INT77654

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.41
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90aa1) intracellular (Hsp90aa1) protein complex (Hsp90aa1)
cytoplasm (Hsp90aa1) cytosol (Hsp90aa1) protein folding (Hsp90aa1)
Anatomy Link Frequency
urinary bladder 4
uterus 2
skeletal muscle 2
Hsp90aa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
interstitial cystitis 2 94.48 High High
Catecholamine 1 89.80 High High
spastic colon 1 83.80 Quite High
tolerance 22 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 73 100.00 Very High Very High Very High
Shock 12 100.00 Very High Very High Very High
Wound Healing 1 95.68 Very High Very High Very High
Interstitial Cystitis 2 94.48 High High
Diabetes Mellitus 28 93.92 High High
Endometriosis (extended) 2 92.40 High High
Overactive Bladder 2 91.52 High High
Hypoxia 1 87.64 High High
Injury 6 87.12 High High
Functional Bowel Disorder 1 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogenic regulation of HSP90 kD synthesis in rat urinary bladder.
Regulation (regulation) of Gene_expression (synthesis) of HSP90 in urinary bladder
1) Confidence 0.62 Published 2001 Journal Urol. Res. Section Title Doc Link 11762796 Disease Relevance 0.26 Pain Relevance 0.05
HSP90 kD synthesis in the rat urinary bladder is under estrogenic regulation.
Regulation (regulation) of Gene_expression (synthesis) of HSP90 in urinary bladder
2) Confidence 0.45 Published 2001 Journal Urol. Res. Section Abstract Doc Link 11762796 Disease Relevance 0.34 Pain Relevance 0.09
We investigated the influence of water-immersion stress or TRH administration on the expression of 60-kDa, 72-kDa, and 90-kDa heat-shock proteins (HSP60, HSP72, and HSP90, respectively) in rat small intestinal mucosa by Western blot and immunohistochemical analyses.
Spec (investigated) Regulation (influence) of Gene_expression (expression) of HSP90 associated with stress and shock
3) Confidence 0.35 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.75 Pain Relevance 0.13
Recent studies have demonstrated that in the ventromedial hypothalamus (VMH) and uterus, the HSP90 expression was regulated by E2 [33, 42].
Regulation (regulated) of Gene_expression (expression) of HSP90 in uterus
4) Confidence 0.25 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.78 Pain Relevance 0
In the present study, interestingly the expression of the cytoplasmic HSP72 and HSP90 in skeletal muscle was not affected by the exercise-diet intervention in either of the study groups.
Neg (not) Regulation (affected) of Gene_expression (expression) of HSP90 in skeletal muscle
5) Confidence 0.15 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.28 Pain Relevance 0

General Comments

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