INT77604

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 6.54
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAM1) aging (VCAM1) cell adhesion (VCAM1)
plasma membrane (VCAM1)
Anatomy Link Frequency
blood vessels 10
leukocytes 2
PBL 2
endothelium 2
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 75 97.76 Very High Very High Very High
substance P 8 97.48 Very High Very High Very High
Multiple sclerosis 700 91.08 High High
Neuropeptide 3 89.28 High High
Inflammation 100 88.40 High High
metalloproteinase 6 87.44 High High
Inflammatory response 7 85.80 High High
qutenza 1 78.56 Quite High
chemokine 10 67.52 Quite High
cytokine 34 67.04 Quite High
Disease Link Frequency Relevance Heat
Adhesions 24 100.00 Very High Very High Very High
Atherosclerosis 17 99.08 Very High Very High Very High
Demyelinating Disease 770 91.08 High High
Systemic Lupus Erythematosus 14 89.80 High High
Thrombosis 2 89.60 High High
INFLAMMATION 114 88.40 High High
Autoimmune Disease 16 73.40 Quite High
Bacterial Infection 5 63.12 Quite High
Cancer 16 62.64 Quite High
Necrosis 6 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After exposure to SP, DMEC expressed significant levels of both intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), which was accompanied by increased binding to leukocytes expressing the appropriate integrin counter receptors for these CAM.
Positive_regulation (increased) of VCAM-1 Binding (binding) of in leukocytes associated with adhesions and substance p
1) Confidence 0.47 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.52 Pain Relevance 0.60
CONCLUSION: Some NSAIDs are able to inhibit the adhesion of PBL to HUVEC under conditions that resemble blood flow by interfering with the conformational change in VLA-4 that increases its affinity for VCAM-1.


Positive_regulation (increases) of VCAM-1 Binding (affinity) of in PBL
2) Confidence 0.39 Published 1998 Journal Arthritis Rheum. Section Body Doc Link 9751102 Disease Relevance 0 Pain Relevance 0
These complexes bind to receptors on the endothelium, triggering an upregulation of adhesion molecules such as E-selectin, intercellular adhesion molecules 1 (ICAM-1) and vascular cell adhesion molecules 1 (VCAM-1).
Positive_regulation (triggering) of VCAM-1 Binding (bind) of in endothelium associated with adhesions
3) Confidence 0.20 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847817 Disease Relevance 1.92 Pain Relevance 0.21
Paramount events in the periphery consist of T-cell activation, tethering, rolling, and adhesion, facilitated by integrin expression on activated T cells and interaction with its upregulated ligand vascular cellular adhesion molecule-1 (VCAM-1), expressed on the endothelium of blood vessels of the CNS.
Positive_regulation (activated) of VCAM-1 Binding (ligand) of in blood vessels associated with central nervous system and adhesions
4) Confidence 0.11 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.83 Pain Relevance 0.45
Paramount events in the periphery consist of T-cell activation, tethering, rolling, and adhesion, facilitated by integrin expression on activated T cells and interaction with its upregulated ligand vascular cellular adhesion molecule-1 (VCAM-1), expressed on the endothelium of blood vessels of the CNS.
Positive_regulation (activated) of vascular cellular adhesion molecule-1 Binding (ligand) of in blood vessels associated with central nervous system and adhesions
5) Confidence 0.11 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.82 Pain Relevance 0.45
Paramount events in the periphery consist of T-cell activation, tethering, rolling, and adhesion, facilitated by integrin expression on activated T cells and interaction with its upregulated ligand vascular cellular adhesion molecule-1 (VCAM-1), expressed on the endothelium of blood vessels of the CNS.
Positive_regulation (activated) of VCAM-1 Binding (interaction) of in blood vessels associated with central nervous system and adhesions
6) Confidence 0.11 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.83 Pain Relevance 0.45
Paramount events in the periphery consist of T-cell activation, tethering, rolling, and adhesion, facilitated by integrin expression on activated T cells and interaction with its upregulated ligand vascular cellular adhesion molecule-1 (VCAM-1), expressed on the endothelium of blood vessels of the CNS.
Positive_regulation (upregulated) of VCAM-1 Binding (ligand) of in blood vessels associated with central nervous system and adhesions
7) Confidence 0.11 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.82 Pain Relevance 0.45
Paramount events in the periphery consist of T-cell activation, tethering, rolling, and adhesion, facilitated by integrin expression on activated T cells and interaction with its upregulated ligand vascular cellular adhesion molecule-1 (VCAM-1), expressed on the endothelium of blood vessels of the CNS.
Positive_regulation (upregulated) of vascular cellular adhesion molecule-1 Binding (ligand) of in blood vessels associated with central nervous system and adhesions
8) Confidence 0.11 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.81 Pain Relevance 0.45

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