INT77670

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 21.68
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACLY) mitochondrion (ACLY) small molecule metabolic process (ACLY)
nucleolus (ACLY) plasma membrane (ACLY) nucleus (ACLY)
Anatomy Link Frequency
tibia 1
anterior 1
leg muscles 1
platelet 1
neural 1
ACLY (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 114 98.64 Very High Very High Very High
Osteoarthritis 53 97.92 Very High Very High Very High
rheumatoid arthritis 129 97.28 Very High Very High Very High
spinal inflammation 56 96.72 Very High Very High Very High
fibrosis 6 96.52 Very High Very High Very High
local anesthetic 4 96.52 Very High Very High Very High
anesthesia 11 94.64 High High
Infliximab 112 93.92 High High
imagery 126 87.28 High High
alcohol 6 86.08 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 13 99.96 Very High Very High Very High
Coronary Heart Disease 22 99.88 Very High Very High Very High
Infection 94 99.64 Very High Very High Very High
Hepatitis C Virus Infection 30 99.44 Very High Very High Very High
Syndrome 275 99.36 Very High Very High Very High
Acute Coronary Syndrome 14 99.32 Very High Very High Very High
Demyelinating Disease 146 98.64 Very High Very High Very High
Thrombosis 171 98.44 Very High Very High Very High
Knee Osteoarthritis 4 98.32 Very High Very High Very High
Deafness 54 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fifty-two patients who had an extraarticular reconstruction for anterior cruciate ligament (ACL) insufficiency were interviewed at an average of 11.4 years after their reconstruction.
Positive_regulation (reconstruction) of ACL in anterior
1) Confidence 0.49 Published 2000 Journal J South Orthop Assoc Section Abstract Doc Link 12132807 Disease Relevance 0.14 Pain Relevance 0
Because the synovium around the ACL was dissected, the blood flow was temporarily reduced so there is a possibility that loosening of the ACL may increase during the process of remodeling.
Positive_regulation (increase) of ACL in blood
2) Confidence 0.46 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2678102 Disease Relevance 0.47 Pain Relevance 0.03
Returning to high level athletic activity is an ultimate goal for patient who undergoes ACL reconstruction.
Positive_regulation (undergoes) of ACL
3) Confidence 0.44 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2744659 Disease Relevance 0.08 Pain Relevance 0
Daniel concluded that there is a low probability that patients with an acute traumatic haemarthrosis that is found stable on instrumented examination will develop laxity over a five year period and that many of the ACL injured patients who did not undergo ACL reconstruction surgery continued to participate in sports activities.
Neg (not) Positive_regulation (undergo) of ACL
4) Confidence 0.44 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2430704 Disease Relevance 0.07 Pain Relevance 0
In the former case, the fracture occurred 6 months after an iliotibial band augmentation of a patellar tendon graft ACL reconstruction, whereas the latter case followed 20 months after the removal of a lateral augmentation device used in an ACL reinsertion.
Positive_regulation (augmentation) of ACL in lateral
5) Confidence 0.43 Published 2009 Journal J Orthop Traumatol Section Body Doc Link PMC2837813 Disease Relevance 0.17 Pain Relevance 0.05
Movement of the knee from a flexed to an extended position, either passively or through contraction of the leg muscles, produces an increase in ACL strain values.
Positive_regulation (increase) of ACL in leg muscles associated with sprains and strains
6) Confidence 0.41 Published 1998 Journal J Biomech Section Abstract Doc Link 9755036 Disease Relevance 0.65 Pain Relevance 0.09
The ultimate aim of an ACL reconstruction is to restore the function of the intact ACL.
Positive_regulation (restore) of ACL
7) Confidence 0.40 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1635005 Disease Relevance 0 Pain Relevance 0
The aim of this study was to determine if there is a direct reflex response after an isolated mechanical stimulation of the ACL in humans.
Positive_regulation (stimulation) of ACL in ACL
8) Confidence 0.40 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16135551 Disease Relevance 0.18 Pain Relevance 0.07
Direct mechanical stimulation of the ACL evokes considerably smaller SLRs and MLRs than anterior tibia translation during standing.
Positive_regulation (stimulation) of ACL in tibia
9) Confidence 0.40 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16135551 Disease Relevance 0.20 Pain Relevance 0.18
This study concluded that the LARS could be considered as a viable option for ACL reconstruction in terms of patient satisfaction.
Positive_regulation (option) of ACL
10) Confidence 0.34 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC3016369 Disease Relevance 0.23 Pain Relevance 0
The implant was considered sufficiently flexible to be effective with a maximal tensile strength of approximately 2100 Newtons (N), which significantly exceeds that of the average young adults’ natural ACL (about 1730 N) (24).
Positive_regulation (exceeds) of ACL
11) Confidence 0.28 Published 2008 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2322926 Disease Relevance 0 Pain Relevance 0
Despite the complex nature of the inter-dependent factors at play during the recovery and rehabilitative period following an ACL reconstruction, much of the literature today suggests that tissue engineering techniques will lead to a new generation of ACL replacements, capable of regenerating a mechanically robust and natural ACL.


