INT77655

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Context Info
Confidence 0.38
First Reported 1998
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.70
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspa1b) molecular_function (Hspa1b) cellular_component (Hspa1b)
cytoplasm (Hspa1b)
Anatomy Link Frequency
skeletal muscle 4
heart 2
Hspa1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 66 97.48 Very High Very High Very High
ischemia 4 94.76 High High
Catecholamine 1 89.80 High High
spastic colon 1 83.80 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 63 100.00 Very High Very High Very High
Shock 31 100.00 Very High Very High Very High
Fever 14 99.68 Very High Very High Very High
Paralysis 2 98.64 Very High Very High Very High
Impaired Glucose Tolerance 66 98.16 Very High Very High Very High
Cancer 78 96.80 Very High Very High Very High
Cv Unclassified Under Development 4 94.76 High High
Diabetes Mellitus 84 93.92 High High
Hyperglycemia 3 83.84 Quite High
Functional Bowel Disorder 1 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the influence of water-immersion stress or TRH administration on the expression of 60-kDa, 72-kDa, and 90-kDa heat-shock proteins (HSP60, HSP72, and HSP90, respectively) in rat small intestinal mucosa by Western blot and immunohistochemical analyses.
Spec (investigated) Regulation (influence) of Gene_expression (expression) of HSP72 associated with stress and shock
1) Confidence 0.38 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.75 Pain Relevance 0.13
In agreement with our results, a recent study showed that 14 weeks of training decreased protein carbonyl content and induced HSP60 expression without affecting HSP72 expression in the heart of doxorubicin treated mice [63].
Neg (without) Regulation (affecting) of Gene_expression (expression) of HSP72 in heart
2) Confidence 0.34 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.23 Pain Relevance 0.07
In the present study, interestingly the expression of the cytoplasmic HSP72 and HSP90 in skeletal muscle was not affected by the exercise-diet intervention in either of the study groups.
Neg (not) Regulation (affected) of Gene_expression (expression) of HSP72 in skeletal muscle
3) Confidence 0.34 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.28 Pain Relevance 0
In the present study, however, we neither observed any differences in the HSP72 expression nor 4-HNE protein adduct levels in the skeletal muscles of the subjects with impaired glucose tolerance.
Regulation (differences) of Gene_expression (levels) of HSP72 in skeletal muscles associated with tolerance and impaired glucose tolerance
4) Confidence 0.25 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 0.55 Pain Relevance 0.05
The reason why the combination of both stress factors (cytostatic drug and hyperthermia) had a smaller effect on the level of HSP72 expression remains unclear, but a temporary paralysis of cell function including protein synthesis with gradual recovery could be discussed.
Regulation (effect) of Gene_expression (expression) of HSP72 associated with stress, fever and paralysis
5) Confidence 0.17 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.94 Pain Relevance 0.03
The administration of vinblastine in normothermic perfusions resulted in peak values of HSP72 synthesis after 30 minutes (factor 2.5), which dropped to the base line of the untreated tumor not later than 5 hours after 60-minute perfusion, maybe as a consequence of mdr1-mediated drug efflux of vinblastine.
Spec (maybe) Regulation (values) of Gene_expression (synthesis) of HSP72 associated with cancer
6) Confidence 0.15 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.95 Pain Relevance 0.05

General Comments

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