INT77652

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 99
Total Number 99
Disease Relevance 67.57
Pain Relevance 30.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
neutrophils 10
epithelial cells 6
macrophage 4
blood 4
joints 4
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1830 100.00 Very High Very High Very High
cytokine 916 100.00 Very High Very High Very High
rheumatoid arthritis 547 100.00 Very High Very High Very High
chemokine 416 100.00 Very High Very High Very High
substance P 53 100.00 Very High Very High Very High
dexamethasone 49 99.98 Very High Very High Very High
agonist 48 99.98 Very High Very High Very High
Etanercept 35 99.98 Very High Very High Very High
Morphine 18 99.98 Very High Very High Very High
fibrosis 33 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1948 100.00 Very High Very High Very High
Rheumatoid Arthritis 566 100.00 Very High Very High Very High
Obesity 194 100.00 Very High Very High Very High
Fibrosis 44 99.96 Very High Very High Very High
Cancer 557 99.92 Very High Very High Very High
Pressure And Volume Under Development 93 99.92 Very High Very High Very High
Pancreatitis 125 99.90 Very High Very High Very High
Apoptosis 337 99.86 Very High Very High Very High
Skin Cancer 54 99.84 Very High Very High Very High
Adenocarcinoma 401 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, magnesium sulfate differentially suppresses endotoxin-stimulated IL-8 production in amniotic and decidual cells in vitro.
Negative_regulation (suppresses) of Gene_expression (production) of IL-8
1) Confidence 0.59 Published 2006 Journal J. Reprod. Immunol. Section Abstract Doc Link 16384605 Disease Relevance 0.18 Pain Relevance 0.09
Magnesium sulfate dose dependently inhibited the endotoxin-stimulated IL-8 production in both decidual and amniotic cells.
Negative_regulation (inhibited) of Gene_expression (production) of IL-8
2) Confidence 0.59 Published 2006 Journal J. Reprod. Immunol. Section Abstract Doc Link 16384605 Disease Relevance 0.21 Pain Relevance 0.11
Pretreatment of MAPK inhibitors (PD98059 and SB203580) markedly blocked Ca(2+)-induced IL-8 production from cells, and anti-inflammatory drugs, such as dexamethasone and cyclosporin A, partially inhibited the activation of ERK1/2.
Negative_regulation (blocked) of Gene_expression (production) of IL-8 associated with inflammation, cinod and dexamethasone
3) Confidence 0.56 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.17 Pain Relevance 0.22
The inhibition of IL-8 expression was dependent on the concentration of capsaicin and duration of treatment.
Negative_regulation (inhibition) of Gene_expression (expression) of IL-8 associated with qutenza
4) Confidence 0.54 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.65 Pain Relevance 0.40
Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.
Negative_regulation (inhibition) of Gene_expression (expression) of IL-8 associated with qutenza and skin cancer
5) Confidence 0.54 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.65 Pain Relevance 0.39
Downregulation of constitutive and induced NF-kappaB activation in malignant melanoma cells leads to inhibition of IL-8 production and in vitro cell proliferation.
Negative_regulation (inhibition) of Gene_expression (production) of IL-8 associated with skin cancer
6) Confidence 0.54 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.73 Pain Relevance 0.37
Further, downregulation of IL-8 expression in capsaicin-treated melanoma cells resulted in inhibition of in vitro cell proliferation.
Negative_regulation (downregulation) of Gene_expression (expression) of IL-8 associated with qutenza and skin cancer
7) Confidence 0.54 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.71 Pain Relevance 0.42
Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta-induced NF-kappaB, but not AP-1, leading to inhibition of IL-8 expression.
Negative_regulation (inhibition) of Gene_expression (expression) of IL-8 associated with qutenza and skin cancer
8) Confidence 0.54 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.72 Pain Relevance 0.43
Rebamipide inhibited the production of IL-8 in several gastric cancer cell lines infected with H. pylori.
Negative_regulation (inhibited) of Gene_expression (production) of IL-8 associated with stomach cancer
9) Confidence 0.51 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753246 Disease Relevance 0.81 Pain Relevance 0.14
Molecular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastric cancer cell lines.