Positive_regulation (generation) of ACL
12) Confidence 0.28 Published 2008 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2322926 Disease Relevance 0 Pain Relevance 0
Six patients had previously had an unsuccessful ACL reconstruction.
Positive_regulation (unsuccessful) of ACL
13) Confidence 0.28 Published 2008 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2322926 Disease Relevance 0.29 Pain Relevance 0.05
We observed a significant increase in aCL antibody titres, starting from 30 weeks for IgM antibodies and at 78 weeks for IgG antibodies.
Positive_regulation (increase) of aCL
14) Confidence 0.15 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.56 Pain Relevance 0.16
There have been reports on recurrent episodes of cerebral ischaemia in patients with livedo reticularis (Sneddon's syndrome) with aPLs suggesting the presence of APS.131,132 A more rapid progression and more severe clinical manifestations are seen in patients with increased aCL levels.
Positive_regulation (increased) of aCL associated with syndrome, cv general 4 under development, anti-phospholipid antibody syndrome and livedo reticularis
15) Confidence 0.14 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.59 Pain Relevance 0.23
Another woman, age 55, with a six-year history of Sjögren's syndrome who presented with IgG and IgM aCL elevations and developed a sudden onset of sensori-neural hearing loss associated with vertigo was also described.201 Another report202 described 30 patients, 11 of whom suffered from sudden deafness and 19 of whom presented with progressive sensori-neural hearing loss and had been matched to 20 healthy controls.
Positive_regulation (elevations) of aCL in neural associated with deafness, vertigo, syndrome and sudden hearing loss
16) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.41 Pain Relevance 0.09
Patients with MS-like illnesses and aPLs130 were so similar to other MS patients that they should not be excluded from clinical trials.188 A study in 1998183 found a large, significant proportion of aCL-positive patients in non-classic MS (with similar patterns including progressive myelopathy, spinocerebellar syndrome, or neuromyelitis optica).
Positive_regulation (proportion) of aCL associated with spinal cord diseases, neuromyelitis optica, multiple sclerosis and syndrome
17) Confidence 0.10 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.26 Pain Relevance 0.63
The investigation of the link between aPLs and dementia173 indicated that 6% of patients had significantly elevated aCL IgG levels (> 20 GPL).
Positive_regulation (elevated) of aCL
18) Confidence 0.09 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.83 Pain Relevance 0.08
Cyanotic congenital heart disease with elevated aCL has also been reported (with thrombotic episodes and/or thrombocytopenia).29 At the same time, post-surgery complications in APS have also been reported: a hypercoagulable condition has been detected in 10% of patients undergoing cardiovascular surgical procedures leading to a higher incidence of early graft thrombosis (27% vs. 1.6%).30 A constellation of risk factors identified the highest-risk patient: female, young, non-smoker, and more likely to have upper extremity involvement than patients who were aPL-negative.31 Other authors32 have found that 26% of patients were aPL-positive and were 1.8 times more likely to have undergone previous lower-extremity vascular surgical procedures and 5.6 times more likely to have suffered occlusion during previous reconstructions.


Spec (found) Positive_regulation (elevated) of aCL in upper associated with anti-phospholipid antibody syndrome, thrombocytopenia, thrombosis related under development and coronary heart disease
19) Confidence 0.09 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.77 Pain Relevance 0.05
Several explanations exist as to why increased aCL may contribute to increased thrombotic risk, including platelet damage, interference with antithrombin III activity, and inhibition of prekallikrein or protein C activation by thrombomodulin [19,20].
Positive_regulation (increased) of aCL in platelet
20) Confidence 0.08 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2987921 Disease Relevance 0.91 Pain Relevance 0

General Comments

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