INT77636

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Context Info
Confidence 0.61
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 1.69
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
DRG 2
nucleus 1
smooth muscle cell 1
Egf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 18 99.98 Very High Very High Very High
cytokine 46 99.08 Very High Very High Very High
metalloproteinase 7 97.72 Very High Very High Very High
chemokine 8 95.84 Very High Very High Very High
Inflammation 20 94.20 High High
Hyperalgesia 28 89.20 High High
sSRI 6 88.88 High High
Serotonin 4 87.52 High High
fluoxetine 8 87.00 High High
ischemia 14 78.32 Quite High
Disease Link Frequency Relevance Heat
Starvation 4 99.12 Very High Very High Very High
Nociception 46 95.36 Very High Very High Very High
INFLAMMATION 22 94.20 High High
Apoptosis 5 92.00 High High
Adhesions 11 89.96 High High
Hyperalgesia 28 89.20 High High
Targeted Disruption 7 80.16 Quite High
Cv Unclassified Under Development 12 78.32 Quite High
Hypoxia 20 77.96 Quite High
Hypertension 8 77.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was determined as phosphorylation (stimulation) of extracellular-regulated kinase 1 and 2 (ERK(1/2)) by transactivation-mediated phosphorylation of the epidermal growth factor (EGF) receptor, followed by conventional EGF receptor signaling (Li et al., Psychopharmacology 194:333-334, 2007).
Phosphorylation (phosphorylation) of epidermal growth factor
1) Confidence 0.61 Published 2009 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 19662385 Disease Relevance 0 Pain Relevance 0.39
This was determined as phosphorylation (stimulation) of extracellular-regulated kinase 1 and 2 (ERK(1/2)) by transactivation-mediated phosphorylation of the epidermal growth factor (EGF) receptor, followed by conventional EGF receptor signaling (Li et al., Psychopharmacology 194:333-334, 2007).
Phosphorylation (phosphorylation) of EGF
2) Confidence 0.61 Published 2009 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 19662385 Disease Relevance 0 Pain Relevance 0.39
EGF-stimulated dephosphorylation of nuclear Grb7 was found to occur at residues phosphorylated by FAK because WT Flag-Grb7 but not the dominant-negative phosphorylation mutant (DM Flag-Grb7; Tsai et al., 2007) was effectively dephosphorylated by EGF treatment (Fig. 4 C).
Phosphorylation (dephosphorylation) of EGF-stimulated
3) Confidence 0.51 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
To identify the phosphatase responsible for EGF-induced dephosphorylation of Grb7 in the nucleus, we examined a direct interaction between the SHP-2 (Src homology region 2–containing phosphatase; Keegan and Cooper, 1996) and Grb7 (Fig.
Phosphorylation (dephosphorylation) of EGF-induced in nucleus
4) Confidence 0.51 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0
Also starvation prior to EGF stimulation did not result in EGF induced Erk1/2 phosphorylation (data not shown).
Phosphorylation (phosphorylation) of EGF associated with starvation
5) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.28 Pain Relevance 0
Nevertheless, we could not detect any EGF induced Erk1/2 phosphorylation.
Phosphorylation (phosphorylation) of EGF
6) Confidence 0.49 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3023724 Disease Relevance 0.22 Pain Relevance 0.36
Decorin can cause the rapid phosphorylation of EGF with the concurrent activation of mitogen-activated kinase protein kinase signal pathway.
Phosphorylation (phosphorylation) of EGF
7) Confidence 0.37 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0
NGF phosphorylated only one whereas epidermal growth factor phosphorylated both isoforms of ShcC in DRG cultures.
Phosphorylation (phosphorylated) of epidermal growth factor in DRG associated with nerve growth factor
8) Confidence 0.27 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9753087 Disease Relevance 0 Pain Relevance 0.39
TGFß1-induced Smad 2/3 phosphorylation and the combination of EGF, LIF and TGFß1 synergistically increased STAT3 phosphorylation over single or double cytokine combinations.
Phosphorylation (phosphorylation) of EGF associated with cytokine
9) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2832687 Disease Relevance 0.28 Pain Relevance 0.23
TGFß1-induced Smad 2/3 phosphorylation and the combination of EGF, LIF and TGFß1 synergistically increased STAT3 phosphorylation over single or double cytokine combinations.
Phosphorylation (phosphorylation) of EGF associated with cytokine
10) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2832687 Disease Relevance 0.28 Pain Relevance 0.23
NGF phosphorylated only one whereas epidermal growth factor phosphorylated both isoforms of ShcC in DRG cultures.
Phosphorylation (phosphorylated) of epidermal growth factor in DRG associated with nerve growth factor
11) Confidence 0.21 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9753087 Disease Relevance 0 Pain Relevance 0.38
Altered integrin signaling, the production of tenacin, epidermal growth factor signaling, tyrosine phosphorylation, and activation of downstream pathways culminate in vascular smooth muscle cell proliferation. [4-6] Evidence is accumulating that matrix molecules provide an environment which decreases the rate of programmed cell death.
Phosphorylation (phosphorylation) of epidermal growth factor in smooth muscle cell associated with apoptosis
12) Confidence 0.16 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.64 Pain Relevance 0.19

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