INT77656

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 37
Disease Relevance 24.27
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90aa1) intracellular (Hsp90aa1) protein complex (Hsp90aa1)
cytoplasm (Hsp90aa1) cytosol (Hsp90aa1) protein folding (Hsp90aa1)
Anatomy Link Frequency
urinary bladder 2
uterus 1
RVLM 1
skeletal muscle 1
cleavage 1
Hsp90aa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 9 97.86 Very High Very High Very High
aspirin 7 96.84 Very High Very High Very High
interstitial cystitis 3 89.84 High High
cINOD 3 88.52 High High
fibrosis 2 87.92 High High
Catecholamine 1 87.20 High High
ischemia 33 85.92 High High
Inflammation 55 85.24 High High
cytokine 4 83.20 Quite High
alcohol 60 82.32 Quite High
Disease Link Frequency Relevance Heat
Shock 150 100.00 Very High Very High Very High
Endotoxemia 5 99.96 Very High Very High Very High
Stress 1297 99.66 Very High Very High Very High
Injury 155 99.34 Very High Very High Very High
Apoptosis 18 97.12 Very High Very High Very High
Wound Healing 25 95.68 Very High Very High Very High
Peptic Ulcer 25 94.16 High High
Diabetes Mellitus 56 93.92 High High
Heart Rate Under Development 1 92.20 High High
Pressure Volume 2 Under Development 1 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ELISA showed significant differences in HSP90 kD synthesis as early as 6 h compared to controls (P< 0.05).
Gene_expression (synthesis) of HSP90
1) Confidence 0.78 Published 2001 Journal Urol. Res. Section Abstract Doc Link 11762796 Disease Relevance 0.29 Pain Relevance 0.07
Estrogenic regulation of HSP90 kD synthesis in rat urinary bladder.
Gene_expression (synthesis) of HSP90 in urinary bladder
2) Confidence 0.78 Published 2001 Journal Urol. Res. Section Title Doc Link 11762796 Disease Relevance 0.26 Pain Relevance 0.05
HSP90 kD synthesis in the rat urinary bladder is under estrogenic regulation.
Gene_expression (synthesis) of HSP90 in urinary bladder
3) Confidence 0.78 Published 2001 Journal Urol. Res. Section Abstract Doc Link 11762796 Disease Relevance 0.33 Pain Relevance 0.09
These data could suggest that the gender difference in the development of stress-induced gastric mucosal injury in rats might be related to the expression levels of HSP90 and HSP60 in the gastric mucosa.
Gene_expression (expression) of HSP90 associated with stress and injury
4) Confidence 0.72 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.71 Pain Relevance 0
On the other hand, the present study demonstrated that the expression of HSP90 and HSP60 showed a gender difference.
Gene_expression (expression) of HSP90
5) Confidence 0.72 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.94 Pain Relevance 0
Female rats were more resistant to the development of gastric ulceration by the WI-stress due to a higher expression level of gastric HSP90 and HSP60 compared to the male rats.
Gene_expression (expression) of HSP90 associated with stress
6) Confidence 0.72 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.85 Pain Relevance 0
As shown in Fig. 1e–g, there was a significant main effect of the sex difference in the HSP expression [HSP60, df = 1, F = 30.7, p<0.0001; HSP90, df = 1, F = 34.6, p<0.0001] such that the HSP60 and HSP90 expression after WI-stress in the female rats was significantly higher than that in the male rats, and there was also a main effect of time after the WI-stress [HSP60, df = 3, F = 12.8, p<0.0001] such that the male rats after the WI-stress expressed less HSP60 than that in the female rats.
Gene_expression (expression) of HSP90 associated with stress
7) Confidence 0.72 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.87 Pain Relevance 0
In addition, an ovariectomy reduced the expression of HSP60, HSP70, and HSP90 and significantly increased the severity of the WI-stress-induced gastric mucosal lesions in the female rats.
