pain Relevance 0.19
HMVEC expressed a higher level of G protein beta1 isoform than beta4 isoform.
Gene_expression (expressed) of beta1
11) Confidence 0.04 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14530318 Disease Relevance 0.08 Pain Relevance 0.70
Although none of the cytokines tested affected G(beta1) expression, both IL-1 and TNF-alpha significantly up-regulated G(beta4) expression.
Gene_expression (expression) of beta1 associated with cytokine
12) Confidence 0.04 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14530318 Disease Relevance 0.09 Pain Relevance 0.69
On T lymphoblasts and SFL, mostly CD45RO+ cells, the expression of the beta1 activation-dependent epitope detected by HUTS21 MAb was significantly decreased by aceclofenac, diclofenac, and indomethacin.
Gene_expression (expression) of beta1 in T lymphoblasts
13) Confidence 0.03 Published 1998 Journal Arthritis Rheum. Section Body Doc Link 9751102 Disease Relevance 0 Pain Relevance 0
These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [4].
Gene_expression (expressed) of beta1 in chondrocyte
14) Confidence 0.01 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.95 Pain Relevance 0.47
On T lymphoblasts and SFL, mostly CD45RO+ cells, the expression of the beta1 activation-dependent epitope detected by HUTS21 MAb was significantly decreased by aceclofenac, diclofenac, and indomethacin.
Gene_expression (expression) of beta1 in SFL
15) Confidence 0.01 Published 1998 Journal Arthritis Rheum. Section Body Doc Link 9751102 Disease Relevance 0 Pain Relevance 0

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