INT77627

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Context Info
Confidence 0.44
First Reported 1998
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 15.09
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
Anatomy Link Frequency
endothelial cells 2
MCF-7 2
MDA-MB-231 2
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 11 100.00 Very High Very High Very High
cINOD 23 94.04 High High
dexamethasone 127 94.00 High High
antagonist 10 88.72 High High
Kinase C 3 88.72 High High
Pain 8 88.16 High High
withdrawal 3 85.32 High High
cytokine 4 84.88 Quite High
addiction 4 81.16 Quite High
Angina 2 53.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 593 100.00 Very High Very High Very High
Death 115 99.44 Very High Very High Very High
Prostate Cancer 6 98.96 Very High Very High Very High
Ovarian Cancer 64 98.36 Very High Very High Very High
Breast Cancer 28 97.32 Very High Very High Very High
Endometriosis (extended) 2 96.28 Very High Very High Very High
Skin Cancer 1 96.20 Very High Very High Very High
Cancer 226 95.56 Very High Very High Very High
Glioblastoma 94 95.32 Very High Very High Very High
Colon Cancer 38 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However the expression of apoptosis-related genes such as Fas, bcl-2 and bax was not affected by indomethacin.
Neg (not) Regulation (affected) of Gene_expression (expression) of bax associated with apoptosis
1) Confidence 0.44 Published 1998 Journal Yonsei Med. J. Section Abstract Doc Link 9752793 Disease Relevance 1.46 Pain Relevance 0.95
Ribonuclease protection assays compared the effects of acetaminophen and E2 on expression of selected genes (c-myc, c-fos, cyclin D1, bcl-2, bax, gadd45, mcl-1, p53, p21(CIP1/WAF1), and bcl-xL) in E2-responsive breast cancer (MCF-7) and endometrial adenocarcinoma (Ishikawa) cells as well as in E2-nonresponsive (MDA-MB-231) breast cancer cells.
Regulation (effects) of Gene_expression (expression) of bax in MDA-MB-231 associated with paracetamol, endometriosis (extended) and breast cancer
2) Confidence 0.44 Published 2002 Journal Toxicol. Sci. Section Abstract Doc Link 11896290 Disease Relevance 0.36 Pain Relevance 0.55
We determined the effects of exercise on bcl-2 family upstream of caspase-3, including caspase-9 and bax: bcl-2 ratio.
Spec (determined) Regulation (effects) of Gene_expression (ratio) of bax
3) Confidence 0.44 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.18 Pain Relevance 0
CONCLUSIONS: Our in vitro and in vivo data indicated that the antitumor effects of aspisol on breast cancer cells was probably mediated by the induction of apoptosis, and it could be linked to the downregulation of the COX-2 or bcl-2 expression and up-regulation of caspase-3 or bax expression.


Regulation (regulation) of Gene_expression (expression) of bax
4) Confidence 0.44 Published 2008 Journal Exp. Oncol. Section Body Doc Link 19112426 Disease Relevance 0 Pain Relevance 0
However, although Bax overproduction in response to 100 ?
Regulation (although) of Gene_expression (overproduction) of Bax
5) Confidence 0.43 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.94 Pain Relevance 0
Compared to CTL cells, a rise in Bax:Bcl-2 ratio (panel D, Fig. 4) in cells exposed to TMZ was influenced more by a change in Bax expression (panel A, Fig. 4) than a change in Bcl-2 expression (panel B, Fig. 4).
Regulation (change) of Gene_expression (expression) of Bax
6) Confidence 0.43 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.32 Pain Relevance 0.20
Our data demonstrate that 3HFD treatment down-regulated Bcl-2 and significantly up-regulated the expression of Bax in MCF-7 cells.
Regulation (regulated) of Gene_expression (expression) of Bax in MCF-7
7) Confidence 0.42 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 0.99 Pain Relevance 0.13
Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells.
Regulation (regulation) of Gene_expression (expressions) of Bax associated with prostate cancer and apoptosis
8) Confidence 0.36 Published 2006 Journal Biol. Pharm. Bull. Section Title Doc Link 16880611 Disease Relevance 1.53 Pain Relevance 0.09
Previously, a similar relation between BAX expression and response to chemotherapy and overall survival in ovarian cancer was reported by others [8,35–37].
Regulation (response) of Gene_expression (expression) of BAX associated with ovarian cancer
9) Confidence 0.34 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.52 Pain Relevance 0
The pro-apoptotic Bax protein is one of the major players in the mitochondrion form of apoptosis [26], and mitochondria-mediated cell death induced by resveratrol may involve stimulation of the expression of the bax gene by p53 or other transcription factors [10,14,27,28].
Spec (may) Regulation (involve) of Gene_expression (expression) of bax associated with apoptosis and death
10) Confidence 0.26 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 1.26 Pain Relevance 0.08
We also investigated the efficacy of chemotherapy and Bax expression, but all patients who treated with chemotherapy showed 2+ in Bax expression.
Spec (investigated) Regulation (efficacy) of Gene_expression (expression) of Bax
11) Confidence 0.21 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 0.84 Pain Relevance 0
The change in expression of apoptotic markers (Bcl-2 and Bax proteins) brought about by various chemotherapeutic regimens is being used to identify drug resistance in the tumor cells.
Regulation (change) of Gene_expression (expression) of Bax associated with cancer and apoptosis
12) Confidence 0.20 Published 2004 Journal BMC Cancer Section Abstract Doc Link PMC514705 Disease Relevance 1.23 Pain Relevance 0
Alterations in the levels of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins are known to regulate the commitment to apoptosis [14,15].
Regulation (Alterations) of Gene_expression (levels) of Bax associated with apoptosis
13) Confidence 0.19 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.83 Pain Relevance 0.03
Thus, down-regulation of the Bcl-2/Bax expression ratio could be a predominant mechanism by which DLS induces mitochondria-mediated apoptosis in HepG2 cells.
Regulation (regulation) of Gene_expression (expression) of Bax associated with apoptosis
14) Confidence 0.18 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 1.16 Pain Relevance 0.03
A mitochondrial permeability transition pore activator significantly abolished the anti-apoptotic effect of nicorandil in endothelial cells, indicating that the mechanism of protective effect of nicorandil is involved in the mitochondrial apoptotic pathway although it affects neither Bcl-2 nor Bax protein expression levels.
Neg (neither) Regulation (affects) of Neg (neither) Gene_expression (expression) of Bax protein in endothelial cells associated with apoptosis
15) Confidence 0.13 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16306793 Disease Relevance 0.94 Pain Relevance 0.05
Immunoblot analysis demonstrated that expression of GAAPs did not interfere with Bax expression levels (Figure 5B, right panel).
Neg (not) Regulation (interfere) of Gene_expression (expression) of Bax
16) Confidence 0.10 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1803007 Disease Relevance 0.92 Pain Relevance 0
Compared with parental cells and vector cells, clone 2 and pool 1 cells transfected with pcDNA3.1-FRNK showed a decrease in survivin expression and Bad phosphorylation at Ser136 but did not affect Bax, Bcl-2 or Bad expression or Bad phosphorylation at Ser112 (Fig. 5E).
Neg (not) Regulation (affect) of Gene_expression (expression) of Bax
17) Confidence 0.06 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.63 Pain Relevance 0

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