INT77675

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 40
Total Number 44
Disease Relevance 43.37
Pain Relevance 18.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 4
liver 3
macrophages 1
hepatocytes 1
monocytes 1
Saa (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 91 99.96 Very High Very High Very High
Inflammation 990 99.48 Very High Very High Very High
spinal inflammation 909 99.40 Very High Very High Very High
cytokine 240 99.08 Very High Very High Very High
Tendonitis 44 98.96 Very High Very High Very High
spondylitis 67 98.76 Very High Very High Very High
Arthritis 70 98.52 Very High Very High Very High
Inflammatory stimuli 25 97.76 Very High Very High Very High
corticosteroid 22 95.36 Very High Very High Very High
Pain 45 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 172 100.00 Very High Very High Very High
Rheumatoid Arthritis 91 99.96 Very High Very High Very High
Alzheimer's Dementia 286 99.92 Very High Very High Very High
Pancreatitis 10 99.68 Very High Very High Very High
Stress 350 99.48 Very High Very High Very High
Disease 828 99.42 Very High Very High Very High
Low Back Pain 976 99.40 Very High Very High Very High
Amyloidosis 193 99.28 Very High Very High Very High
INFLAMMATION 926 99.24 Very High Very High Very High
Uveitis 66 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some research concerning the acute phase proteins revealed that both SAA and CRP are produced in the liver, but serum levels of the former depend on a larger number of pro-inflammatory cytokines than the latter.8,28-30 Consequently, we can guess that there is a possible difference between SAA and CRP in reflecting disease activity, and this phenomenon originated not only from the facilities of synthesis by their own structural properties, but also the types and amounts of cytokines participate in the production.
Gene_expression (produced) of SAA in liver associated with inflammation, disease and cytokine
1) Confidence 0.58 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.66 Pain Relevance 0.75
According to previous studies regarding the clinical markers in RA, SAA is massively produced through the signaling pathways of pro-inflammatory cytokines such as IL-1?
Gene_expression (produced) of SAA associated with inflammation, rheumatoid arthritis and cytokine
2) Confidence 0.51 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.38 Pain Relevance 0.74
We evaluated SAA production in the serum of patients with AS as compared to controls, and investigated the relationship between SAA and previously established disease activity indicators.
Gene_expression (production) of SAA associated with spinal inflammation and disease
3) Confidence 0.51 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.30 Pain Relevance 0.59
0.75% w/w), plasma SAA levels increased markedly.
Gene_expression (levels) of SAA in plasma
4) Confidence 0.48 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.30 Pain Relevance 0.50
A time course study with 1% w/w cholesterol (HC diet) showed that plasma SAA levels started to increase after 2 weeks and that plasma SAA levels continued to increase over time (Figure 4c).
Gene_expression (levels) of SAA in plasma associated with inflammation
5) Confidence 0.48 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.42 Pain Relevance 0.50
A time course study with 1% w/w cholesterol (HC diet) showed that plasma SAA levels started to increase after 2 weeks and that plasma SAA levels continued to increase over time (Figure 4c).
Gene_expression (levels) of SAA in plasma associated with inflammation
6) Confidence 0.48 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.36 Pain Relevance 0.47
Twenty of 38 patients (52.6%) had increased SAA levels, but the remaining 18 patients (47.4%) had normal SAA levels.
Gene_expression (levels) of SAA
7) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 0.98 Pain Relevance 0.75
As a result, we found that SAA levels of patients with AS were significantly higher than in the control patients and showed significant positive correlations with both clinical and laboratory parameters reflecting the inflammatory burden of AS.
Gene_expression (levels) of SAA associated with spinal inflammation and inflammation
8) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.15 Pain Relevance 0.56
However, the presence of peripheral arthritis, Achilles' tendonitis and uveitis were not significantly associated with SAA levels, and differences in medications did not affect SAA levels, either.
Gene_expression (levels) of SAA associated with tendonitis, uveitis and arthritis
9) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.18 Pain Relevance 0.88
We excluded patients who had a medical or surgical illness such as recent infection, trauma and/or a neoplastic disease, in order to remove other confounding factors affecting SAA level.


Gene_expression (level) of SAA associated with cancer, injury and infection
10) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.64 Pain Relevance 0.65
, which are important inducers of SAA production35,36 Our patient with amyloidosis was on glucocorticoids, and thus, there is a possibility that the suppression of inflammatory cytokines with glucocorticoids might also suppress the synthesis of SAA.
Gene_expression (production35,36) of SAA associated with amyloidosis, inflammation and cytokine
11) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.33 Pain Relevance 0.59
The mean BASDAI score of those with normal SAA levels was 4.4 ± 1.5, and the mean score of those with increased SAA levels was 5.6 ± 1.3.
Gene_expression (levels) of SAA
12) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 0.75 Pain Relevance 0.60
The mean BASDAI score of those with normal SAA levels was 4.4 ± 1.5, and the mean score of those with increased SAA levels was 5.6 ± 1.3.
Gene_expression (levels) of SAA
13) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 0.88 Pain Relevance 0.73
In particular, significant elevations of both SAA levels and BASDAI scores were noted in those with normal ESR and CRP levels, and SAA levels and BASDAI scores showed a trend of positive correlation with one another in these patients.
Gene_expression (levels) of SAA
14) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.06 Pain Relevance 0.61
All control subjects had normal SAA levels, and their mean SAA level was 2.73 ± 1.57 mg/L.
Gene_expression (level) of SAA
15) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.61 Pain Relevance 1.26
, and its level is more sensitive than CRP.6,21-23 Other reports on PMR suggested that serum SAA is more predominant than ESR or CRP with regard to sensitivity and specificity, respectively, and its level can reflect the disease activity effectively.8,24,25 But, in AS, SAA has not been studied as extensively as in RA or PMR, and we could find only a few studies investigating the association between SAA and disease activity of AS.21,26,27 One of these studies reported that SAA levels in patients with AS correlated well with BASDAI scores, and that ESR and CRP levels seem to be a good indicator of disease activity.21 Our results were also similar to those previously reported, but we tried to identify the superiority of SAA to ESR or CRP in determining the extent of AS disease activity.
Gene_expression (levels) of SAA associated with spinal inflammation, polymyalgia rheumatica, rheumatoid arthritis and disease
16) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.50 Pain Relevance 0.68
Twenty of 38 patients (52.6%) had increased SAA levels, but the remaining 18 patients (47.4%) had normal SAA levels.
Gene_expression (levels) of SAA
17) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 0.90 Pain Relevance 0.75
Patients with AS had significantly higher mean SAA levels than controls (p < 0.05) (Fig. 1).


Gene_expression (levels) of SAA associated with spinal inflammation
18) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.59 Pain Relevance 1.23
, which are important inducers of SAA production35,36 Our patient with amyloidosis was on glucocorticoids, and thus, there is a possibility that the suppression of inflammatory cytokines with glucocorticoids might also suppress the synthesis of SAA.
Gene_expression (synthesis) of SAA associated with amyloidosis, inflammation and cytokine
19) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.14 Pain Relevance 0.59
In particular, significant elevations of both SAA levels and BASDAI scores were noted in those with normal ESR and CRP levels, and SAA levels and BASDAI scores showed a trend of positive correlation with one another in these patients.
Gene_expression (levels) of SAA
20) Confidence 0.44 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.05 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox