INT77646

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Context Info
Confidence 0.40
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 7.85
Pain Relevance 9.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) signal transduction (Ngf) extracellular space (Ngf)
extracellular region (Ngf) plasma membrane (Ntrk1) kinase activity (Ntrk1)
Anatomy Link Frequency
neurons 4
brain 2
nerve 2
ganglia 2
sensory neurons 1
Ngf (Mus musculus)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 429 100.00 Very High Very High Very High
neurotrophin 3 6 100.00 Very High Very High Very High
tRK receptor 1 99.92 Very High Very High Very High
Calcitonin gene-related peptide 46 99.72 Very High Very High Very High
nociceptor 143 99.38 Very High Very High Very High
intrathecal 2 98.98 Very High Very High Very High
unmyelinated 16 98.20 Very High Very High Very High
Spinal cord 43 98.10 Very High Very High Very High
Pain 107 97.68 Very High Very High Very High
dorsal root ganglion 81 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 123 99.84 Very High Very High Very High
Nociception 39 98.84 Very High Very High Very High
Frailty 11 98.24 Very High Very High Very High
Targeted Disruption 112 97.82 Very High Very High Very High
Pain 106 97.68 Very High Very High Very High
Ganglion Cysts 236 97.24 Very High Very High Very High
Apoptosis 213 95.64 Very High Very High Very High
Rheumatoid Arthritis 68 95.08 Very High Very High Very High
Bone Cancer 40 91.68 High High
Obesity 2 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutant mice in which TrkA, the high-affinity receptor for nerve growth factor (NGF), has been inactivated lack nociceptive neurones in sensory ganglia and do not respond to noxious stimuli.
NGF Binding (receptor) of TrkA in ganglia associated with nociception and nerve growth factor
1) Confidence 0.40 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9753121 Disease Relevance 0.25 Pain Relevance 0.18
Mutant mice in which TrkA, the high-affinity receptor for nerve growth factor (NGF), has been inactivated lack nociceptive neurones in sensory ganglia and do not respond to noxious stimuli.
nerve growth factor Binding (receptor) of TrkA in ganglia associated with nociception and nerve growth factor
2) Confidence 0.40 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9753121 Disease Relevance 0.25 Pain Relevance 0.18
For example, pro-NGF does not bind TrkA, but causes cell death by binding to p75NTR [7,8].
NGF Neg (not) Binding (bind) of TrkA associated with nerve growth factor and death
3) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.29 Pain Relevance 0.38
The common p75NTR also enhances binding of NGF to TrkA receptors to create high affinity binding sites (Kd~10-11 M), possibly by binding to different surfaces on the NGF dimer [6]. p75NTR can also bind precursor forms of the neurotrophins.
NGF Binding (binding) of TrkA associated with nerve growth factor
4) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.27 Pain Relevance 0.30
Prior studies showed that DRG explants from Runx3-knockout mouse embryos extended short neurites in the presence of NT3, a ligand for TrkC, but not in the presence of NGF, a ligand for TrkA [16].
NGF Binding (ligand) of TrkA in neurites associated with targeted disruption and dorsal root ganglion
5) Confidence 0.36 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.82 Pain Relevance 0.36
NGF binding to TrkA has been shown to directly activate TrkA-expressing nociceptors in vivo and in vitro and that binding of NGF to TrkA directly lowers the threshold for depolarization in these neurons [19,20].
NGF Binding (binding) of TrkA in neurons associated with nerve growth factor and nociceptor
6) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.63 Pain Relevance 1.17
NGF is thought to excite and sensitize sensory neurons by binding to its cognate receptor TrkA which is expressed by a subpopulation of mostly unmyelinated and thinly myelinated sensory neurons [18].
NGF Binding (binding) of TrkA in sensory neurons associated with nerve growth factor and unmyelinated
7) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.81 Pain Relevance 1.21
NGF binds the TrkA receptor, BDNF and NT-4/5 bind the TrkB receptor, and NT-3 primarily binds the TrkC receptor [5].