Gene_expression (expression) of HSP90 associated with stress
8) Confidence 0.72 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.78 Pain Relevance 0
In the female rat gastric mucosa, the basal expression levels of HSP60 (t test, p = 0.0011) and HSP90 (t test, p = 0.016) were significantly higher compared to those in the males (Fig. 1d).
Gene_expression (expression) of HSP90
9) Confidence 0.72 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.81 Pain Relevance 0
Furthermore, the treatment of male rats with estrogen significantly increased the expression of HSP60, HSP70, and HSP90 and reduced the severity of the WI-stress-induced gastric mucosal lesions.
Gene_expression (expression) of HSP90 associated with stress
10) Confidence 0.72 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.82 Pain Relevance 0
Especially, the expression level of HSP90 in the female gastric mucosa increased from earlier time points and showed a higher level at all time points compared to in the male gastric mucosa (Bonferroni correction, 3 h WI-stress, p = 0.03; 6 h WI-stress, p = 0.023, 12 h WI-stress, p = 0.002).
Gene_expression (expression) of HSP90 associated with stress
11) Confidence 0.72 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.86 Pain Relevance 0
RT-PCR and Western blotting techniques were used to analyze mRNA and protein expression of HSP72 and HSP90 and cleavage of caspase 3 protein.
Spec (analyze) Gene_expression (expression) of HSP90 in cleavage
12) Confidence 0.65 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10859212 Disease Relevance 0.75 Pain Relevance 0.28
Moreover, heat shock strongly induced renal HSP72 and HSP32/HO-1, and to a lesser extent HSP90, expression.
Gene_expression (expression) of HSP90 associated with shock
13) Confidence 0.64 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 0.95 Pain Relevance 0.18
Hyperthermic preconditioning induces strong and long lasting HO-1/HSP32, HSP72, and HSP90 expression in rat kidneys.
Gene_expression (expression) of HSP90
14) Confidence 0.64 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 0.59 Pain Relevance 0.03
We investigated the influence of water-immersion stress or TRH administration on the expression of 60-kDa, 72-kDa, and 90-kDa heat-shock proteins (HSP60, HSP72, and HSP90, respectively) in rat small intestinal mucosa by Western blot and immunohistochemical analyses.
Gene_expression (expression) of HSP90 associated with stress and shock
15) Confidence 0.60 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753281 Disease Relevance 0.74 Pain Relevance 0.12
There was also an E2-treatment × time interaction [HSP90, df = 1, F = 7.87, p = 0.011] in which the intra-peritoneal injection of E2 significantly induced the expression of HSP90 in the gastric mucosa compared to that in the untreated male control rats.
Gene_expression (expression) of HSP90
16) Confidence 0.55 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.33 Pain Relevance 0
An estrogen-treatment significantly induced the expression of HSP60, HSP70 and HSP90 in the gastric mucosa.
Gene_expression (expression) of HSP90
17) Confidence 0.55 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2901766 Disease Relevance 0.54 Pain Relevance 0
These observations suggested that the gender difference observed in the development of the stress-induced gastric mucosal injury in rats might be partly explained by the differences in the gastric mucosal levels of HSP90, HSP70, and HSP60 induced by estrogen.
Gene_expression (levels) of HSP90 associated with stress and injury
18) Confidence 0.55 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.75 Pain Relevance 0
As shown in Fig. 2c, there was a significant main effect of the E2-treatment [HSP90, df = 1, F = 17.44, p = 0.0005], and there was also a main effect of time after the E2-treatment [HSP90, df = 1, F = 7.85, p = 0.011] such that the control group expressed less HSP90 than the E2-administered group.
Gene_expression (expressed) of HSP90
19) Confidence 0.55 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.43 Pain Relevance 0
Inversely, when ovariectomized female rats were treated with estrogen, the severity of the stress-induced gastric mucosal lesions was reduced with the recovered levels of HSP60, HSP70, and HSP90 in the gastric mucosa.
Gene_expression (levels) of HSP90 associated with stress
20) Confidence 0.55 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.73 Pain Relevance 0

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