INT77662

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Context Info
Confidence 0.60
First Reported 1998
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.93
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CDK5R1) cytosol (CDK5R1) plasma membrane (CDK5R1)
nucleus (CDK5R1) embryo development (CDK5R1) kinase activity (CDK5R1)
Anatomy Link Frequency
neuronal 1
CDK5R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Versed 7 94.44 High High
narcan 4 91.76 High High
Central nervous system 33 87.96 High High
cerebral cortex 3 80.96 Quite High
Analgesic 2 75.92 Quite High
Neuritis 3 51.92 Quite High
opioid receptor 1 49.04 Quite Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 33 97.80 Very High Very High Very High
Aging 3 96.76 Very High Very High Very High
Syndrome 9 96.60 Very High Very High Very High
Apoptosis 3 96.28 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 6 95.32 Very High Very High Very High
Intellectual Impairment 15 94.80 High High
Nervous System Malformation 27 88.44 High High
Congenital Anomalies 3 84.32 Quite High
Motor Neuron Diseases 3 77.08 Quite High
Disease 12 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While thiopental sodium and propofol suppressed P 100 amplitude, they had no effect on N 20, P 25, P 45 latencies.
Neg (no) Regulation (effect) of P 25
1) Confidence 0.60 Published 1998 Journal Masui Section Abstract Doc Link 9753959 Disease Relevance 0 Pain Relevance 0.46
More recently the CDK5/p35 complex has also been reported to regulate several activities such as exocytosis, gene transcription, tissue regeneration, senescence, apoptosis and hormone regulation also in extra-neuronal cells [20].
Regulation (regulate) of p35 in neuronal associated with aging and apoptosis
2) Confidence 0.43 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 1.28 Pain Relevance 0.08
CDK5R1 mRNA is a target of nELAV RNA-binding proteins
Regulation (target) of CDK5R1 mRNA
3) Confidence 0.26 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.05 Pain Relevance 0
It has recently been demonstrated in mouse that p35 protein level is a rate-limiting factor for the up-regulation of Cdk5 activity [59].
Regulation (regulation) of p35
4) Confidence 0.26 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.60 Pain Relevance 0.08

General Comments

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