Negative_regulation (suppression) of Gene_expression (production) of interleukin-8 associated with gastritis and stomach cancer
10) Confidence 0.51 Published 1998 Journal Dig. Dis. Sci. Section Title Doc Link 9753246 Disease Relevance 0.88 Pain Relevance 0.12
Treatment of NHAs with morphine suppressed IL-8 and macrophage-inflammatory protein-1beta gene expression, whereas expression of their receptor genes, CCR3 and CCR5, was simultaneously enhanced.
Negative_regulation (suppressed) of Gene_expression (expression) of IL-8 in macrophage associated with inflammation and morphine
11) Confidence 0.47 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12244149 Disease Relevance 1.14 Pain Relevance 1.29
U87 cells treated with morphine showed significant down-regulation of IL-8 gene expression, whereas expression of the IL-8 receptor CXCR2 was reciprocally up-regulated as detected by RT-PCR.
Negative_regulation (down-regulation) of Gene_expression (expression) of IL-8 associated with morphine
12) Confidence 0.47 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12244149 Disease Relevance 0.82 Pain Relevance 1.17
However, previous studies did demonstrate decreased IL-8 synthesis by HNECs coincubated with LPS and erythromycin even at a concentration of 10-6 M [5].
Negative_regulation (decreased) of Gene_expression (synthesis) of IL-8
13) Confidence 0.45 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2507710 Disease Relevance 0.26 Pain Relevance 0.17
We observed that ciprofloxacin significantly decreased IL-8 synthesis by HNECs.
Negative_regulation (decreased) of Gene_expression (synthesis) of IL-8
14) Confidence 0.45 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2507710 Disease Relevance 0.46 Pain Relevance 0.13
In addition, previous studies demonstrated decreased IL-8 synthesis by HNECs coincubated with LPS and erythromycin at a concentration of 10-6 M [5]
Negative_regulation (decreased) of Gene_expression (synthesis) of IL-8
15) Confidence 0.45 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2507710 Disease Relevance 0.23 Pain Relevance 0.03
Furthermore, neutralization of CXCL8-attenuated crystal-induced arthritis in an animal model [49] and RA patients treated with a high dose of methylprednisolone displayed a significant decrease in CXCL8 expression in ST biopsies together with an excellent clinical response [50].
Negative_regulation (decrease) of Gene_expression (expression) of CXCL8 associated with rheumatoid arthritis and arthritis
16) Confidence 0.43 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0.73 Pain Relevance 0.40
Furthermore, treatment with corticosteroids results in decreased expression of CXCL8 in ST and CXCL8 levels in synovial fluid, decreased migration of neutrophils into the joint, and diminished arthritis activity [29,30,51].
Negative_regulation (decreased) of Gene_expression (expression) of CXCL8 in joint associated with corticosteroid and arthritis
17) Confidence 0.43 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0.94 Pain Relevance 0.56
In RA patients, decreased CXCL8 production has been observed after treatment with methotrexate [61].
Negative_regulation (decreased) of Gene_expression (production) of CXCL8 associated with rheumatoid arthritis and methotrexate
18) Confidence 0.43 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0.93 Pain Relevance 0.56
The expression of IL-8 and the receptor of ELR+CXC chemokine CXCR2 in cancer have been evaluated in numerous studies.
Negative_regulation (receptor) of Gene_expression (expression) of IL-8 associated with chemokine and cancer
19) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.37 Pain Relevance 0.22
In human gut epithelial cells, NHE inhibition using a variety of agents, including amiloride, 5-(N-methyl-N-isobutyl)amiloride, 5-(N-ethyl-N-isopropyl)- amiloride, harmaline, clonidine, and cimetidine, suppressed interleukin-8 (IL-8) production.
Negative_regulation (suppressed) of Gene_expression (production) of interleukin-8 in epithelial cells associated with clonidine
20) Confidence 0.39 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12065299 Disease Relevance 0.91 Pain Relevance 0.35

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