INT77674

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 11.92
Pain Relevance 6.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 6
Saa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 500 100.00 Very High Very High Very High
cytokine 54 100.00 Very High Very High Very High
spinal inflammation 246 99.48 Very High Very High Very High
Inflammatory response 63 95.12 Very High Very High Very High
Tendonitis 12 93.44 High High
Arthritis 19 92.56 High High
corticosteroid 6 89.12 High High
cINOD 24 86.40 High High
chemokine 6 74.24 Quite High
rheumatoid arthritis 24 57.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 377 100.00 Very High Very High Very High
Amyloidosis 36 100.00 Very High Very High Very High
Stress 337 99.48 Very High Very High Very High
Low Back Pain 264 99.48 Very High Very High Very High
Disease 248 98.48 Very High Very High Very High
Endotoxemia 5 95.20 Very High Very High Very High
Uveitis 18 93.92 High High
Tendinopathy 12 93.44 High High
Arthritis 19 92.56 High High
Targeted Disruption 57 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A time course study with 1% w/w cholesterol (HC diet) showed that plasma SAA levels started to increase after 2 weeks and that plasma SAA levels continued to increase over time (Figure 4c).
Positive_regulation (increase) of Gene_expression (levels) of SAA in plasma associated with inflammation
1) Confidence 0.36 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.42 Pain Relevance 0.50
0.75% w/w), plasma SAA levels increased markedly.
Positive_regulation (increased) of Gene_expression (levels) of SAA in plasma
2) Confidence 0.36 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.36 Pain Relevance 0.52
A time course study with 1% w/w cholesterol (HC diet) showed that plasma SAA levels started to increase after 2 weeks and that plasma SAA levels continued to increase over time (Figure 4c).
Positive_regulation (increase) of Gene_expression (levels) of SAA in plasma associated with inflammation
3) Confidence 0.36 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.43 Pain Relevance 0.50
In particular, significant elevations of both SAA levels and BASDAI scores were noted in those with normal ESR and CRP levels, and SAA levels and BASDAI scores showed a trend of positive correlation with one another in these patients.
Positive_regulation (elevations) of Gene_expression (levels) of SAA
4) Confidence 0.33 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.12 Pain Relevance 0.61
, which are important inducers of SAA production35,36 Our patient with amyloidosis was on glucocorticoids, and thus, there is a possibility that the suppression of inflammatory cytokines with glucocorticoids might also suppress the synthesis of SAA.
Positive_regulation (inducers) of Gene_expression (production35,36) of SAA associated with amyloidosis, inflammation and cytokine
5) Confidence 0.33 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.38 Pain Relevance 0.62
Twenty of 38 patients (52.6%) had increased SAA levels, but the remaining 18 patients (47.4%) had normal SAA levels.
Positive_regulation (increased) of Gene_expression (levels) of SAA
6) Confidence 0.33 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 0.98 Pain Relevance 0.78
, which are important inducers of SAA production35,36 Our patient with amyloidosis was on glucocorticoids, and thus, there is a possibility that the suppression of inflammatory cytokines with glucocorticoids might also suppress the synthesis of SAA.
Positive_regulation (inducers) of Gene_expression (synthesis) of SAA associated with amyloidosis, inflammation and cytokine
7) Confidence 0.33 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.47 Pain Relevance 0.67
Patients with AS had significantly higher mean SAA levels than controls (p < 0.05) (Fig. 1).


Positive_regulation (mean) of Gene_expression (levels) of SAA associated with spinal inflammation
8) Confidence 0.33 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.60 Pain Relevance 1.23
The mean BASDAI score of those with normal SAA levels was 4.4 ± 1.5, and the mean score of those with increased SAA levels was 5.6 ± 1.3.
Positive_regulation (increased) of Gene_expression (levels) of SAA
9) Confidence 0.33 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 0.76 Pain Relevance 0.60
Thus, preservation of Eh Cys/CySS by SAA supplementation may be involved in decreased IL-1?
Positive_regulation (preservation) of Gene_expression (supplementation) of SAA
10) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2657829 Disease Relevance 0.40 Pain Relevance 0.05
Levels of SAA that increase > 100% 24 h after angioplasty may serve as a marker of restenosis.


Positive_regulation (increase) of Gene_expression (Levels) of SAA
11) Confidence 0.28 Published 1998 Journal Clin Cardiol Section Body Doc Link 9755382 Disease Relevance 0 Pain Relevance 0

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