INT77602

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 8.66
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAM1) aging (VCAM1) cell adhesion (VCAM1)
plasma membrane (VCAM1)
Anatomy Link Frequency
blood vessels 3
endothelial cell 1
leukocytes 1
PBL 1
endothelium 1
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 66 99.76 Very High Very High Very High
Central nervous system 52 97.76 Very High Very High Very High
Inflammation 203 97.72 Very High Very High Very High
substance P 8 97.48 Very High Very High Very High
COX2 1 96.40 Very High Very High Very High
Multiple sclerosis 430 90.20 High High
Neuropeptide 3 89.28 High High
chemokine 16 88.80 High High
Inflammatory response 12 87.76 High High
metalloproteinase 9 87.44 High High
Disease Link Frequency Relevance Heat
Adhesions 86 100.00 Very High Very High Very High
Atherosclerosis 137 99.68 Very High Very High Very High
INFLAMMATION 227 97.72 Very High Very High Very High
Brain Injury 72 96.88 Very High Very High Very High
Stress 23 93.08 High High
Sepsis 5 90.48 High High
Demyelinating Disease 472 90.20 High High
Injury 47 90.08 High High
Systemic Lupus Erythematosus 14 89.80 High High
Thrombosis 27 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Some NSAIDs are able to inhibit the adhesion of PBL to HUVEC under conditions that resemble blood flow by interfering with the conformational change in VLA-4 that increases its affinity for VCAM-1.


VCAM-1 Binding (affinity) of in PBL
1) Confidence 0.41 Published 1998 Journal Arthritis Rheum. Section Body Doc Link 9751102 Disease Relevance 0 Pain Relevance 0
After exposure to SP, DMEC expressed significant levels of both intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which was accompanied by increased binding to leukocytes expressing the appropriate integrin counter receptors for these CAM.
VCAM-1 Binding (binding) of in leukocytes associated with adhesions and substance p
2) Confidence 0.35 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.52 Pain Relevance 0.60
Correspondingly, we found the highest levels of sE-selectin, sICAM and sVCAM in association with poor neurological outcome (i.e., GOS 1-3) in NS resuscitated patients.
sVCAM Binding (association) of
3) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.97 Pain Relevance 0.07
B, a regulator of several genes implicated in atherogenesis, such as genes coding for intracellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) and cytokines. ?
VCAM-1 Binding (coding) of associated with atherosclerosis, adhesions and cytokine
4) Confidence 0.23 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2747395 Disease Relevance 1.67 Pain Relevance 0.29
Once adherent to the endothelial cell, via VCAM-1 binding, leukocytes and monocytes enter the intima by diapedesis between endothelial cells at their junctions.
VCAM-1 Binding (binding) of in endothelial cell
5) Confidence 0.19 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.64 Pain Relevance 0.27
These complexes bind to receptors on the endothelium, triggering an upregulation of adhesion molecules such as E-selectin, intercellular adhesion molecules 1 (ICAM-1) and vascular cell adhesion molecules 1 (VCAM-1).
VCAM-1 Binding (bind) of in endothelium associated with adhesions
6) Confidence 0.16 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847817 Disease Relevance 1.92 Pain Relevance 0.21
7 to bind to their respective endothelial counter-receptors, vascular-cell adhesion molecule-1 (VCAM-1), and mucosal addressin-cell adhesion molecule-1 (MAdCAM-1).
vascular-cell adhesion molecule-1 Binding (bind) of associated with adhesions
7) Confidence 0.10 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721358 Disease Relevance 0.51 Pain Relevance 0.07
Paramount events in the periphery consist of T-cell activation, tethering, rolling, and adhesion, facilitated by integrin expression on activated T cells and interaction with its upregulated ligand vascular cellular adhesion molecule-1 (VCAM-1), expressed on the endothelium of blood vessels of the CNS.
VCAM-1 Binding (interaction) of in blood vessels associated with central nervous system and adhesions
8) Confidence 0.08 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.82 Pain Relevance 0.45
Paramount events in the periphery consist of T-cell activation, tethering, rolling, and adhesion, facilitated by integrin expression on activated T cells and interaction with its upregulated ligand vascular cellular adhesion molecule-1 (VCAM-1), expressed on the endothelium of blood vessels of the CNS.
vascular cellular adhesion molecule-1 Binding (ligand) of in blood vessels associated with central nervous system and adhesions
9) Confidence 0.08 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.81 Pain Relevance 0.45
Paramount events in the periphery consist of T-cell activation, tethering, rolling, and adhesion, facilitated by integrin expression on activated T cells and interaction with its upregulated ligand vascular cellular adhesion molecule-1 (VCAM-1), expressed on the endothelium of blood vessels of the CNS.
VCAM-1 Binding (ligand) of in blood vessels associated with central nervous system and adhesions
10) Confidence 0.08 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.81 Pain Relevance 0.45

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