INT77615

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.55
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 100.00 Very High Very High Very High
Paracetamol 2 99.84 Very High Very High Very High
aspirin 14 99.60 Very High Very High Very High
cINOD 19 99.36 Very High Very High Very High
diclofenac 2 98.60 Very High Very High Very High
Antinociceptive 3 97.72 Very High Very High Very High
intrathecal 3 92.04 High High
tail-flick 2 89.80 High High
antinociception 4 88.64 High High
dexamethasone 1 88.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 100.00 Very High Very High Very High
Injury 2 97.88 Very High Very High Very High
Cancer 6 97.64 Very High Very High Very High
Parkinson's Disease 3 89.00 High High
Nociception 3 81.00 Quite High
Shock 3 80.80 Quite High
Pain 1 75.00 Quite High
Adenocarcinoma 1 70.16 Quite High
Disease 2 47.24 Quite Low
Targeted Disruption 1 46.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results obtained in this study confirm that NSAIDs possess different abilities to induce inhibition of cyclooxygenase, and they can be indirectly assessed by their different antinociceptive activities, depending on the algesiometric assays that are used.
Positive_regulation (induce) of Negative_regulation (inhibition) of cyclooxygenase associated with cinod and antinociceptive
1) Confidence 0.50 Published 2001 Journal Pain Res Manag Section Abstract Doc Link 11854764 Disease Relevance 0.29 Pain Relevance 1.46
The protective effects of aspirin are unlikely to be related to cyclooxygenase inhibition as paracetamol (100 mg/kg, i.p.), diclofenac (100 mg/kg, i.p.), ibuprofen (20 mg/kg, i.p.) and indomethacin (100 mg/kg, i.p.) were ineffective.
Positive_regulation (related) of Negative_regulation (inhibition) of cyclooxygenase associated with aspirin, paracetamol and diclofenac
2) Confidence 0.23 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9751197 Disease Relevance 0.16 Pain Relevance 0.61
It is likely that an active metabolite of NCX-2216 contributes to the suppression of cyclooxygenase activity.
Positive_regulation (contributes) of Negative_regulation (suppression) of cyclooxygenase
3) Confidence 0.14 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14755007 Disease Relevance 0.17 Pain Relevance 0.18
Cyclooxygenase (COX) inhibitors have antitumorigenic activity and increase the expression of the early growth response gene Egr-1, a tumor suppressor gene and transcription factor.
Positive_regulation (increase) of Negative_regulation (inhibitors) of Cyclooxygenase associated with cancer
4) Confidence 0.11 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.40 Pain Relevance 0.16
Additionally, these studies also suggest that inhibition of interleukin-2 is mediated by a PPARgamma, which is activated by a cyclooxygenase-2 metabolite of anandamide.
Positive_regulation (activated) of Negative_regulation (metabolite) of cyclooxygenase
5) Confidence 0.11 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0 Pain Relevance 0.04
OBJECTIVE: It is well known that nonsteroidal anti-inflammatory drugs (NSAIDs), such as acetylsalicylic acid, ibuprofen, and indomethacin, induce anti-inflammatory effects through inhibition of cyclooxygenase enzyme activity.
Positive_regulation (induce) of Negative_regulation (inhibition) of cyclooxygenase associated with aspirin, inflammation and cinod
6) Confidence 0.07 Published 2006 Journal Exp. Hematol. Section Abstract Doc Link 16569588 Disease Relevance 0.52 Pain Relevance 0.65

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox