INT77651

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.48
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
Caco-2 2
A549 2
respiratory 2
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 36 100.00 Very High Very High Very High
Arthritis 11 98.56 Very High Very High Very High
Inflammation 89 97.94 Very High Very High Very High
Pain 5 94.96 High High
cytokine 51 93.36 High High
cINOD 5 92.04 High High
Paracetamol 5 91.60 High High
aspirin 1 87.24 High High
rheumatoid arthritis 25 84.96 Quite High
peptic ulcer disease 1 79.36 Quite High
Disease Link Frequency Relevance Heat
Arthritis 11 98.56 Very High Very High Very High
INFLAMMATION 98 97.94 Very High Very High Very High
Stomach Cancer 3 97.56 Very High Very High Very High
Ovarian Cancer 8 96.84 Very High Very High Very High
Pain 4 94.96 High High
Purpura 6 94.80 High High
Pressure And Volume Under Development 4 94.60 High High
Disease 16 93.76 High High
Skin Diseases 4 93.32 High High
Apoptosis 2 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This notion is supported by the observation that CXCL8 mRNA expression is decreased after treatment of antigen-induced arthritis [41].
Negative_regulation (decreased) of Transcription (expression) of CXCL8 associated with arthritis
1) Confidence 0.43 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0.96 Pain Relevance 0.56
We also measured IL-8 mRNA levels in experiments performed with A549 cells, as shown in Figure 6A and B.
Negative_regulation (measured) of Transcription (levels) of IL-8 in A549
2) Confidence 0.43 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
In addition, rebamipide suppressed H. pylori-induced IL-8 gene expression at the transcriptional level as revealed by northern blotting analysis and luciferase activity in cells that were transfected with a luciferase expression vector linked with a 5'-flanking region of the IL-8 gene (bp -133 to +44).
Negative_regulation (suppressed) of Transcription (expression) of IL-8
3) Confidence 0.38 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753246 Disease Relevance 0.79 Pain Relevance 0.14
Coincubation with prednisolone resulted in a significant reduction of IL-8 levels.


Negative_regulation (reduction) of Transcription (levels) of IL-8
4) Confidence 0.33 Published 2008 Journal J Inflamm (Lond) Section Abstract Doc Link PMC2507710 Disease Relevance 0.54 Pain Relevance 0.21
This suggests that after 2 h of co-incubation TTSS1 is not involved in IL-8 mRNA production by the Caco-2 cells, while TTSS2 is involved in the inhibition of the IL-8 transcription.
Negative_regulation (inhibition) of Transcription (transcription) of IL-8 in Caco-2
5) Confidence 0.12 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.28 Pain Relevance 0
In the present study, we have demonstrated that KBG treatment significantly suppressed the protein and mRNA levels of MIF, IL-6, IL-8, and TNF-?
Negative_regulation (suppressed) of Transcription (levels) of IL-8
6) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3021874 Disease Relevance 0.56 Pain Relevance 0.14
It is proposed that the major mechanism by these anti-inflammatory agents is a shared pathway dependent on the suppression of NF-kappaB activity, which may subsequently decrease transcription of growth factors, chemokines and proteases such as COX-2, VEGF, IL-8/CXCL8, MCP-1/CCL-2, MIP1alpha/CCL-3, tPA and uPA, which are shown to be elevated in ovarian carcinoma, and which play diverse roles such as inducing angiogenesis, invasion, autocrine growth loops and resistance to apoptosis.
Negative_regulation (decrease) of Transcription (transcription) of CXCL8 associated with chemokine, inflammation, ovarian cancer and apoptosis
7) Confidence 0.04 Published 2004 Journal Neoplasma Section Abstract Doc Link 15254653 Disease Relevance 0.99 Pain Relevance 0.71
Parthenolide had no inhibitory effect on IL-6 mRNA levels in LPS-stimulated macrophages, but did attenuate IL-12 p40 and p35 mRNA expression [14] as well as the chemokine IL-8 in cultured human respiratory epithelium [15].
Negative_regulation (attenuate) of Transcription (expression) of IL-8 in respiratory associated with chemokine
8) Confidence 0.01 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0.35 Pain Relevance 0.39

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