INT7765

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.62
Pain Relevance 5.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
arcuate nucleus 4
neurons 2
nerve 2
brain 2
segmental nerve 2
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
MU agonist 1 100.00 Very High Very High Very High
Clonidine 36 99.98 Very High Very High Very High
Analgesic 2 99.98 Very High Very High Very High
Locus ceruleus 5 99.80 Very High Very High Very High
Somatostatin 10 99.32 Very High Very High Very High
Serotonin 4 98.14 Very High Very High Very High
agonist 15 97.56 Very High Very High Very High
addiction 3 97.56 Very High Very High Very High
5HT 20 97.52 Very High Very High Very High
noradrenaline 6 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 8 99.46 Very High Very High Very High
Sprains And Strains 6 98.40 Very High Very High Very High
Heart Rate Under Development 4 80.00 Quite High
Injury 1 75.76 Quite High
Pain 1 74.32 Quite High
Pressure Volume 2 Under Development 1 68.84 Quite High
Nervous System Injury 1 68.44 Quite High
Hypertension 1 64.80 Quite High
Shock 1 52.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous results from our laboratory indicate that small doses of the alpha-2 adrenergic agonist clonidine increase serotonin (5-HT) neurotransmission by attenuating the release of endogenous norepinephrine (NE), as a result of the activation of alpha-2 adrenergic autoreceptors on NE neurons, and that high doses decrease 5-HT neurotransmission by activating directly alpha-2 adrenergic heteroreceptors on 5-HT terminals.
Positive_regulation (result) of Positive_regulation (activation) of alpha-2 in neurons associated with agonist, serotonin and clonidine
1) Confidence 0.45 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7912278 Disease Relevance 0.05 Pain Relevance 0.48
Activation of alpha-2 adrenergic receptors significantly increased basal gastric tone and reduced the amplitude of phasic contractions.
Positive_regulation (increased) of Positive_regulation (Activation) of alpha-2
2) Confidence 0.36 Published 1991 Journal Acta Physiol. Scand. Section Abstract Doc Link 1683093 Disease Relevance 0.42 Pain Relevance 0.48
These data suggest that the combination of neuropathic surgery and sympathectomy results in an upregulation of active alpha-2 adrenergic receptors on the undamaged sensory axons that provide the remaining sensory innervation to a neuropathic area partially denervated by segmental nerve lesions.
Positive_regulation (results) of Positive_regulation (upregulation) of alpha-2 in segmental nerve associated with neuropathic pain
3) Confidence 0.33 Published 1999 Journal Pain Section Abstract Doc Link 10342420 Disease Relevance 0.81 Pain Relevance 0.52
These findings suggest that clonidine stimulates growth hormone secretion by activation of alpha 2 adrenergic heteroreceptors present on 5-HT nerve terminals which, in turn, enhance 5-HT activity via stimulation of postsynaptic 5-HT1C receptors to promote growth hormone releasing factor.
Positive_regulation (stimulates) of Positive_regulation (activation) of alpha 2 in nerve associated with clonidine
4) Confidence 0.11 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1356149 Disease Relevance 0.34 Pain Relevance 1.12
While this pattern of results is consistent with a presynaptic site of action for alpha-2 involvement in modulating overall activity during a play bout, the same cannot be concluded about any putative explanatory mechanism for alpha-2 involvement in play behavior
Positive_regulation (mechanism) of Positive_regulation (involvement) of alpha-2
5) Confidence 0.11 Published 2000 Journal Dev Psychobiol Section Abstract Doc Link 10937658 Disease Relevance 0 Pain Relevance 0.33
While this pattern of results is consistent with a presynaptic site of action for alpha-2 involvement in modulating overall activity during a play bout, the same cannot be concluded about any putative explanatory mechanism for alpha-2 involvement in play behavior
Positive_regulation (site) of Positive_regulation (involvement) of alpha-2
6) Confidence 0.11 Published 2000 Journal Dev Psychobiol Section Abstract Doc Link 10937658 Disease Relevance 0 Pain Relevance 0.36
An anaesthesia period of 10 minutes induced (1) a fatty acid modification of brain membranes and (2) a significant sensibilization to ouabain for the alpha 2 and alpha 3 isoforms of digitalis receptors (alpha 2, IC50; 8.2 +/- 0.5 x 10(-7) mol/l vs 4.5 +/- 0.2 x 10(-7) mol/l; alpha 3, IC50; 6.0 +/- 0.3 x 10(-8) mol/l vs 2.5 +/- 0.1 x 10(-8).
Positive_regulation (induced) of Positive_regulation (sensibilization) of alpha 2 in brain
7) Confidence 0.07 Published 1997 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 9029486 Disease Relevance 0 Pain Relevance 0.13
These data suggest that the analgesic potentiation of alpha 2 and opioid agonists is not mediated via LC alpha 2 receptors.
Neg (not) Positive_regulation (mediated) of Positive_regulation (potentiation) of alpha 2 associated with mu agonist, locus ceruleus and analgesic
8) Confidence 0.06 Published 1995 Journal Br J Anaesth Section Abstract Doc Link 7880711 Disease Relevance 0 Pain Relevance 1.44
In conclusion, these data suggest that alpha 2 activation of GH secretion requires intact serotonergic terminals in the arcuate nucleus and most likely involves GRH rather than SRIF, release.
Positive_regulation (requires) of Positive_regulation (activation) of alpha 2 in arcuate nucleus associated with somatostatin
9) Confidence 0.02 Published 1990 Journal Endocrinology Section Abstract Doc Link 1688789 Disease Relevance 0 Pain Relevance 0.48
In conclusion, these data suggest that alpha 2 activation of GH secretion requires intact serotonergic terminals in the arcuate nucleus and most likely involves GRH rather than SRIF, release.
Positive_regulation (involves) of Positive_regulation (activation) of alpha 2 in arcuate nucleus associated with somatostatin
10) Confidence 0.02 Published 1990 Journal Endocrinology Section Abstract Doc Link 1688789 Disease Relevance 0 Pain Relevance 0.48

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