NGF Binding (binds) of TrkA associated with nerve growth factor
8) Confidence 0.30 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.22 Pain Relevance 0.28
NGF binding to TrkA has been shown to directly activate TrkA-expressing nociceptors in vivo and in vitro and that binding of NGF to TrkA directly lowers the threshold for depolarization in these neurons [19,20].
NGF Binding (binding) of TrkA in neurons associated with nerve growth factor and nociceptor
9) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.59 Pain Relevance 1.25
Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: a structural insight.
NGF Binding (interaction) of TrkA
10) Confidence 0.26 Published 2005 Journal Proteins Section Title Doc Link 15625712 Disease Relevance 0 Pain Relevance 0
Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: a structural insight.
NGF Binding (interaction) of TrkA
11) Confidence 0.26 Published 2005 Journal Proteins Section Title Doc Link 15625712 Disease Relevance 0 Pain Relevance 0
MNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction.
NGF Binding (interaction) of TrkA
12) Confidence 0.26 Published 2005 Journal Proteins Section Abstract Doc Link 15625712 Disease Relevance 0 Pain Relevance 0
MNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction.
NGF Binding (interaction) of TrkA
13) Confidence 0.26 Published 2005 Journal Proteins Section Abstract Doc Link 15625712 Disease Relevance 0 Pain Relevance 0
One population expresses TrkA, the receptor for nerve growth factor (NGF), and calcitonin gene-related peptide (CGRP) and is thus often referred to as the population of peptidergic neurones.
NGF Binding (receptor) of TrkA in nerve associated with nerve growth factor and calcitonin gene-related peptide
14) Confidence 0.13 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.42 Pain Relevance 0.55
One population expresses TrkA, the receptor for nerve growth factor (NGF), and calcitonin gene-related peptide (CGRP) and is thus often referred to as the population of peptidergic neurones.
nerve growth factor Binding (receptor) of TrkA in nerve associated with nerve growth factor and calcitonin gene-related peptide
15) Confidence 0.13 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.42 Pain Relevance 0.55
Neurotrophins exert their biological functions on neurons through two transmembrane receptors: the p75 neurotrophin receptor (p75NTR) and the Trk receptor tyrosine kinases (NGF binds to TrkA, BDNF and NT-4/5 bind to TrkB, and NT-3 preferentially binds to TrkC) [3], [4].
NGF Binding (binds) of TrkA in neurons associated with nerve growth factor
16) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.08 Pain Relevance 0.14
Neurotrophins exert their biological functions on neurons through two transmembrane receptors: the p75 neurotrophin receptor (p75NTR) and the Trk receptor tyrosine kinases (NGF binds to TrkA, BDNF and NT-4/5 bind to TrkB, and NT-3 preferentially binds to TrkC) [3], [4].
NGF Binding (bind) of TrkA in neurons associated with nerve growth factor
17) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.08 Pain Relevance 0.14
Modified from Airaksinen and Saarma (2002). b The neurotrophins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) bind with high affinity to the tyrosine kinase receptors trkA, trkB and trkC, respectively.
nerve growth factor Binding (bind) of trkA in brain associated with neurotrophin 3 and nerve growth factor
18) Confidence 0.11 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.29
Modified from Airaksinen and Saarma (2002). b The neurotrophins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) bind with high affinity to the tyrosine kinase receptors trkA, trkB and trkC, respectively.
NGF Binding (bind) of trkA in brain associated with neurotrophin 3 and nerve growth factor
19) Confidence 0.11 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.29
TRKA is primarily a receptor for NGF, TRKB is a receptor for BDNF and NT-4/5, and TRKC is the specific receptor for NT-3.
NGF Binding (receptor) of TRKA
20) Confidence 0.10 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.42 Pain Relevance 0.22

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