INT77621

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Context Info
Confidence 0.56
First Reported 1998
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 7.62
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
cerebral cortex 2
extracellular matrix 2
endometrium 2
Schwann cells 2
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 11 100.00 Very High Very High Very High
cerebral cortex 54 99.24 Very High Very High Very High
endometriosis 4 98.96 Very High Very High Very High
cINOD 13 94.04 High High
Inflammation 20 94.00 High High
antagonist 18 91.32 High High
Kinase C 3 88.72 High High
agonist 2 83.36 Quite High
ischemia 30 81.24 Quite High
Hippocampus 6 75.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 468 100.00 Very High Very High Very High
Death 111 100.00 Very High Very High Very High
Hypothermia 138 99.30 Very High Very High Very High
Endometriosis (extended) 4 98.96 Very High Very High Very High
Adhesions 24 95.60 Very High Very High Very High
Suicidal Behaviour 162 94.68 High High
INFLAMMATION 26 94.00 High High
Colon Cancer 6 92.32 High High
Hemorrhagic Shock 18 91.20 High High
Pain 9 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of Fas and FasL expression on rat Schwann cells.
Regulation (Regulation) of Gene_expression (expression) of Fas in Schwann cells
1) Confidence 0.56 Published 2000 Journal Glia Section Title Doc Link 10797617 Disease Relevance 0.59 Pain Relevance 0.12
Among the potential molecular targets by which celecoxib may regulate FAS expression, only c-Jun N-terminal kinase-1 (JNK1) was significantly down-regulated.
Regulation (regulate) of Gene_expression (expression) of FAS
2) Confidence 0.53 Published 2007 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 17463161 Disease Relevance 0.22 Pain Relevance 0.12
We therefore also examined estrogen regulation of cell-surface Fas expression at different stages of cell cycle.
Spec (examined) Regulation (regulation) of Gene_expression (expression) of Fas
3) Confidence 0.35 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.14 Pain Relevance 0
Thus estrogen, and consequently estrogen receptors, may be an important regulator of Fas expression in the developing cerebral cortex.
Regulation (regulator) of Gene_expression (expression) of Fas in cerebral cortex associated with cerebral cortex
4) Confidence 0.35 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.55 Pain Relevance 0.12
Fas expression is dependent on cell-matrix interactions and 'anoikis'
Regulation (dependent) of Gene_expression (expression) of Fas
5) Confidence 0.26 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.65 Pain Relevance 0.07
Developmentally, cell-surface Fas expression is modulated by a variety of competing factors including cell-cycle stage, extracellular matrix interactions, p53 phosphorylation and hormone availability.
Regulation (modulated) of Gene_expression (expression) of Fas in extracellular matrix
6) Confidence 0.16 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.86 Pain Relevance 0.07
Alterations in cell-surface Fas expression may significantly influence cortical development.
Regulation (Alterations) of Gene_expression (expression) of Fas
7) Confidence 0.16 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC395829 Disease Relevance 0.53 Pain Relevance 0.05
We previously observed a similar tamoxifen-independent effect of estrogen on the regulation of p53 itself [37], suggesting that estrogen may regulate cell-surface Fas expression by non-classical mechanisms including transcriptional activation mediated by AP-1 [78] or activation of protein kinase pathways [79,80].
Spec (may) Regulation (regulate) of Gene_expression (expression) of Fas
8) Confidence 0.16 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.33 Pain Relevance 0.05
Hypothermia also suppresses apoptosis by down regulating expression of TNF receptor (TNFR1) [102] and its associated pro-death ligand, apoptosis stimulating fragment (Fas) protein.
Regulation (regulating) of Gene_expression (expression) of Fas associated with hypothermia, apoptosis and death
9) Confidence 0.10 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.91 Pain Relevance 0.21
Effects of the levonorgestrel-releasing intrauterine system on cell proliferation, Fas expression and steroid receptors in endometriosis lesions and normal endometrium.
Regulation (Effects) of Gene_expression (expression) of Fas in endometrium associated with pain and endometriosis
10) Confidence 0.09 Published 2009 Journal Hum. Reprod. Section Title Doc Link 19661125 Disease Relevance 0.19 Pain Relevance 0.32
Changes in the expression of proliferating cell nuclear antigen, Fas, progesterone receptor (PRA) and estrogen receptor alpha (ER-alpha) were analyzed by immunohistochemistry.
Regulation (Changes) of Gene_expression (expression) of Fas
11) Confidence 0.09 Published 2009 Journal Hum. Reprod. Section Body Doc Link 19661125 Disease Relevance 0.17 Pain Relevance 0
However the expression of apoptosis-related genes such as Fas, bcl-2 and bax was not affected by indomethacin.
Neg (not) Regulation (affected) of Gene_expression (expression) of Fas associated with apoptosis
12) Confidence 0.03 Published 1998 Journal Yonsei Med. J. Section Abstract Doc Link 9752793 Disease Relevance 1.46 Pain Relevance 0.95

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