INT77620

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 146
Total Number 152
Disease Relevance 72.40
Pain Relevance 16.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
neuroblasts 9
neuronal precursors 7
neural 7
lymphocytes 7
liver 6
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 53 100.00 Very High Very High Very High
Glutamate 289 99.92 Very High Very High Very High
Chronic pancreatitis 36 99.84 Very High Very High Very High
cerebral cortex 697 99.70 Very High Very High Very High
Hippocampus 79 99.28 Very High Very High Very High
Neuritis 6 99.04 Very High Very High Very High
withdrawal 43 98.96 Very High Very High Very High
endometriosis 6 98.96 Very High Very High Very High
Morphine 27 98.82 Very High Very High Very High
antagonist 306 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 6420 100.00 Very High Very High Very High
Death 1625 100.00 Very High Very High Very High
Neurological Disease 77 99.84 Very High Very High Very High
Malignant Neoplastic Disease 51 99.84 Very High Very High Very High
Pancreatitis 36 99.84 Very High Very High Very High
Basal Cell Carcinoma 16 99.84 Very High Very High Very High
Gastritis 24 99.78 Very High Very High Very High
Hypersensitivity 265 99.50 Very High Very High Very High
Injury 518 99.46 Very High Very High Very High
Convulsion 77 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic (5 days) heroin (5-30 mg/kg) and morphine (10-100 mg/kg) were also associated with increased native Fas (76% and 45%) and with different expressions of glycosylated Fas.
Gene_expression (expressions) of Fas associated with morphine
1) Confidence 0.78 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.30 Pain Relevance 1.12
The main results indicate that chronic heroin/morphine treatment and heroin withdrawal are associated with up-regulation of 35 kDa native Fas (and with different expressions of glycosylated Fas), and also with concomitant increases of dynamin in rat brain.
Gene_expression (expressions) of Fas in brain associated with opiate addiction, withdrawal and morphine
2) Confidence 0.78 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.27 Pain Relevance 1.15
The expression of Fas and FasL peaked at 12 and 20 weeks.
Gene_expression (expression) of Fas
3) Confidence 0.75 Published 2007 Journal Pancreatology Section Body Doc Link 17449963 Disease Relevance 0.07 Pain Relevance 0
However, in the TJ-10-treated rats, the rate of pancreatic acinar cell destruction, the apoptotic index at 12-20 weeks, and the expression of Fas and FasL at 12 and 20 weeks decreased significantly compared to those in untreated rats.
Gene_expression (expression) of Fas in acinar cell
4) Confidence 0.75 Published 2007 Journal Pancreatology Section Body Doc Link 17449963 Disease Relevance 0.06 Pain Relevance 0
An apoptotic index in acinar cells correlated to the expression of Fas and FasL mRNA.
Gene_expression (expression) of Fas in acinar cells
5) Confidence 0.75 Published 2007 Journal Pancreatology Section Body Doc Link 17449963 Disease Relevance 0.07 Pain Relevance 0
Pancreas was histopathologically examined every 4 weeks, and the expression of apoptosis-related factors such as Fas and Fas ligand (FasL) mRNA and protein was analyzed with RT-PCR, in situ hybridization and immunohistochemistry.
Spec (examined) Gene_expression (expression) of Fas in Pancreas
6) Confidence 0.75 Published 2007 Journal Pancreatology Section Body Doc Link 17449963 Disease Relevance 0.09 Pain Relevance 0
Pancreas was histopathologically examined every 4 weeks, and the expression of apoptosis-related factors such as Fas and Fas ligand (FasL) mRNA and protein was analyzed with RT-PCR, in situ hybridization and immunohistochemistry.
Spec (examined) Gene_expression (expression) of Fas in Pancreas
7) Confidence 0.75 Published 2007 Journal Pancreatology Section Body Doc Link 17449963 Disease Relevance 0.09 Pain Relevance 0
ISH and IHC confirmed that Fas and FasL are expressed in the cytoplasm of acinar cells, ductal cells, and lymphocytes.
Gene_expression (expressed) of Fas in lymphocytes
8) Confidence 0.74 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.65 Pain Relevance 0.25
The aim of this study was to examine the expression of the Fas/FasL system and to analyze its correlation with apoptosis in a spontaneous chronic pancreatitis model (the WBN/Kob rat).
Spec (examine) Gene_expression (expression) of Fas associated with apoptosis and chronic pancreatitis
9) Confidence 0.74 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.71 Pain Relevance 0.24
These results suggest that the expression of the Fas/FasL system is involved in acinar cell apoptosis and the onset and progression of chronic pancreatitis in the WBN/Kob rat.
Gene_expression (expression) of Fas in acinar cell associated with apoptosis and chronic pancreatitis
10) Confidence 0.74 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.79 Pain Relevance 0.24
However, whether Fas and FasL are expressed in chronic pancreatitis is unknown.
Gene_expression (expressed) of Fas associated with chronic pancreatitis
11) Confidence 0.74 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.64 Pain Relevance 0.23
Fas expression on untreated SC showed fluctuating levels, while addition of IFN-gamma and TNF-alpha suppressed Fas expression completely.
Gene_expression (expression) of Fas
12) Confidence 0.70 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.74 Pain Relevance 0.21
To assess the possible involvement of the Fas/FasL system in T-cell apoptosis in the PNS of the rat, we characterized Fas and FasL expression on neonatal rat Schwann cells (SC) in vitro.
Gene_expression (expression) of Fas in Schwann cells associated with apoptosis
13) Confidence 0.70 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.64 Pain Relevance 0.12
Regulation of Fas and FasL expression on rat Schwann cells.
Gene_expression (expression) of Fas in Schwann cells
14) Confidence 0.70 Published 2000 Journal Glia Section Title Doc Link 10797617 Disease Relevance 0.59 Pain Relevance 0.12
These findings are in accord with recently published results showing Fas and FasL expression on malignant human cells, derived from brain tumors and upregulation of FasL on astrocytes after exposure to IFN-gamma and TNF-alpha.
Gene_expression (expression) of Fas in astrocytes associated with malignant neoplastic disease and brain tumor
15) Confidence 0.70 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.74 Pain Relevance 0.22
Fas expression on untreated SC showed fluctuating levels, while addition of IFN-gamma and TNF-alpha suppressed Fas expression completely.
Gene_expression (expression) of Fas
16) Confidence 0.70 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.73 Pain Relevance 0.21
We suggest that Fas/FasL expression on SC may contribute to the elimination of invading autoreactive T cells in the PNS in concert with other immune defense mechanisms.
Gene_expression (expression) of Fas in T cells
17) Confidence 0.70 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.46 Pain Relevance 0.19
The main results indicate that chronic heroin/morphine treatment and heroin withdrawal are associated with up-regulation of 35 kDa native Fas (and with different expressions of glycosylated Fas), and also with concomitant increases of dynamin in rat brain.
Gene_expression (expressions) of Fas in brain associated with opiate addiction, withdrawal and morphine
18) Confidence 0.67 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.27 Pain Relevance 1.16
Chronic (5 days) heroin (5-30 mg/kg) and morphine (10-100 mg/kg) were also associated with increased native Fas (76% and 45%) and with different expressions of glycosylated Fas.
Gene_expression (expressions) of Fas associated with morphine
19) Confidence 0.67 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.30 Pain Relevance 1.09
Furthermore, a known inhibitor of JNK suppressed FAS expression in rat hepatocytes.
Gene_expression (expression) of FAS in hepatocytes
20) Confidence 0.67 Published 2007 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 17463161 Disease Relevance 0.21 Pain Relevance 0.11

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