INT77665

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Context Info
Confidence 0.02
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.54

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mitochondrion (Nme4) structural constituent of ribosome (Nme4) oxidoreductase activity (Nme4)
ribosome (Nme4) intracellular (Nme4) translation (Nme4)
Nme4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fortral 3 100.00 Very High Very High Very High
methadone 2 100.00 Very High Very High Very High
Morphine 2 100.00 Very High Very High Very High
Enkephalin 2 99.64 Very High Very High Very High
opioid receptor 2 75.00 Quite High
Opioid 2 62.88 Quite High
Analgesic 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding of morphine, methadone, pentazocine, [D-Ala2, NMePhe4, Gly-ol]enkephalin (DAMGO) and Tyr-Pro-NMePhe-D-Pro-NH2 (PL017) was exothermic (deltaH degrees' = -3.53 to -9.95 kcal/mol) and occurred with an increase in entropy (-TdeltaS degrees' = -2.48 to -7.92 kcal/mol).
NMePhe4 Binding (binding) of associated with fortral, enkephalin, methadone and morphine
1) Confidence 0.02 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9754924 Disease Relevance 0 Pain Relevance 0.54

General Comments

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